{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:32:58Z","timestamp":1787585578856,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFMK"],"abstract":"<jats:p>Background: Transcutaneous Randomized Pulsed Radiofrequency (TCPRF-STP) is a non-invasive therapeutic approach increasingly explored for managing spine-related pain, particularly in cases involving disc herniations and degenerative spine conditions. Objectives: To evaluate the use of transcutaneous PRF-STP in the treatment of spine pathologies and its evolution in short-term follow-up. Methods: This case series examines the outcomes of three patients treated with TCPRF-STP for varying spine pathologies, including lumbar and cervical disc herniations, lumbar stenosis, and radiculopathy. All patients had previously undergone conventional conservative therapies without a satisfactory improvement and were unwilling or unable to undergo invasive procedures. The treatment involved the application of electromagnetic fields through adhesive skin patches at targeted sites. Patients underwent three sessions of TCPRF-STP, with follow-up assessments evaluating pain and MRI. Results: Transcutaneous PRF-STP showed notable reductions in pain (VAS 0 in most cases), improvements in movement, and the restoration of normal daily activities. Follow-up MRI scans demonstrated positive structural changes in the treated discs. Although long-term recurrence occurred in one case, the patient remained active without functional limitations. Conclusions: Transcutaneous PRF-STP offers a promising, minimally invasive alternative for patients seeking to avoid surgery, though further studies with larger cohorts and longer follow-up periods are necessary to establish more robust evidence of its efficacy. This technique could become an important adjunct in managing chronic spinal pain conditions, offering patients an option with minimal risk and hospital demands.<\/jats:p>","DOI":"10.3390\/jfmk10030242","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:23:22Z","timestamp":1750839802000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Transcutaneous Randomized Pulsed Radiofrequency Application for Spine Pain Conditions: A Case Series"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1195-227X","authenticated-orcid":false,"given":"Daniel de Moraes Ferreira","family":"Jorge","sequence":"first","affiliation":[{"name":"Instituto Regenem de Medicina Avan\u00e7ada, S\u00e3o Paulo 04532-002, SP, Brazil"},{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2101-568X","authenticated-orcid":false,"given":"Olav","family":"Rohof","sequence":"additional","affiliation":[{"name":"Pain Clinic, Orbis Medical Centre, 6166 GE Sittard-Geleen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina Brigato Ferreira","family":"Jorge","sequence":"additional","affiliation":[{"name":"Instituto Sensus de Medicina, S\u00e3o Paulo 04532-002, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-6041","authenticated-orcid":false,"given":"Alexandre","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Clinica de Dor, R. S\u00e3o Jo\u00e3o de Brito 610, 4100-455 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezar Augusto","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Orthopedics, ABC Oliveira Medical Clinic, S\u00e3o Paulo 03310-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Sobreiro","sequence":"additional","affiliation":[{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"},{"name":"Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8421-2857","authenticated-orcid":false,"given":"Douglas Freitas","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"},{"name":"Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephany Cares","family":"Huber","sequence":"additional","affiliation":[{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Fabio Santos Duarte","family":"Lana","sequence":"additional","affiliation":[{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"},{"name":"Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil"},{"name":"Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil"},{"name":"Clinical Research, Anna Vit\u00f3ria Lana Institute (IAVL), Indaiatuba 13334-170, SP, Brazil"},{"name":"Medical School, Jaguari\u00fana University Center (UniFAJ), Jaguari\u00fana 13820-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","first-page":"E269","article-title":"Rapid and Delayed Effects of Pulsed Radiofrequency on Neuropathic Pain: Electrophysiological, Molecular, and Behavioral Evidence Supporting Long-Term Depression","volume":"20","author":"Huang","year":"2017","journal-title":"Pain Physician"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/ACO.0000000000000502","article-title":"Pulsed radiofrequency in chronic pain","volume":"30","author":"Vanneste","year":"2017","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3959(95)00102-6","article-title":"The effect of age on A delta- and C-fibre thermal pain perception","volume":"64","author":"Chakour","year":"1996","journal-title":"Pain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11916-998-0011-8","article-title":"Characteristics and mode of action of radiofrequency lesions","volume":"2","author":"Sluijter","year":"1998","journal-title":"Curr. Rev. Pain"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Cui, Y., Shen, H., Chen, Y., Zhang, W., Zhu, J., Duan, Z., Liao, Z., and Weiqiang, L. (2022). Study on the process of intervertebral disc disease by the theory of continuum damage mechanics. Clin. Biomech., 98.","DOI":"10.1016\/j.clinbiomech.2022.105738"},{"key":"ref_6","first-page":"109","article-title":"The effect of pulsed radiofrequency fields applied to the dorsal root ganglion: A preliminary report","volume":"11","author":"Me","year":"1998","journal-title":"Pain Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3171\/2013.5.SPINE12731","article-title":"Changes in pain behavior and glial activation in the spinal dorsal horn after pulsed radiofrequency current administration to the dorsal root ganglion in a rat model of lumbar disc herniation: Laboratory investigation","volume":"19","author":"Cho","year":"2013","journal-title":"J. Neurosurg. Spine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1533-2500.2007.00172.x","article-title":"Intra-articular application of pulsed radiofrequency for arthrogenic pain--report of six cases","volume":"8","author":"Sluijter","year":"2008","journal-title":"Pain Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1533-2500.2009.00317.x","article-title":"Ultrastructural changes in axons following exposure to pulsed radiofrequency fields","volume":"9","author":"Erdine","year":"2009","journal-title":"Pain Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5554631","DOI":"10.1155\/2021\/5554631","article-title":"Intra-Articular Application of Sluijter-Teixera Poisson Pulsed Radiofrequency in Symptomatic Patients with Knee Osteoarthritis: Focus upon Clinical Efficacy and Safety","volume":"2021","author":"Filippiadis","year":"2021","journal-title":"Pain Res. Manag."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5812\/aapm.10259","article-title":"The Treatment of Joint Pain with Intra-articular Pulsed Radiofrequency","volume":"3","author":"Schianchi","year":"2013","journal-title":"Anesth. Pain Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e97372","DOI":"10.5812\/aapm.97372","article-title":"Effects of Pulsed Radiofrequency on a Standard Model of Muscle Injury in Rats","volume":"10","author":"Brasil","year":"2020","journal-title":"Anesth. Pain Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sluijter, M.E., Teixeira, A., Vissers, K., Brasil, L.J., and van Duijn, B. (2023). The Anti-Inflammatory Action of Pulsed Radiofrequency-A Hypothesis and Potential Applications. Med. Sci., 11.","DOI":"10.3390\/medsci11030058"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2147\/JPR.S317569","article-title":"Intraarticular STP Radiofrequency for Painful Osteoarthritis in the Knee: A Retrospective Single Center Analysis","volume":"14","author":"Papa","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jorge, D.M.F., Huber, S.C., Rodrigues, B.L., Da Fonseca, L.F., Azzini, G.O.M., Parada, C.A., Paulus-Romero, C., and Lana, J.F.S.D. (2022). The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911726"},{"key":"ref_16","first-page":"525","article-title":"Pulsed Radiofrequency in Interventional Pain Management: Cellular and Molecular Mechanisms of Action\u2014An Update and Review","volume":"24","author":"Sam","year":"2021","journal-title":"Pain Physician"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1533-2500.2010.00389.x","article-title":"9. Painful shoulder complaints","volume":"10","author":"Huygen","year":"2010","journal-title":"Pain Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1526-5900(03)00554-6","article-title":"Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy","volume":"4","author":"Cahana","year":"2003","journal-title":"J. Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1533-2500.2002.02033.x","article-title":"Radiofrequency treatment of peripheral nerves","volume":"2","author":"Rohof","year":"2002","journal-title":"Pain Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1526-4637.2006.00138.x","article-title":"Intradiscal high-voltage, long-duration pulsed radiofrequency for discogenic pain: A preliminary report","volume":"7","author":"Teixeira","year":"2006","journal-title":"Pain Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s004220050563","article-title":"Computational model of the effects of stochastic conditioning on the induction of long-term potentiation and depression","volume":"81","author":"Migliore","year":"1999","journal-title":"Biol. Cybern."},{"key":"ref_22","first-page":"1","article-title":"The efficacy of pulsed radiofrequency stimulation of the glenohumeral joint and suprascapular nerve for chronic shoulder pain and function compared to physiotherapy and exercise program without pain management","volume":"1","author":"Jauhiainen","year":"2021","journal-title":"Arch. Clin. Trials."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/AJP.0b013e3181d92a87","article-title":"Transcutaneous Pulsed Radiofrequency Treatment in Patients with Painful Knee Awaiting Total Knee Joint Replacement","volume":"26","author":"Taverner","year":"2010","journal-title":"Clin. J. Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5812\/aapm.10242","article-title":"Intravenous application of pulsed radiofrequency-4 case reports","volume":"3","author":"Teixeira","year":"2013","journal-title":"Anesth. Pain Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1526-4637.2005.00076.x","article-title":"Electric and thermal field effects in tissue around radiofrequency electrodes","volume":"6","author":"Cosman","year":"2005","journal-title":"Pain Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.semcdb.2008.12.009","article-title":"Electrical fields in wound healing-An overriding signal that directs cell migration","volume":"20","author":"Zhao","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/papr.12059","article-title":"Transcutaneous pulsed radiofrequency treatment for patients with shoulder pain booked for surgery: A double-blind, randomized controlled trial","volume":"14","author":"Taverner","year":"2014","journal-title":"Pain Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5114\/ms.2024.138016","article-title":"Efficacy of osteopathic manipulative treatment (93.6. ICD\u20139)\u2014Systematic review","volume":"40","author":"Dwornik","year":"2024","journal-title":"Med. Stud."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Miko\u0142ajczyk-Koci\u0119cka, A., Koci\u0119cki, M., Cyry\u0142owski, L., Szyli\u0144ska, A., Rynio, P., G\u0119bska, M., Szuba, E., and Ka\u017amierczak, J. (2024). Assessment of the Effectiveness of Fascial Manipulation in Patients with Degenerative Disc Disease of the Lumbosacral Spine. Life, 15.","DOI":"10.3390\/life15010033"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3171\/2024.1.SPINE231079","article-title":"Transcutaneous electrical nerve stimulation for the treatment of acute postoperative pain following spine surgery: A scoping review","volume":"41","author":"Lee","year":"2024","journal-title":"J. Neurosurg. 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