{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:00:04Z","timestamp":1785427204885,"version":"3.56.0"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFC2405904"],"award-info":[{"award-number":["2022YFC2405904"]}]},{"name":"National Clinical Research Center Project of Shanghai Ninth People\u2019s Hospital","award":["NCRCO202305"],"award-info":[{"award-number":["NCRCO202305"]}]},{"award":["NCRCO202305"],"award-info":[{"award-number":["NCRCO202305"]}],"id":[{"id":"https:\/\/ror.org\/010826a91","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Aid Program of Xinjiang Uygur Autonomous Region","award":["2024E02052"],"award-info":[{"award-number":["2024E02052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Titanium implants are widely used in orthopedic and dental fields but often face challenges such as insufficient osseointegration and peri-implant inflammation. While Strontium (Sr) possesses potent bioactive properties, achieving its controlled delivery at the implant-tissue interface remains technically challenging. To address this, we engineered a multidimensional composite coating by constructing a micro\/nano-porous TiO2 substrate via micro-arc oxidation (MAO), followed by polydopamine (PDA)-assisted Sr immobilization. This integrated architecture significantly enhanced surface hydrophilicity and facilitated high-content Sr loading with sustained release kinetics. Biological evaluations demonstrated that the PDA-mediated interface promoted superior initial adhesion and spreading of bone marrow mesenchymal stem cells (BMSCs), synergizing with released Sr2+ to markedly upregulate core osteogenic markers (Runx2, ALP). Crucially, the functionalized surface actively optimized the immune microenvironment by inducing M1-to-M2 macrophage polarization and comprehensively suppressing RANKL-induced osteoclastogenesis via the downregulation of TRAP and DC-STAMP. By integrating these pro-osteogenic, anti-inflammatory, and anti-resorptive capabilities, this tri-functional system effectively rebalances the bone remodeling microenvironment. Consequently, it provides a robust, universally applicable strategy for enhancing the therapeutic efficacy of next-generation orthopedic and dental implants.<\/jats:p>","DOI":"10.3390\/jfb17040181","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:40:31Z","timestamp":1775554831000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteogenic and Anti-Inflammatory Effects of Strontium-Loaded Polydopamine on Micro-Arc Oxidized Titanium Surfaces"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6158-743X","authenticated-orcid":false,"given":"Yiming","family":"Yang","sequence":"first","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Orthodontics, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongpu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Prosthodontics, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Implant Alveolar Surgery, The Stomatological Center of Weifang People\u2019s Hospital, Weifang 261000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Orthodontics, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-6381","authenticated-orcid":false,"given":"Zhenxia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Orthodontics, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of General Dentistry, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai 200011, China"},{"name":"Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Orthodontics, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0921-5093(97)00806-X","article-title":"Titanium alloys for biomedical applications","volume":"243","author":"Niinomi","year":"1998","journal-title":"Mater. 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