{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:45Z","timestamp":1790023365246,"version":"4.0.1"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Hyaluronic acid (HA) is a biologically active glycosaminoglycan with recognized roles in wound healing and inflammation modulation, and its adjunctive use in dental and periodontal therapy has gained interest, particularly in medically compromised patients. This narrative review critically evaluated preclinical and clinical evidence on locally applied HA in periodontal, oral surgical, peri-implant, and oral medicine treatments in patients with systemic conditions. A literature search of PubMed\/MEDLINE, Scopus, and Web of Science (January 2015\u2013December 2025) identified in vivo translational studies, randomized and controlled clinical trials, and selected systematic reviews involving medically compromised populations. Qualitative synthesis focused on biological plausibility, clinical outcomes, and safety. Nine core studies were included, comprising two preclinical in vivo investigations and seven clinical trials. In diabetic models, cross-linked high-molecular-weight HA reduced macrophage infiltration and delayed collagen membrane degradation without impairing angiogenesis. Clinically, adjunctive HA use in patients with type 2 diabetes mellitus was associated with modest but statistically significant short-term improvements in clinical attachment level (CAL) and enhanced early soft tissue healing following tooth extraction. In peri-implantitis therapy and oncology-related oral complications, HA application was linked to reduced inflammatory markers, decreased lesion severity, and improved patient-reported symptoms. No systemic adverse effects were reported. Overall, HA appears to be a locally safe adjunct that may support early healing and inflammation control in medically compromised patients, although its effects are primarily short-term and do not indicate disease-modifying potential.<\/jats:p>","DOI":"10.3390\/jfb17030154","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:44:41Z","timestamp":1773999881000},"page":"154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hyaluronic Acid as an Adjunctive Therapy in Periodontal and Dental Treatment of Medically Compromised Patients: A Narrative Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-1272","authenticated-orcid":false,"given":"Meizi","family":"Eliezer","sequence":"first","affiliation":[{"name":"University Clinic of Periodontology, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Faculty of Dental Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Bulevardul Revolu\u021biei No. 9, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-5404","authenticated-orcid":false,"given":"Ruxandra","family":"Christodorescu","sequence":"additional","affiliation":[{"name":"Department V\u2014Internal Medicine, Research Center\u2014Institute of Cardiovascular Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Timi\u0219oara, Bulevardul Revolu\u021biei No. 12, 300024 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0206-9110","authenticated-orcid":false,"given":"Alla","family":"Belova","sequence":"additional","affiliation":[{"name":"University Clinic of Periodontology, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Faculty of Dental Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Bulevardul Revolu\u021biei No. 9, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darian","family":"Rusu","sequence":"additional","affiliation":[{"name":"University Clinic of Periodontology, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Faculty of Dental Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Bulevardul Revolu\u021biei No. 9, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Milicescu","sequence":"additional","affiliation":[{"name":"Department of Dental Esthetics, Faculty of Dentistry, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 9 \u0218oseaua Olteni\u021bei, Sector 4, 041292 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-9511","authenticated-orcid":false,"given":"Stefan-Ioan","family":"Stratul","sequence":"additional","affiliation":[{"name":"University Clinic of Periodontology, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Faculty of Dental Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Bulevardul Revolu\u021biei No. 9, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","article-title":"Hyaluronan: Its nature, distribution, functions and turnover","volume":"242","author":"Fraser","year":"1997","journal-title":"J. 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