{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:41:35Z","timestamp":1774680095731,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vertex Pharmaceuticals\u2019 Vertex Innovation Award"},{"DOI":"10.13039\/100018232","name":"Orphan Disease Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018232","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UAB CF Research Center, Core C","award":["P30DK072482"],"award-info":[{"award-number":["P30DK072482"]}]},{"name":"UAB Research and Development Program","award":["DAVIS24RO"],"award-info":[{"award-number":["DAVIS24RO"]}]},{"name":"Telehealth COPD","award":["UH3HL155806"],"award-info":[{"award-number":["UH3HL155806"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFMK"],"abstract":"<jats:p>Background: The Cystic Fibrosis Foundation (CFF) recognizes exercise as a critical part of managing cystic fibrosis (CF). This becomes even more important in the era of highly effective modulator therapy (HEMT) due to many people with cystic fibrosis (pwCF) having decreased symptom burden and a newfound ability to tolerate exercise better. Our single-center pilot study was designed to assess the implementation of a remotely delivered, individualized, and comprehensive exercise program for pwCF. We aimed to determine the feasibility, safety and acceptance of this intervention. Methods: PwCF \u2265 18 years old were recruited and consented at the University of Alabama in Birmingham in 2022 and 2023. Basic fitness was assessed for each participant, and an individualized exercise prescription was prepared for each participant, who was expected to exercise three times weekly on a remote basis with the exercise physiologist for 12 consecutive weeks. Subjects were reassessed at 4 and 7 months for post-exercise evaluation. Patient demographics and clinical parameters, including exacerbation rate, FEV1 percent predicted, 6-min walk test (6MWT), and modified shuttle test (MST) were collected. Questionnaire data from the CFQ-R, PRAISE, and IPAQ were also recorded. The study was registered with ClinicalTrials.gov (NCT04680403) and was submitted on 17 December 2020. Results: Our goal was to enroll 12 participants over the 2-year study period. We were able to recruit nine people for the study, with four participants finishing the program. From the 36 sessions offered over the 12-week program, participants completed an average of 15 sessions. Clinical outcome data was observed, including lung function and exacerbation frequency, but not statistically analyzed due to the small sample size. Conclusions: Implementation of an individualized telehealth-based exercise program for pwCF was well received by participants, safe, and appreciated by the participants. Recruitment and adherence were challenging, which was partially due to the ongoing pandemic. Follow-up studies are needed to assess whether improvements in reducing the amount or supervision of weekly exercise sessions and\/or extending the total time might help with adherence.<\/jats:p>","DOI":"10.3390\/jfmk11020136","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:37:15Z","timestamp":1774532235000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot and Feasibility Study of an Individualized Telehealth Exercise Program for People with Cystic Fibrosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Jordan","family":"Saag","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna","family":"Bailey","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Monroe","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Hathorne","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-6236","authenticated-orcid":false,"given":"John D.","family":"Lowman","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Department of Physical Therapy, School of Health Professions, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surya P.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Garcia","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-6768","authenticated-orcid":false,"given":"Stefanie","family":"Krick","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000439057","article-title":"Statement on Exercise Testing in Cystic Fibrosis","volume":"90","author":"Hebestreit","year":"2015","journal-title":"Respiration"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1378\/chest.125.1_suppl.1S","article-title":"Cystic fibrosis adult care: Consensus conference report","volume":"125","author":"Yankaskas","year":"2004","journal-title":"Chest"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Snodgrass, S.M., Cihil, K.M., Cornuet, P.K., Myerburg, M.M., and Swiatecka-Urban, A. (2013). Tgf-beta1 inhibits Cftr biogenesis and prevents functional rescue of DeltaF508-Cftr in primary differentiated human bronchial epithelial cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063167"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.201404-0703OC","article-title":"Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis","volume":"190","author":"Rowe","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jcf.2024.08.007","article-title":"Cystic fibrosis foundation position paper: Redefining the CF care model","volume":"23","author":"Goetz","year":"2024","journal-title":"J. Cyst. Fibros."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/17476348.2017.1280399","article-title":"Adherence to therapies in cystic fibrosis: A targeted literature review","volume":"11","author":"Narayanan","year":"2017","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1378\/chest.13-1926","article-title":"Pulmonary medication adherence and health-care use in cystic fibrosis","volume":"146","author":"Quittner","year":"2014","journal-title":"Chest"},{"key":"ref_8","first-page":"CD002768","article-title":"Physical activity and exercise training in cystic fibrosis","volume":"8","author":"Radtke","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-0042-1758729","article-title":"Exercise and Airway Clearance Techniques in Cystic Fibrosis","volume":"44","author":"Ward","year":"2023","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1002\/ppul.25734","article-title":"Airway clearance and exercise for people with cystic fibrosis: Balancing longevity with life","volume":"57","author":"Rowbotham","year":"2022","journal-title":"Pediatr. Pulmonol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ppul.10430","article-title":"Exercise testing and training in German CF centers","volume":"37","author":"Barker","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"ref_12","first-page":"CD002768","article-title":"Physical exercise training for cystic fibrosis","volume":"11","author":"Radtke","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jcf.2024.09.011","article-title":"Cystic fibrosis foundation position paper: Redefining the cystic fibrosis care team","volume":"23","author":"Brown","year":"2024","journal-title":"J. Cyst. Fibros."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1249\/MSS.0b013e3182a038b9","article-title":"Exercise dose, exercise adherence, and associated health outcomes in the TIGER study","volume":"46","author":"Miller","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1164\/rccm.201902-0314LE","article-title":"Video Telehealth Pulmonary Rehabilitation Intervention in Chronic Obstructive Pulmonary Disease Reduces 30-Day Readmissions","volume":"200","author":"Bhatt","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/PHM.0000000000000667","article-title":"Aerobic Exercise Training in Very Severe Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis","volume":"96","author":"Paneroni","year":"2017","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1378\/chest.128.4.2347","article-title":"Development and validation of The Cystic Fibrosis Questionnaire in the United States: A health-related quality-of-life measure for cystic fibrosis","volume":"128","author":"Quittner","year":"2005","journal-title":"Chest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1378\/chest.10-2649","article-title":"Measuring a change in self-efficacy following pulmonary rehabilitation: An evaluation of the PRAISE tool","volume":"140","author":"Vincent","year":"2011","journal-title":"Chest"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1055\/s-0039-1697975","article-title":"Acute Pulmonary Exacerbations in Cystic Fibrosis","volume":"40","author":"Goss","year":"2019","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0140-6736(20)32542-3","article-title":"Cystic fibrosis","volume":"397","author":"Shteinberg","year":"2021","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1164\/rccm.202108-1986OC","article-title":"Clinical Effectiveness of Elexacaftor\/Tezacaftor\/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial","volume":"205","author":"Nichols","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1164\/rccm.202106-1419OC","article-title":"Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF)","volume":"205","author":"Hebestreit","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.7326\/M21-2388","article-title":"Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs with Online Education on Outcomes of Knee Osteoarthritis: A Randomized Trial","volume":"175","author":"Bennell","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17534666241235054","DOI":"10.1177\/17534666241235054","article-title":"Perceived burden of respiratory physiotherapy in people with cystic fibrosis taking elexacaftor-tezacaftor-ivacaftor combination: A 1-year observational study","volume":"18","author":"Blardone","year":"2024","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/rccm.202204-0643OC","article-title":"Long-term Telerehabilitation or Unsupervised Training at Home for Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial","volume":"207","author":"Zanaboni","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jcf.2017.05.011","article-title":"A single bout of maximal exercise improves lung function in patients with cystic fibrosis","volume":"16","author":"Tucker","year":"2017","journal-title":"J. Cyst. Fibros."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1067\/mpd.2000.103408","article-title":"A randomized controlled trial of a 3-year home exercise program in cystic fibrosis","volume":"136","author":"Pollock","year":"2000","journal-title":"J. Pediatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1136\/thx.2003.015313","article-title":"Individualised unsupervised exercise training in adults with cystic fibrosis: A 1 year randomised controlled trial","volume":"59","author":"Moorcroft","year":"2004","journal-title":"Thorax"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1249\/MSS.0000000000001104","article-title":"Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis","volume":"49","author":"Beaudoin","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.jcf.2016.09.010","article-title":"Coronary artery disease in cystic fibrosis: An emerging concern?","volume":"15","author":"Skolnik","year":"2016","journal-title":"J. Cyst. Fibros."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/MCP.0b013e32833e8700","article-title":"Update on cystic fibrosis-related diabetes","volume":"16","author":"Stecenko","year":"2010","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Collaco, J.M., Blackman, S.M., Raraigh, K.S., Morrow, C.B., Cutting, G.R., and Paranjape, S.M. (2014). Self-reported exercise and longitudinal outcomes in cystic fibrosis: A retrospective cohort study. BMC Pulm. Med., 14.","DOI":"10.1186\/1471-2466-14-159"}],"container-title":["Journal of Functional Morphology and Kinesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5142\/11\/2\/136\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:14:56Z","timestamp":1774674896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5142\/11\/2\/136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jfmk11020136"],"URL":"https:\/\/doi.org\/10.3390\/jfmk11020136","relation":{},"ISSN":["2411-5142"],"issn-type":[{"value":"2411-5142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}