{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:41:11Z","timestamp":1789544471447,"version":"build-2803163510"},"reference-count":118,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Chronic wounds remain a major clinical and economic burden due to persistent inflammation, impaired perfusion, microbial biofilms, and dysregulated immune responses that collectively stall epithelialization. Polymicrobial bacterial\u2013fungal biofilms, including Candida species, further delay healing by sustaining inflammation and promoting treatment-resistant infection. Recent advances have accelerated the development of bioengineered skin substitutes, collagen matrices, and placental-derived grafts that modulate macrophage polarization, reactive oxygen species signaling, and extracellular matrix remodeling to restore tissue architecture and promote neovascularization. Their effectiveness, however, depends on integration within structured care pathways that emphasize debridement, moisture balance, and infection control. Artificial intelligence, three-dimensional bioprinting, flexible microelectronic sensors for real-time wound monitoring, and bioactive compounds derived from traditional Chinese medicine, are expanding the therapeutic landscape. Together, these innovations support a shift toward predictive, personalized, and regenerative wound-care strategies. This review aims to provide a mechanistic and clinically contextualized overview of advanced grafting biomaterials, highlighting current applications, limitations, and future directions in chronic wound care.<\/jats:p>","DOI":"10.3390\/jfb17050239","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:10:42Z","timestamp":1778505042000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advanced Grafting Biomaterials and Technologies in Chronic Wound Care: Mechanisms, Clinical Outcomes, and Therapeutic Integration"],"prefix":"10.3390","volume":"17","author":[{"given":"Albert D.","family":"Luong","sequence":"first","affiliation":[{"name":"Innovative Wound Care (IWC), Fresno, CA 93710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moorthy","family":"Maruthapandi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel"},{"name":"Bar-Ilan Institute for Nanotechnology and Advanced Material, Bar-Ilan University, Ramat-Gan 52900, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-1223","authenticated-orcid":false,"given":"John H. T.","family":"Luong","sequence":"additional","affiliation":[{"name":"School of Chemistry, University College Cork, T12 YN60 Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e3914749222","DOI":"10.33448\/rsd-v14i7.49222","article-title":"Global burden of diabetic foot ulcers: A systematic review on prevalence, mortality, and clinical-economic impact","volume":"14","author":"Santos","year":"2025","journal-title":"Res. Soc. Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bjd.20692","article-title":"A narrative review of the epidemiology and economics of chronic wounds","volume":"187","author":"Graves","year":"2022","journal-title":"Br. J. 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