{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:22:13Z","timestamp":1790194933061,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0008\/2020 \u2011DOI 10.54499\/LA\/P\/0008\/2020, UIDP\/50006\/2020 \u2011DOI 10.54499\/UIDP\/50006\/2020, UIDB\/50006\/2020 \u2011DOI 10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020 \u2011DOI 10.54499\/LA\/P\/0008\/2020, UIDP\/50006\/2020 \u2011DOI 10.54499\/UIDP\/50006\/2020, UIDB\/50006\/2020 \u2011DOI 10.54499\/UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"award":["LA\/P\/0008\/2020 \u2011DOI 10.54499\/LA\/P\/0008\/2020, UIDP\/50006\/2020 \u2011DOI 10.54499\/UIDP\/50006\/2020, UIDB\/50006\/2020 \u2011DOI 10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020 \u2011DOI 10.54499\/LA\/P\/0008\/2020, UIDP\/50006\/2020 \u2011DOI 10.54499\/UIDP\/50006\/2020, UIDB\/50006\/2020 \u2011DOI 10.54499\/UIDB\/50006\/2020"]}],"id":[{"id":"https:\/\/ror.org\/00snfqn58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["J. Funct. Biomater.","JFB"],"abstract":"<jats:p>Objectives: This study aimed to compare vertical bone gain (VBG) and horizontal bone gain (HBG) after guided bone regeneration using titanium-reinforced dense PTFE (TiR-dPTFE) versus reinforced PTFE mesh (RPM) at 9 and 12 months on three-dimensional tomographic imaging, and to perform histological assessment in selected cases. Materials and Methods: This prospective comparative case series included 14 patients (46 vertical ridge defect sites) treated with guided bone regeneration using either Ti-reinforced dPTFE membranes (TiR-dPTFE; n = 23) or resorbable porcine collagen membranes (RPM; n = 23). All sites received a 60:40 mixture of autogenous bone chips and anorganic bovine bone mineral (ABBM). After 9 months, during implant placement, a protective secondary augmentation using a 70:30 ABBM\/autogenous mixture was performed and covered with a collagen membrane. Vertical and horizontal bone gain (VBG, HBG) were assessed on standardized matched CBCT cross-sections obtained at 9 and 12 months. Core biopsies were harvested at implant placement (9 months) for histological evaluation. Surgical and healing complications were recorded. Results: Both membranes produced significant VBG. TiR-dPTFE achieved greater VBG than RPM at 9 months (p = 0.045) and 12 months (p = 0.012) and remained stable from 9 to 12 months, whereas RPM showed a significant decline over time (MDa \u22120.48 mm; 95% CI \u22120.64 to \u22120.31; p &lt; 0.001). HBG was similar between groups at both time points (p = 0.918 and p = 0.922). No major clinical complications occurred. Histology at 9 months confirmed vital bone formation and graft integration in both groups. Conclusions: Both TiR-dPTFE and RPM are reliable options for vertical ridge augmentation; TiR-dPTFE yielded superior and more stable vertical gains over 12 months, with comparable horizontal outcomes. Clinical Relevance: TiR-dPTFE may offer enhanced vertical augmentation, while both membranes remain suitable for implant site development.<\/jats:p>","DOI":"10.3390\/jfb17050234","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:05:46Z","timestamp":1778162746000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vertical and Horizontal Ridge Augmentation with Titanium-Reinforced Dense PTFE and Reinforced PTFE Mesh: A Prospective Comparative Case Series"],"prefix":"10.3390","volume":"17","author":[{"given":"Liliana Andrea","family":"Silva","sequence":"first","affiliation":[{"name":"Cirurgia Oral, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"Bone Lab, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-2123","authenticated-orcid":false,"given":"Pedro Sousa","family":"Gomes","sequence":"additional","affiliation":[{"name":"Bone Lab, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"LAQV\/REQUIMTE, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-9574","authenticated-orcid":false,"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Bone Lab, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"},{"name":"LAQV\/REQUIMTE, Faculdade de Medicina Dent\u00e1ria, Universidade do Porto, 4200-393 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-1505","authenticated-orcid":false,"given":"Marta","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"IDIBELL Research Institute, 08908 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-2226","authenticated-orcid":false,"given":"Octavi","family":"Camps-Font","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"IDIBELL Research Institute, 08908 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"Guided bone regeneration: Materials and biological mechanisms revisited","volume":"125","author":"Elgali","year":"2017","journal-title":"Eur. 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