{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:05:58Z","timestamp":1789689958620,"version":"4.0.1"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARDEC Academy, Rimini, Italy"},{"id":[{"id":"https:\/\/ror.org\/01zezwk04","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Funct. Biomater.","JFB"],"abstract":"<jats:p>Background: This study compared four biomaterials after maxillary sinus floor elevation in rabbits, focusing on graft persistence, tissue organization, space maintenance, and Schneiderian membrane response. Methods: Thirteen adult New Zealand White rabbits were enrolled, including 12 males and one female replacement animal; 12 animals provided evaluable specimens, with six assigned to each healing interval. Four elevated sinus compartments per evaluable animal were randomly allocated to Bio-Oss\u00ae, mp3\u00ae, ReproBone\u00ae novo Paste, or Alos Granular. Specimens were collected after 2 or 10 weeks (n = 6 each). Histomorphometry quantified new bone, residual graft, soft tissue, elevated area, mucosal alterations, and IBN-like tissue, defined as areas in which biomaterial and bone could not be reliably separated. A combined graft and IBN percentage was calculated. Results: At 10 weeks, materials differed in residual graft (p = 0.0040) and combined graft and IBN percentage (p = 0.0218); Bio-Oss\u00ae showed higher values than Alos Granular for both outcomes (adjusted p = 0.0024 and 0.0219, respectively). IBN-like tissue was higher in ReproBone\u00ae novo Paste and Alos Granular than in Bio-Oss\u00ae (adjusted p = 0.0219 and 0.0417), whereas only a small proportion occurred in mp3\u00ae. New bone did not differ among materials at either interval. Bio-Oss\u00ae and mp3\u00ae showed predominantly conventional osteoconduction. Alos Granular showed extensive degradation, whereas ReproBone\u00ae novo Paste exhibited irregular graft and IBN regions. In the descriptive mucosal assessment, thinning was observed in all groups, whereas perforations were observed only at Bio-Oss\u00ae-treated sites; no inferential comparisons were performed for these outcomes. Conclusions: The materials differed in graft persistence, tissue architecture, dimensional stability, and mucosal response. Sinus graft evaluation should extend beyond new bone formation to include residual graft, IBN-like tissue, space maintenance, and mucosal compatibility.<\/jats:p>","DOI":"10.3390\/jfb17090437","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Histological and Histomorphometric Analysis of Xenografts and Synthetic Biomaterials in Rabbit Sinus Floor Elevation"],"prefix":"10.3390","volume":"17","author":[{"given":"Hirotomo","family":"Yanagiuchi","sequence":"first","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, Osaka-573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, Osaka-573-1121, Japan"},{"name":"Ardec Academy, 47921 Riccione, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-384X","authenticated-orcid":false,"given":"Erick Ricardo","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto 14040-904, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-5886","authenticated-orcid":false,"given":"Samuel Porfirio","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto 14040-904, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Giovanna","family":"Iezzi","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University G. d\u2019Annunzio of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Takahito","family":"Uwazumi","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, Osaka-573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Shunsuke","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, Osaka-573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sabri, H., Saleh, M.H.A., Nava, P., Scaini, R., Testori, T., and Del Fabbro, M. (2026). Long-term outcomes of lateral sinus floor elevation: A machine-learning analysis, systematic review, and meta-analysis of predictive factors. Periodontol. 2000, Epub ahead of print.","DOI":"10.1111\/prd.70028"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S346","DOI":"10.1111\/clr.14457","article-title":"Patient-Reported Outcome Measures (PROMs) and Clinician-Reported Outcomes (ClinROs) in Sinus Floor Elevation for Implant Rehab in the Edentulous Maxilla: A Systematic Review and COSMIN Analysis","volume":"37","author":"Sabri","year":"2026","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ghodsian, D., D\u2019Jes\u00fas, S., S\u00e1nchez-Labrador, L., Cobo-V\u00e1zquez, C.M., Cort\u00e9s-Bret\u00f3n Brinkmann, J., Mart\u00ednez-Gonz\u00e1lez, J.M., and Meniz-Garc\u00eda, C. (2024). Maxillary Sinus Augmentation with Autogenous Tooth Grafting Material: A Systematic Review. Biomimetics, 9.","DOI":"10.3390\/biomimetics9090518"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1600-0501.2009.01733.x","article-title":"Sinus augmentation analysis revised: The gradient of graft consolidation","volume":"20","author":"Busenlechner","year":"2009","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1600-0501.2010.02069.x","article-title":"Influence of space-filling materials in subantral bone augmentation: Blood clot vs. autogenous bone chips vs. bovine hydroxyapatite","volume":"22","author":"Lambert","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0501.2004.01003.x","article-title":"Grafting of deproteinized bone particles inhibits bone resorption after maxillary sinus floor elevation","volume":"15","author":"Xu","year":"2004","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/clr.12702","article-title":"Histomorphometric outcomes after lateral sinus floor elevation procedure: A systematic review of the literature and meta-analysis","volume":"27","author":"Corbella","year":"2016","journal-title":"Clin. Oral Implant Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bjoms.2019.03.006","article-title":"Evaluation of three-dimensional contraction of the volume of grafts after staged augmentation of the sinus floor","volume":"57","author":"Zhang","year":"2019","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/jcpe.12728","article-title":"Volumetric changes of grafted volumes and the Schneiderian membrane after transcrestal and lateral sinus floor elevation procedures","volume":"44","author":"Temmerman","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1600-0501.2011.02245.x","article-title":"Volumetric changes of the graft after maxillary sinus floor augmentation with Bio-Oss and autogenous bone in different ratios: A radiographic study in minipigs","volume":"23","author":"Jensen","year":"2012","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bjoms.2021.02.009","article-title":"Xenograft materials in maxillary sinus floor elevation surgery: A systematic review with network meta-analyses","volume":"59","author":"Canellas","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40729-023-00502-1","article-title":"The impact of deproteinized bovine bone particle size on histological outcomes in sinus floor elevation: A systematic review and meta-analysis","volume":"9","author":"Li","year":"2023","journal-title":"Int. J. Implant Dent."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bjoms.2022.03.009","article-title":"Comparison of the osteogenic effectiveness of an autogenous demineralised dentin matrix and Bio-Oss\u00ae in bone augmentation: A systematic review and meta-analysis","volume":"60","author":"Li","year":"2022","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jbm.b.31529","article-title":"Physicochemical characterization of biomaterials commonly used in dentistry as bone substitutes\u2014Comparison with human bone","volume":"92","author":"Figueiredo","year":"2010","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_15","first-page":"325","article-title":"Three-dimensional assessment after maxillary sinus grafting with a bovine, a porcine, and a synthetic bone substitute material. A randomized controlled clinical trial","volume":"27","author":"Schmitt","year":"2024","journal-title":"Int. J. Comput. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zamure-Damberga, L., Radzins, O., Salms, G., Zolovs, M., Bokvalde, Z., and Neimane, L. (2024). Long-Term Volumetric Stability of Maxillary Sinus Floor Augmentation Using a Xenograft Bone Substitute and Its Combination with Autologous Bone: A 6+ Year Retrospective Follow-Up Study Using Cone Beam Computed Tomography. Dent. J., 12.","DOI":"10.3390\/dj12050121"},{"key":"ref_17","first-page":"835","article-title":"Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: A histologic long-term report of 20 cases in humans","volume":"14","author":"Piattelli","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.11607\/jomi.6884","article-title":"20-Year Follow-up in Maxillary Sinus Floor Elevation Using Bovine-Derived Bone Mineral: A Case Report with Histologic and Histomorphometric Evaluation","volume":"33","author":"Valentini","year":"2018","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bjoms.2004.10.004","article-title":"Long-term outcome of augmentation of the maxillary sinus using deproteinised bone particles experimental study in rabbits","volume":"43","author":"Xu","year":"2005","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02340.x","article-title":"A 6-month histological analysis on maxillary sinus augmentation with and without use of collagen membranes over the osteotomy window: Randomized clinical trial","volume":"24","author":"Barone","year":"2013","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Correia, F., Pozza, D.H., Gouveia, S., Felino, A.C., and Faria-Almeida, R. (2021). Advantages of Porcine Xenograft over Autograft in Sinus Lift: A Randomised Clinical Trial. Materials, 14.","DOI":"10.3390\/ma14123439"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"104137","DOI":"10.1016\/j.jdent.2022.104137","article-title":"Guided implant surgery and sinus lift in severely resorbed maxillae: A retrospective clinical study with up to 10 years of follow-up","volume":"121","author":"Pistilli","year":"2022","journal-title":"J. Dent."},{"key":"ref_23","first-page":"417","article-title":"On the Use of a Sticky Bone Substitute in the Presence of a Ruptured Sinus Membrane During Sinus Elevation Procedures: An Experimental Rabbit Study","volume":"40","author":"Taniguchi","year":"2025","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0142-9612(00)00312-4","article-title":"Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone","volume":"22","author":"Wenz","year":"2001","journal-title":"Biomaterials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/PPA.S186846","article-title":"Multicenter study of patients\u2019 preferences and concerns regarding the origin of bone grafts utilized in dentistry","volume":"13","author":"Bucchi","year":"2019","journal-title":"Patient Prefer Adherence"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Eliaz, N., and Metoki, N. (2017). Calcium phosphate bioceramics: A review of their history, structure, properties, coating technologies and biomedical applications. Materials, 10.","DOI":"10.3390\/ma10040334"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bozza, B., Pesce, P., Baldi, D., Bagnasco, F., Migliorati, M., and De Angelis, N. (2025). Synthetic Biomaterials for Alveolar Bone Regeneration: A Systematic Review of Clinical Evidence. Materials, 18.","DOI":"10.3390\/ma18235328"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ivanova, N., Ivanov, S., Peev, S., and Dikova, T. (2025). Types of Bone Substitutes and Their Application in Regenerative Medicine: A Systematic Review. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16090341"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40729-025-00636-4","article-title":"New bone formation of biphasic calcium phosphate bone substitute material: A systematic review and network meta-analysis of randomized controlled trials (RCTs)","volume":"11","author":"Somngam","year":"2025","journal-title":"Int. J. Implant Dent."},{"key":"ref_30","first-page":"352","article-title":"Combining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation","volume":"49","author":"Kerckhofs","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.biomaterials.2012.01.015","article-title":"Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers","volume":"33","author":"Chai","year":"2012","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1016\/j.biomaterials.2011.02.047","article-title":"The combined bone forming capacity of human periosteal derived cells and calcium phosphates","volume":"32","author":"Roberts","year":"2011","journal-title":"Biomaterials"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1016\/j.biomaterials.2006.01.039","article-title":"Biodegradable and bioactive porous polymer\/inorganic composite scaffolds for bone tissue engineering","volume":"27","author":"Rezwan","year":"2006","journal-title":"Biomaterials"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ceccarelli, G., Presta, R., Lupi, S.M., Giarratana, N., Bloise, N., Benedetti, L., Cusella De Angelis, M.G., and Rodriguez YBaena, R. (2017). Evaluation of Poly(Lactic-co-glycolic) Acid Alone or in Combination with Hydroxyapatite on Human-Periosteal Cells Bone Differentiation and in Sinus Lift Treatment. Molecules, 22.","DOI":"10.3390\/molecules22122109"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/ten.teb.2012.0443","article-title":"Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration","volume":"19","author":"Jonker","year":"2013","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.3390\/ijms15033640","article-title":"An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering","volume":"15","author":"Gentile","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1708-8208.2007.00067.x","article-title":"Histopathological observations of a polylactic acid-based device intended for guided bone\/tissue regeneration","volume":"10","author":"Polimeni","year":"2008","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Herranz-Diez, C., Crawford, A., Goodchild, R.L., Hatton, P.V., and Miller, C.A. (2022). Stimulation of Metabolic Activity and Cell Differentiation in Osteoblastic and Human Mesenchymal Stem Cells by a Nanohydroxyapatite Paste Bone Graft Substitute. Materials, 15.","DOI":"10.3390\/ma15041570"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kotsu, M., Apaza Alccayhuaman, K.A., Ferri, M., Iezzi, G., Piattelli, A., Fortich Mesa, N., and Botticelli, D. (2022). Osseointegration at Implants Installed in Composite Bone: A Randomized Clinical Trial on Sinus Floor Elevation. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13010022"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40729-020-00236-4","article-title":"New bone ingrowth into \u03b2-TCP\/HA graft activated with argon plasma: A histomorphometric study on sinus lifting in rabbits","volume":"6","author":"Tanaka","year":"2020","journal-title":"Int. J. Implant Dent."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Omori, Y., Botticelli, D., Migani, S., Balan, V.F., Pires Godoy, E., and Xavier, S.P. (2022). Sinus mucosal damage triggered by synthetic or xenogeneic bone substitutes: A histological analysis in rabbits. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13040257"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Nakajima, Y., Botticelli, D., De Rossi, E.F., Ferreira Balan, V., Pires Godoy, E., Ricardo Silva, E., and Xavier, S.P. (2023). Schneiderian membrane collateral damage caused by collagenated and non-collagenated xenografts: A histological study in rabbits. Dent. J., 11.","DOI":"10.3390\/dj11020031"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"177","author":"Hurst","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Maniwa, N., Xavier, S.P., Scombatti de Souza, S.L., Silva, E.R., Botticelli, D., Morinaga, K., and Baba, S. (2024). Sequential Bone Repair in Rabbit Sinus Lifts Using Bio-Oss and Hyaluronic Acid-Polynucleotide Gel (Regenfast). J. Funct. Biomater., 15.","DOI":"10.3390\/jfb15120361"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav. Res. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.11607\/jomi.2667","article-title":"Maxillary sinus grafting with biphasic calcium phosphate ceramics: Clinical and histologic evaluation in man","volume":"28","author":"Mangano","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Morimoto, A., Kobayashi, N., Ferri, M., Iezzi, G., Piattelli, A., Fortich Mesa, N., and Botticelli, D. (2022). Influence on Implant Bone Healing of a Collagen Membrane Placed Subjacent the Sinus Mucosa-A Randomized Clinical Trial on Sinus Floor Elevation. Dent. J., 10.","DOI":"10.3390\/dj10060105"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/j.biomaterials.2008.04.021","article-title":"Simultaneous in vivo comparison of bone substitutes in a guided bone regeneration model","volume":"29","author":"Busenlechner","year":"2008","journal-title":"Biomaterials"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.21873\/invivo.14195","article-title":"Low-temperature Versus High-temperature Sintering: Regenerative and Osteoimmunological Insights from Bio-Oss\u00ae, Ti-Oss\u00ae in Sinus Lift Surgery","volume":"40","author":"Korzinskas","year":"2026","journal-title":"In Vivo"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1708-8208.2010.00274.x","article-title":"Maxillary sinus augmentation using prehydrated corticocancellous porcine bone: Hystomorphometric evaluation after 6 months","volume":"14","author":"Barone","year":"2012","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00784-017-2139-6","article-title":"Regenerative properties of collagenated porcine bone grafts in human maxilla: Demonstrative study of the kinetics by synchrotron radiation microtomography and light microscopy","volume":"22","author":"Giuliani","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Falacho, R.I., Palma, P.J., Marques, J.A., Figueiredo, M.H., Caramelo, F., Dias, I., Viegas, C., and Guerra, F. (2021). Collagenated Porcine Heterologous Bone Grafts: Histomorphometric Evaluation of Bone Formation Using Different Physical Forms in a Rabbit Cancellous Bone Model. Molecules, 26.","DOI":"10.3390\/molecules26051339"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Otero-Cruz, A.R., Pecci-Lloret, M.P., P\u00e9rez-Guzm\u00e1n, N., El-Akrout, A.E., and Ruiz-Roca, J.A. (2026). Autologous Bone Versus Xenograft and Their Combination in Vertical Ridge Augmentation: An Analysis of Graft Resorption and Implant Survival-A Systematic Review. Dent. J., 14.","DOI":"10.3390\/dj14060321"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40729-021-00346-7","article-title":"Management of Schneiderian membrane perforations during maxillary sinus floor augmentation with lateral approach in relation to subsequent implant survival rates: A systematic review and meta-analysis","volume":"7","year":"2021","journal-title":"Int. J. Implant Dent."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1600-0501.2008.01612.x","article-title":"Prospective observation of 41 perforations of the Schneiderian membrane during sinus floor elevation","volume":"19","author":"Becker","year":"2008","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ye, M., Lin, X., Liu, W., Calatrava, J., Huang, W., and Wang, H.L. (2025). Residual ridge height as a potential risk factor for membrane perforation during lateral-window sinus elevation surgery: A systematic review and meta-analysis. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-06902-6"},{"key":"ref_57","first-page":"449","article-title":"Incidence, diagnosis, and treatment of sinus graft infection after sinus floor elevation: A clinical study","volume":"27","author":"Urban","year":"2012","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/cid.12752","article-title":"The clinical and radiographic outcomes of Schneiderian membrane perforation without repair in sinus elevation surgery","volume":"21","author":"Park","year":"2019","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2500\/105065801779954120","article-title":"Chronic sinusitis complicating sinus lift surgery","volume":"15","author":"Lebowitz","year":"2001","journal-title":"Am. J. Rhinol."},{"key":"ref_60","first-page":"300","article-title":"Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis","volume":"48","author":"Casteleyn","year":"2010","journal-title":"Rhinology"}],"container-title":["Journal of Functional Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4983\/17\/9\/437\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:06:12Z","timestamp":1788257172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4983\/17\/9\/437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jfb17090437"],"URL":"https:\/\/doi.org\/10.3390\/jfb17090437","relation":{},"ISSN":["2079-4983"],"issn-type":[{"value":"2079-4983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}