{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:14:58Z","timestamp":1775384098096,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis. Patients were evaluated through X-ray images and a millimetric slide over a one year period. The application of CH\/HAP produced an average alveolar bone growth of 5.77 mm (\u00b11.87 mm). At the onset of the study, the dental pocket exhibited a depth level (DPDL) of 8.66 mm and decreased to 3.55 mm one year after the implant. Tooth mobility grade was 2.44 mm at the onset and 0.8 mm at the end of the study with a significant difference of p &lt; 0.001. Moreover, the bone density in the affected areas was similar to the density of the bone adjacent to it. This result was confirmed with the software implant viewer from Anne Solutions Company. In conclusion, the CH\/HAP implant promoted alveolar bone growth in periodontitis patients.<\/jats:p>","DOI":"10.3390\/jfb8030029","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T04:28:26Z","timestamp":1500524906000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis"],"prefix":"10.3390","volume":"8","author":[{"given":"Fabiola","family":"Vaca-Cornejo","sequence":"first","affiliation":[{"name":"Department of Physiology, University Center of Health Sciences ,University of Guadalajara, Guadalajara, Jalisco 44100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery, Fray Antonio Alcalde Hospital, University of Guadalajara, Guadalajara, Jalisco 44100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Center of Health Sciences ,University of Guadalajara, Guadalajara, Jalisco 44100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Sophia Laboratories, Guadalajara 45010, Jalisco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Center of Health Sciences ,University of Guadalajara, Guadalajara, Jalisco 44100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"ref_1","first-page":"283","article-title":"Two patterns of histologic healing in an intrabony defect following treatment with enamel matrix derivative: A human case report","volume":"25","author":"Majzoub","year":"2005","journal-title":"Int. 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