{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:05:45Z","timestamp":1790683545539,"version":"4.1.0"},"reference-count":161,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Among ocular pathologies, glaucoma is the second leading cause of progressive vision loss, expected to affect 80 million people worldwide by 2020. A primary cause of glaucoma appears to be damage to the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm\u2019s canal, regulate and maintain homeostatic responses to intraocular pressure. In glaucoma, filtration of aqueous humor into the Schlemm\u2019s canal is hindered, leading to an increase in intraocular pressure and subsequent damage to the optic nerve, with progressive vision loss. The Schlemm\u2019s canal encompasses a unique endothelium. Recent advances in culturing and manipulating Schlemm\u2019s canal cells have elucidated several aspects of their physiology, including ultrastructure, cell-specific marker expression, and biomechanical properties. This review highlights these advances and discusses implications for engineering a 3D, biomimetic, in vitro model of the Schlemm\u2019s canal endothelium to further advance glaucoma research, including drug testing and gene therapy screening.<\/jats:p>","DOI":"10.3390\/jfb6030963","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T10:17:32Z","timestamp":1442830652000},"page":"963-985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["A Closer Look at Schlemm\u2019s Canal Cell Physiology: Implications for Biomimetics"],"prefix":"10.3390","volume":"6","author":[{"given":"Cula","family":"Dautriche","sequence":"first","affiliation":[{"name":"State University of New York (SUNY) Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzi","family":"Tian","sequence":"additional","affiliation":[{"name":"State University of New York (SUNY) Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Xie","sequence":"additional","affiliation":[{"name":"State University of New York (SUNY) Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-4197","authenticated-orcid":false,"given":"Susan","family":"Sharfstein","sequence":"additional","affiliation":[{"name":"State University of New York (SUNY) Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/0974-9233.148347","article-title":"Update on Schlemm\u2019s canal based procedures","volume":"22","author":"Mansouri","year":"2015","journal-title":"Middle East Afr. 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