{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:09:28Z","timestamp":1785798568968,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFMK"],"abstract":"<jats:p>Background: The change over time of certain inflammatory markers, such as the neutrophil\u2013lymphocyte ratio (NLR) and systemic inflammatory response index (SIRI), is a prognostic factor in many cancers, including breast cancer. This study retrospectively evaluated how a 12-week intensive exercise program might have influenced both the NLR and SIRI in women with breast cancer. Methods: Two institutional review board-approved prospective clinical trials, EXERT-BC (NCT05747209, 2 November 2022) and EXERT-BCN (NCT05978960, 31 July 2023), were retrospectively assessed. Complete blood count (CBC) values performed before and after participation in a 12-week intensive resistance program were analyzed post hoc. Blood tests were ordered as part of routine clinical care and not pre-specified by either study protocol. Participants who had blood work more than four months from study intake or completion were excluded. Additionally, those undergoing active systemic therapy or with underlying inflammatory conditions were also excluded. The NLR and SIRI values were analyzed via the Mann\u2013Whitney test, with pair-wise assessment of pre- and post-intervention values via the Wilcoxon signed-rank test. Results: Out of 84 participants, 21 people met the inclusion criteria. Roughly 70% had either ductal carcinoma in situ (DCIS) or early-stage breast cancer. The average blood draw was taken within two months of study intake and outtake. After the 12-week structured exercise program, there was an associated reduction in both the NLR (2.26 [IQR, 1.70\u20134.22] to 1.99 [1.44\u20132.62]; \u0394NLR = \u22120.27, W = 47.0, p = 0.016) and SIRI (1.23 [0.82\u20131.64] to 0.80 [0.59\u20131.45]; \u0394SIRI = \u22120.43, W = 48.0, p = 0.018). Of those who saw their inflammatory markers improve, roughly two thirds showed a clinically relevant improvement. Conclusions: Completion of a 12-week intensive resistance exercise program was associated with a statistically improved NLR and SIRI. The small sample size and retrospective nature limit the broader application of these findings. The results, however, provide a genesis for prospective validation examining the potential benefit exercise might have on the NLR and SIRI in women with breast cancer.<\/jats:p>","DOI":"10.3390\/jfmk10040436","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:51:08Z","timestamp":1762782668000},"page":"436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Dynamic Change in the Neutrophil\u2013Lymphocyte Ratio and Systemic Inflammatory Response Index After Undergoing an Intensive Resistance-Based Exercise Program"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3037-2230","authenticated-orcid":false,"given":"Timothy P.","family":"Dougherty","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA 15212, USA"},{"name":"Allegheny Health Network Cancer Institute, Exercise Oncology and Resiliency Center, Pittsburgh, PA 15202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, WellStar Paulding Medical Center, Hiram, GA 30141, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Peluso","sequence":"additional","affiliation":[{"name":"Allegheny Health Network Cancer Institute, Exercise Oncology and Resiliency Center, Pittsburgh, PA 15202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1879-7463","authenticated-orcid":false,"given":"Colin E.","family":"Champ","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA 15212, USA"},{"name":"Allegheny Health Network Cancer Institute, Exercise Oncology and Resiliency Center, Pittsburgh, PA 15202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e183605","DOI":"10.1001\/jamanetworkopen.2018.3605","article-title":"Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing","volume":"1","author":"Mandsager","year":"2018","journal-title":"JAMA Network Open"},{"key":"ref_2","first-page":"580","article-title":"The role of physical activity in cancer prevention, treatment, recovery, and survivorship","volume":"27","author":"Lemanne","year":"2013","journal-title":"Oncology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/jnci\/djaa046","article-title":"Physical activity before, during, and after chemotherapy for high-risk breast cancer: Relationships with survival","volume":"113","author":"Cannioto","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dougherty, T.P., and Meyer, J.E. (2023). Comparing lifestyle modifications and the magnitude of their associated benefit on cancer mortality. Nutrients, 15.","DOI":"10.3390\/nu15092038"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s11764-021-01080-0","article-title":"Implementation barriers to integrating exercise as medicine in oncology: An ecological scoping review","volume":"16","author":"Kennedy","year":"2022","journal-title":"J. Cancer Surviv. Res. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa2502760","article-title":"Structured exercise after adjuvant chemotherapy for colon cancer","volume":"393","author":"Courneya","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Forget, P., Khalifa, C., Defour, J.-P., Latinne, D., Van Pel, M.-C., and De Kock, M. (2017). What is the normal value of the neutrophil-to-lymphocyte ratio?. BMC Res. Notes, 10.","DOI":"10.1186\/s13104-016-2335-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"75381","DOI":"10.18632\/oncotarget.18856","article-title":"Prognostic role of systemic immune-inflammation index in solid tumors: A systematic review and meta-analysis","volume":"8","author":"Zhong","year":"2017","journal-title":"Oncotarget"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kim, J.-Y., Jung, E.J., Kim, J.-M., Lee, H.S., Kwag, S.-J., Park, J.-H., Park, T., Jeong, S.-H., Jeong, C.-Y., and Ju, Y.-T. (2020). Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07700-9"},{"key":"ref_10","first-page":"537","article-title":"Prognostic value of the systemic inflammation response index (Siri) before and after surgery in operable breast cancer patients","volume":"28","author":"Wang","year":"2020","journal-title":"Cancer Biomark. Sect. A Dis. Markers"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.jacc.2004.12.077","article-title":"The effects of physical activity on serum C-reactive protein and inflammatory markers: A systematic review","volume":"45","author":"Kasapis","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00421-021-04668-7","article-title":"Transferring clinically established immune inflammation markers into exercise physiology: Focus on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index","volume":"121","author":"Walzik","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1055\/s-0031-1283185","article-title":"Diet and exercise improve neutrophil to lymphocyte ratio in overweight adolescents","volume":"32","author":"Wang","year":"2011","journal-title":"Int. J. Sports Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bjps.2024.05.032","article-title":"Effect of aerobic exercise on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lymphocyte-monocyte ratio in burn patients: A randomized controlled trial","volume":"95","year":"2024","journal-title":"J. Plast. Reconstr. Aesthetic Surg. JPRAS"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Carpenter, D.J., Peluso, C., Hilton, C., Coopey, S.B., Gomez, J., Rosenberg, J., Beriwal, S., Hyde, P.N., and Champ, C.E. (2025). Exert-bcn: An exercise regimen designed to improve body composition, functional capacity, and strength after treatment for breast cancer with nutrition optimization. JCO Oncol. Pract., OP-24-00954.","DOI":"10.1200\/OP-24-00954"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e7001","DOI":"10.1002\/cam4.7001","article-title":"EXERT-BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer","volume":"13","author":"Carpenter","year":"2024","journal-title":"Cancer Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/cncr.30057","article-title":"A novel systemic inflammation response index (Siri) for predicting the survival of patients with pancreatic cancer after chemotherapy","volume":"122","author":"Qi","year":"2016","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chao, B., Ju, X., Zhang, L., Xu, X., and Zhao, Y. (2020). A novel prognostic marker systemic inflammation response index (Siri) for operable cervical cancer patients. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00766"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.intimp.2018.10.002","article-title":"A novel systemic inflammation response index (Siri) for predicting postoperative survival of patients with esophageal squamous cell carcinoma","volume":"65","author":"Geng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00270-021-02965-4","article-title":"A systemic inflammation response index (Siri)-based nomogram for predicting the recurrence of early stage hepatocellular carcinoma after radiofrequency ablation","volume":"45","author":"Xin","year":"2022","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liu, Z., Ge, H., Miao, Z., Shao, S., Shi, H., and Dong, C. (2021). Dynamic changes in the systemic inflammation response index predict the outcome of resectable gastric cancer patients. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.577043"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/bjc.2015.183","article-title":"Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer","volume":"113","author":"Koh","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbi.2005.04.001","article-title":"Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: A randomized controlled trial","volume":"19","author":"Fairey","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10549-016-3688-0","article-title":"The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: A randomized controlled trial","volume":"155","author":"Hagstrom","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"suaf083.029","DOI":"10.1093\/eurheartjsupp\/suaf083.029","article-title":"Long-term exercise adherence and body composition after completion of an intense resistance training regimen during and after treatment for breast cancer","volume":"27","author":"Champ","year":"2025","journal-title":"Eur. Heart J. Suppl."}],"container-title":["Journal of Functional Morphology and Kinesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5142\/10\/4\/436\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T14:26:21Z","timestamp":1762784781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5142\/10\/4\/436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,8]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jfmk10040436"],"URL":"https:\/\/doi.org\/10.3390\/jfmk10040436","relation":{},"ISSN":["2411-5142"],"issn-type":[{"value":"2411-5142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,8]]}}}