{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:29:48Z","timestamp":1786768188424,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160355"],"award-info":[{"award-number":["82160355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["82160355"],"award-info":[{"award-number":["82160355"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"crossref","award":["20212ACB214002"],"award-info":[{"award-number":["20212ACB214002"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"crossref","award":["20242BAB25359"],"award-info":[{"award-number":["20242BAB25359"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ganjiang Innovation Talent Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Funct. Biomater.","JFB"],"abstract":"<jats:p>In this study, bacitracin\u2014a small-molecule antibacterial agent\u2014was incorporated into the network structure of a type I collagen\/bacterial cellulose (Col\/BC) composite via in situ recombination and impregnation adsorption, leveraging the well-established drug-loading capacity and sustained-release characteristics of type I collagen. The obtained BA@Col\/BC (BA@CBC) functional dressing features a well-defined nanoporous architecture, high porosity (83.9 \u00b1 1.8%), rapid water absorption kinetics, substantial water absorption capacity (48.7 \u00b1 2.4 g\/g), and satisfactory moisture permeability (2984 \u00b1 56 g\u00b7m2\u00b7day). Critically, the introduction of type I collagen not only effectively delays the release of bacitracin, but also significantly improves the cytocompatibility of the bacterial cellulose-based dressing. BA@CBC exhibits powerful antibacterial activities against S. aureus and MRSA, and can promote the proliferation of NIH3T3 and HUVEC, demonstrating excellent cytocompatibility. In vivo studies in a murine infected-wound model revealed that BA@CBC significantly accelerates wound closure compared to controls; histological evaluation further showed the most organized re-epithelialization, robust granulation tissue formation, and de novo hair follicle regeneration in the BA@CBC group. Fluorescence immunohistochemical analysis confirmed markedly reduced expression of pro-inflammatory cytokines IL-1\u03b2 and TNF-\u03b1 in BA@CBC-treated wounds, indicating effective suppression of excessive inflammation and consequent improvement of the wound microenvironment. Collectively, BA@CBC integrates favorable physicochemical properties, sustained antibacterial functionality, and superior cytocompatibility\u2014positioning it as a promising candidate for clinical management of infected wounds.<\/jats:p>","DOI":"10.3390\/jfb17080400","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:31:09Z","timestamp":1786613469000},"page":"400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacitracin-Loaded Type I Collagen\/Bacterial Cellulose Dressing for the Repair of Infected Wounds"],"prefix":"10.3390","volume":"17","author":[{"given":"Chengcheng","family":"Gong","sequence":"first","affiliation":[{"name":"Department of General Medical, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nanchang Key Laboratory for Smart Biomaterials Regulation and Adaptation & School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Huai","sequence":"additional","affiliation":[{"name":"Nanchang Key Laboratory for Smart Biomaterials Regulation and Adaptation & School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Tong","sequence":"additional","affiliation":[{"name":"Nanchang Key Laboratory for Smart Biomaterials Regulation and Adaptation & School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Tang","sequence":"additional","affiliation":[{"name":"Nanchang Key Laboratory for Smart Biomaterials Regulation and Adaptation & School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Drug Safety Evaluation, Jiangxi Testing Center of Medical Device, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-2648","authenticated-orcid":false,"given":"Haiyong","family":"Ao","sequence":"additional","affiliation":[{"name":"Nanchang Key Laboratory for Smart Biomaterials Regulation and Adaptation & School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China"},{"name":"Jiangxi Key Lab of Flexible Electronics & Flexible Electronics Innovation Institute, Jiangxi Science and Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12037","DOI":"10.1002\/bmm2.12037","article-title":"Hydrogel wound dressings for diabetic foot ulcer treatment: Status-quo, challenges, and future perspectives","volume":"1","author":"Ko","year":"2023","journal-title":"BMEMat"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e12021","DOI":"10.1002\/bmm2.12021","article-title":"Responsive hydrogel dressings for intelligent wound management","volume":"1","author":"Wang","year":"2023","journal-title":"BMEMat"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"tkaf049","DOI":"10.1093\/burnst\/tkaf049","article-title":"Research progress of responsive electrospun dressings for precise monitoring and treatment of diabetic wounds","volume":"14","author":"Zhou","year":"2026","journal-title":"Burn. 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