{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:43:23Z","timestamp":1790487803053,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>The incorporation of strontium chloride to brushite cement was successful to introduce strontium ions within the lattice of brushite crystals. The effect of strontium ions on brushite cement properties was concentration dependent; such that, the addition of 5% and 10% (w\/w) SrCl2 significantly increased the cement FST and the addition of 10% SrCl2 decreased the cement tensile strength. Further, cement weight loss was shown to be increased by cement modification with SrCl2. The combination of ionic substitution and the degradability of brushite cements would constitute a system for the local delivery of strontium ions in the treatment of osteoporosis.<\/jats:p>","DOI":"10.3390\/jfb2020031","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T10:04:20Z","timestamp":1306836260000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride"],"prefix":"10.3390","volume":"2","author":[{"given":"Mohammad H.","family":"Alkhraisat","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica II, Facultad de Farmacia, UCM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rueda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica II, Facultad de Farmacia, UCM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"L\u00f3pez Cabarcos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica II, Facultad de Farmacia, UCM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1136\/bmj.39050.597350.47","article-title":"Osteoporosis and its management","volume":"333","author":"Poole","year":"2006","journal-title":"BMJ"},{"key":"ref_3","first-page":"59","article-title":"The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man","volume":"13","author":"Shorr","year":"1952","journal-title":"Bull. 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