{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:09:47Z","timestamp":1778029787081,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["SUB\/1\/DN\/20\/003\/1164"],"award-info":[{"award-number":["SUB\/1\/DN\/20\/003\/1164"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["B.SUB.25617"],"award-info":[{"award-number":["B.SUB.25617"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Due to the limitations of SRP, new methods are being sought to support non-surgical periodontal therapy. One of them is the use of antiseptics such as low-concentration sodium hypochlorite gel buffered with amino acids (NaOCl\/AA). The aim of the study was to evaluate periodontal parameters and the concentration of metalloproteinase 8 (MMP-8) and interleukin 8 (IL-8) in the gingival crevicular fluid (GCF) after SRP with or without NaOCL\/AA gel. The study included 40 periodontal patients randomized to study and control groups. Before SRP, the study group had a gel introduced into pockets with PD \u2265 5 mm. After treatment in both groups, the pocket depth (PD) decreased, there was a CAL gain, and unnoticeable changes in the gingival recession (GR). In the study group, deep pockets accounted for 25% of the sites examined prior to therapy, whereas after therapy, they decreased to 12%. In the control group, the proportion of deep periodontal pockets (PD \u2265 5 mm) fell from 17.46% to 9.05%. No differences were noted between groups. In the study group, there was a significant reduction in the amount of MMP-8 in GCF from 8.32 ng\/mL to 5.14 ng\/mL after 3 months. No statistically significant difference was observed in the control group. The concentration of IL-8 decreased significantly over time in both groups without differences between them. A single application of the NaOCl\/AA gel in deep periodontal pockets does not affect clinical results and IL-8 levels. However, it had a significant effect on the amount of MMP-8.<\/jats:p>","DOI":"10.3390\/jfb16120470","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:45:07Z","timestamp":1766065507000},"page":"470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sodium Hypochlorite\/Amino Acid Gel in the Non-Surgical Treatment of Periodontitis\u2014Clinical and Molecular Results of Randomized Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-4990","authenticated-orcid":false,"given":"Ewa","family":"Doli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 15, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Goli\u0144ska","sequence":"additional","affiliation":[{"name":"Private Practice, ul. Rybacka 24A\/1, 12-200 Pisz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-0997","authenticated-orcid":false,"given":"Violetta","family":"Dymicka-Piekarska","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-8283","authenticated-orcid":false,"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Medical University of Bialystok, ul. Szpitalna 37, 15-295 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-8907","authenticated-orcid":false,"given":"Magdalena","family":"Sulewska","sequence":"additional","affiliation":[{"name":"Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 15, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-0769","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Pietruska","sequence":"additional","affiliation":[{"name":"Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 15, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jcpe.12944","article-title":"Age-dependent distribution of periodontitis in two countries: Findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012","volume":"45","author":"Billings","year":"2018","journal-title":"J. Clin. 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