{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:06:15Z","timestamp":1784091975848,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Porous silicate scaffolds represent a promising class of grafting materials for hard tissue engineering due to their superior bioactivity, adjustable degradation rates, and ability to stimulate both osteogenesis and angiogenesis. In this work, scaffolds based on an akermanite-targeted (Ca2MgSi2O7) starting composition, including copper-doped variants, were synthesized using sol\u2013gel and combustion routes, followed by 3D printing to achieve porous architectures with controlled pore size and interconnectivity. The powders were characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermal analysis to evaluate their morphology, composition, and crystalline phases. The scaffolds were further assessed in terms of bioactivity by immersion in simulated body fluid (SBF), antibacterial activity, and in vitro cellular response. The results confirmed that copper doping enhanced antibacterial properties, while maintaining favorable biological behavior. Comparative analysis revealed differences between the two synthesis methods, with sol\u2013gel providing more homogeneous structures and combustion leading to highly porous morphologies. These findings highlight copper-doped silicate scaffolds as promising candidates for bone tissue regeneration, combining architectural integrity with biological functionality.<\/jats:p>","DOI":"10.3390\/jfb17070335","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:17:51Z","timestamp":1783606671000},"page":"335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copper-Doped Silicate Porous Architectures for Hard Tissue Engineering"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0873-9408","authenticated-orcid":false,"given":"Cristina","family":"Cristea","sequence":"first","affiliation":[{"name":"Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eliza","family":"Puscasu","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"},{"name":"National Center of Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-540X","authenticated-orcid":false,"given":"Gabriela-Olimpia","family":"Isopencu","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-1094","authenticated-orcid":false,"given":"Ovidiu-Cristian","family":"Oprea","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-5380","authenticated-orcid":false,"given":"Vasile-Adrian","family":"Surdu","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Faculty of Materials Science and Engineering, Transilvania University of Brasov, 29 Eroilor Blvd., RO-500036 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-6002","authenticated-orcid":false,"given":"Mihaela","family":"Bacalum","sequence":"additional","affiliation":[{"name":"Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Moisa","sequence":"additional","affiliation":[{"name":"Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin-Ion","family":"Jinga","sequence":"additional","affiliation":[{"name":"Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-8459","authenticated-orcid":false,"given":"Cristina","family":"Busuioc","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"},{"name":"National Center of Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, RO-060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.biomaterials.2016.01.012","article-title":"Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review","volume":"83","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kim, Y.-H., Vijayavenkataraman, S., and Cidonio, G. 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