{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:19:43Z","timestamp":1791922783156,"version":"4.3.4"},"reference-count":95,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPESP (S\u00e3o Paulo State Research Support Foundation)","award":["2023\/06853-7"],"award-info":[{"award-number":["2023\/06853-7"]}]},{"name":"FAPESP (S\u00e3o Paulo State Research Support Foundation)","award":["2021\/08618-0"],"award-info":[{"award-number":["2021\/08618-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFMK"],"abstract":"<jats:p>Background\/Objectives: Chronic exposure to stress has been considered a risk factor for hypertension, which is also associated with increased bone resorption. This review aimed to investigate the effect of acute and chronic stress, associated with hypertension, on the skeletal system. Methods: A comprehensive search was conducted across multiple databases, focusing on peer-reviewed articles published in English. We include experimental, clinical, and peer-reviewed studies focused on the relationship between stress, hypertension, and bone resorption. Searches were conducted in MEDLINE via PubMed, Embase and Scopus, with the last search completed on 10 September 2024. Results: The main topics include situations that favor bone loss, such as psychological stress, which can lead to osteoporotic fractures through immunological and endocrine mechanisms. The relationship between psychological stress and loss of bone density, as in osteoporosis, occurs due to the reduction in the number of osteoblasts and loss in the balance between physiological formation\/resorption. Conclusions: Chronic stress significantly affects cardiovascular health and bone resorption. This narrative review study highlights the vulnerability of the skeletal system, along with the cardiovascular system, to prolonged stress, emphasizing the need for multidisciplinary strategies in preventing stress-related conditions. Effective stress management can help reduce the risks of cardiovascular disease and bone resorption, emphasizing their role in comprehensive health care.<\/jats:p>","DOI":"10.3390\/jfmk10010021","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:43:04Z","timestamp":1736145784000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship of Chronic Stress and Hypertension with Bone Resorption"],"prefix":"10.3390","volume":"10","author":[{"given":"Marina Ribeiro","family":"Paulini","sequence":"first","affiliation":[{"name":"Department of Basic and Oral Biology, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (FORP-USP), Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangeles","family":"Aimone","sequence":"additional","affiliation":[{"name":"LABOATEM, Laboratory of Ostearticular Biology and Tissue Engineering, School of Medicine, Rosario S2002, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9804-8421","authenticated-orcid":false,"given":"Sara","family":"Feldman","sequence":"additional","affiliation":[{"name":"LABOATEM, Laboratory of Ostearticular Biology and Tissue Engineering, School of Medicine, Rosario S2002, Argentina"},{"name":"Research Council, National Rosario University (CIUNR-CONICET), Rosario S2002, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1262","authenticated-orcid":false,"given":"Daniela Vieira","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil"},{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ\/USP), Sao Paulo 05508-270, Brazil"},{"name":"Center for the Study of Venoms and Venomous Animals, S\u00e3o Paulo State University (CEVAP\/UNESP), Botucatu 18619-002, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-2218","authenticated-orcid":false,"given":"Rogerio Leone","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ\/USP), Sao Paulo 05508-270, Brazil"},{"name":"Center for the Study of Venoms and Venomous Animals, S\u00e3o Paulo State University (CEVAP\/UNESP), Botucatu 18619-002, Brazil"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo (FOB-USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo Mardegan","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (FORP-USP), Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ferguson, M., Slepian, M., France, C., Svendrovski, A., and Katz, J. 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