{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:41:34Z","timestamp":1786527694701,"version":"build-2736575974"},"reference-count":182,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Funct. Biomater.","JFB"],"abstract":"<jats:p>Reconstructive surgery still faces various challenges when dealing with the reconstruction of complex skin defects, regardless of their origin (e.g., trauma, burns). Split-thickness autologous skin grafts remain the gold standard; however, this technique comes with several limitations, including donor site morbidity, infection, and scarring. Since extensive research on conventional techniques has not provided sufficient long-term results, there has been a shift toward dermal substitutes made from regenerative biomaterials that can aid wound management and support tissue restoration. This structured review will introduce the challenges posed by complex skin defects, the limitations of autologous skin grafts and conventional reconstruction techniques, and the emerging field of dermal substitutes and biomimetic scaffolds. Moreover, the native dermis is presented as a blueprint for biomimetic scaffold design, along with key principles to consider when engineering a dermal scaffold, from architecture and porosity to angiogenic potential. A critical examination of the main classes of available dermal substitutes and their clinical performance is conducted, highlighting their limitations and the translational gaps in current evidence. Although the current pool of biomaterials still faces challenges in accurately mimicking the properties and architecture of natural skin, future perspectives offer promising alternatives that could overcome these limitations.<\/jats:p>","DOI":"10.3390\/jfb17080397","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:11:36Z","timestamp":1786525896000},"page":"397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Dermal Substitutes for Skin Reconstruction: Advances in Scaffold Design, Biological Integration, and Clinical Performance"],"prefix":"10.3390","volume":"17","author":[{"given":"Bogdan Mircea M\u0103ciuceanu","family":"Z\u0103rnescu","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 8, Eroii Sanitari, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia Ioana","family":"Lungu","sequence":"additional","affiliation":[{"name":"Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor St., 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-504X","authenticated-orcid":false,"given":"Adelina-Gabriela","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, 050657 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Scafa Udri\u0219te","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 8, Eroii Sanitari, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-9190","authenticated-orcid":false,"given":"Constantin Cosmin","family":"Baciu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 8, Eroii Sanitari, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2, Central Military Emergency University Hospital Dr. Carol Davila, 010825 Bucharest, Romania"},{"name":"Department of Medico-Surgical and Prophylactic Disciplines, \u2018Titu Maiorescu\u2019 University, 031593 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Radu","family":"R\u0103dulescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 8, Eroii Sanitari, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-094X","authenticated-orcid":false,"given":"Alexandru Mihai","family":"Grumezescu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, 050657 Bucharest, Romania"},{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Gh. Polizu St. 1\u20137, 060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"V\u00e2lcea","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d, 8, Eroii Sanitari, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Grosu-Bularda, A., Hodea, F.V., Cretu, A., Lita, F.F., Bordeanu-Diaconescu, E.M., Vancea, C.V., Lascar, I., and Popescu, S.A. (2024). Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects. J. Clin. 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