{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:16:58Z","timestamp":1789431418622,"version":"build-2803163510"},"reference-count":70,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["CNPq N\u00ba 35\/2023"],"award-info":[{"award-number":["CNPq N\u00ba 35\/2023"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"crossref","award":["FAPERJ N\u00ba E_13\/2023"],"award-info":[{"award-number":["FAPERJ N\u00ba E_13\/2023"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brazilian Army","award":["DECEx\/Ex N\u00ba 457"],"award-info":[{"award-number":["DECEx\/Ex N\u00ba 457"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES N\u00ba14\/2021"],"award-info":[{"award-number":["CAPES N\u00ba14\/2021"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JFMK"],"abstract":"<jats:p>Background: Physical conditioning is essential to meet the operational demands of military environments. However, high-intensity exercise provokes muscle microinjuries resulting in exercise-induced muscle damage. This condition is typically monitored using serum biomarkers such as creatine kinase (CK), myoglobin (MYO), and lactate dehydrogenase (LDH). Nevertheless, individual variability and genetic factors complicate the interpretation. In this context, the rs1815739 variant (ACTN3), the most common variant related to exercise phenotypes, hypothetically could interfere with the muscle physiological response. This study aimed to evaluate the kinetics of serum biomarkers during a high-intensity activity and their potential association with rs1815739 polymorphism. Materials and Methods: 32 male cadets were selected during the Army Paratrooper Course. Serum was obtained at six distinct moments while they performed regular course tests and recovery time. Borg scale was assessed in 2 moments (~11 and ~17). Results: Serum levels of CK, CK-MB, MYO, and LDH significantly increase after exercise, proportionally to Borg\u2019s level, following the applicability of longitudinal studies to understand biomarker levels in response to exercise. R allele carriers (ACTN3) were only slightly associated with greater levels of MYO and CK, mainly in relative kinetic levels, and especially at moments of greater physical demand\/recovery. Although the ACTN3 was slightly related to different biomarker levels in our investigation, the success or healthiness in military activities is multifactorial and does not depend only on interindividual variability or physical capacity. Conclusions: Monitoring biomarkers and multiple genomic regions can generate more efficient exercise-related phenotype interventions.<\/jats:p>","DOI":"10.3390\/jfmk10040381","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T08:20:28Z","timestamp":1759393228000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Kinetics of Serum Myoglobin and Creatine Kinase Related to Exercise-Induced Muscle Damage and ACTN3 Polymorphism in Military Paratroopers Under Intense Exercise"],"prefix":"10.3390","volume":"10","author":[{"given":"Rachel de S.","family":"Augusto","sequence":"first","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"},{"name":"Clinical Analyses Laboratory, Hospital Central do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0948-9112","authenticated-orcid":false,"given":"Adrieli","family":"Dill","sequence":"additional","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6115-6351","authenticated-orcid":false,"given":"Eliezer","family":"Souza","sequence":"additional","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-9500","authenticated-orcid":false,"given":"Tatiana L. S.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego V.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Running, School of Physical Education and Sport, Universidade Federal do Rio de Janeiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Paiva","sequence":"additional","affiliation":[{"name":"Teaching Division, Parachutist Instruction Center General Penha Brasil, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Dornelas-Ribeiro","sequence":"additional","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb G. M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Molecular Diagnostic Laboratory, Instituto de Biologia do Ex\u00e9rcito, Ex\u00e9rcito Brasileiro, Rio de Janeiro 20911-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cameron, K.L., and Owens, B.D. (2016). Musculoskeletal Injuries in the Military Training Environment. Musculoskeletal Injuries in the Military, Springer.","DOI":"10.1007\/978-1-4939-2984-9"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/oemed-2016-103684","article-title":"Fitness Tests and Occupational Tasks of Military Interest: A Systematic Review of Correlations","volume":"74","author":"Hauschild","year":"2017","journal-title":"Occup. Environ. 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