{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:51:00Z","timestamp":1785775860661,"version":"3.56.0"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Research Project Grant (PIACERI Found\u2014Real-CORNEA), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Funct. Morphol. Kinesiol.","JFMK"],"abstract":"<jats:p>The cerebellum plays a key role in regulating movement, coordination, and certain cognitive functions. Purkinje cells are the principal neurons of the cerebellum, essential for integrating information and modulating output to other parts of the central nervous system. Physical exercise is crucial for maintaining psychophysical well-being and improving quality of life. Moreover, its beneficial effects on brain health are well established. After a brief overview of cerebellar anatomy, this narrative review aims to summarize current experimental evidence on the effects of physical activity on Purkinje cells, particularly in the context of neuronal plasticity and neuroprotection. Special attention is given to structural and functional adaptations under both physiological and pathological conditions, including neurodegenerative diseases, neurodevelopmental disorders, traumatic brain injury, and aging. Overall, the available findings suggest that Purkinje cells represent a key cellular target of exercise-induced cerebellar plasticity. Physical activity may therefore contribute to preserving cerebellar function and promoting neuroprotection through mechanisms involving structural remodeling and synaptic adaptation of Purkinje cells.<\/jats:p>","DOI":"10.3390\/jfmk11030307","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:51:23Z","timestamp":1785772283000},"page":"307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection"],"prefix":"10.3390","volume":"11","author":[{"given":"Nicoletta","family":"Palmeri","sequence":"first","affiliation":[{"name":"Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata Grazia","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1022-4436","authenticated-orcid":false,"given":"Daniela Maria","family":"Ras\u00e0","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-8890","authenticated-orcid":false,"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-8265","authenticated-orcid":false,"given":"Velia","family":"D\u2019Agata","sequence":"additional","affiliation":[{"name":"Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-4885","authenticated-orcid":false,"given":"Grazia","family":"Maugeri","sequence":"additional","affiliation":[{"name":"Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Safaeipour, C., Sherzai, D., and Zikria, B. (Am. J. Lifestyle Med., 2026). Exercise and Brain Health: Expert Review, Am. J. Lifestyle Med., Online ahead of print.","DOI":"10.1177\/15598276251415530"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120326","DOI":"10.1016\/j.jns.2022.120326","article-title":"Brain health as a global priority","volume":"439","author":"Kolappa","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_3","first-page":"402","article-title":"Physical exercise, cognition, and brain health in aging","volume":"47","author":"Barha","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s13311-019-00749-w","article-title":"Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose","volume":"16","author":"Cabral","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1007\/s12035-023-03492-8","article-title":"Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements","volume":"60","author":"Arrifano","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"Kempermann","year":"1999","journal-title":"Nat. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"Christie","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1523\/JNEUROSCI.21-05-01628.2001","article-title":"Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus","volume":"21","author":"Trejo","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2003.03041.x","article-title":"VEGF is necessary for exercise-induced adult hippocampal neurogenesis","volume":"18","author":"Fabel","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.31083\/j.jin2312216","article-title":"Addressing the Effect of Exercise on Glial Cells: Focus on Ependymal Cells","volume":"23","author":"Maugeri","year":"2024","journal-title":"J. Integr. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.4103\/1673-5374.373683","article-title":"Role of exercise in the brain: Focus on oligodendrocytes and remyelination","volume":"18","author":"Maugeri","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1001\/jama.292.12.1454","article-title":"Physical activity, including walking, and cognitive function in older women","volume":"292","author":"Weuve","year":"2004","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.apmr.2004.03.019","article-title":"The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis","volume":"85","author":"Heyn","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7326\/0003-4819-144-2-200601170-00004","article-title":"Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older","volume":"144","author":"Larson","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sortino, M., Petrigna, L., Trovato, B., Amato, A., Castorina, A., D\u2019Agata, V., Maugeri, G., and Musumeci, G. (2023). An Overview of Physical Exercise Program Protocols and Effects on the Physical Function in Multiple Sclerosis: An Umbrella Review. J. Funct. Morphol. Kinesiol., 8.","DOI":"10.3390\/jfmk8040154"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Trovato, B., Magr\u00ec, B., Castorina, A., Maugeri, G., D\u2019Agata, V., and Musumeci, G. (2022). Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington\u2019s Disease. J. Funct. Morphol. Kinesiol., 7.","DOI":"10.3390\/jfmk7020040"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Maugeri, G., and D\u2019Agata, V. (2020). Effects of Physical Activity on Amyotrophic Lateral Sclerosis. J. Funct. Morphol. Kinesiol., 5.","DOI":"10.3390\/jfmk5020029"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Vizzi, L., Padua, E., D\u2019Amico, A.G., Tancredi, V., D\u2019Arcangelo, G., Cariati, I., Scimeca, M., Maugeri, G., D\u2019Agata, V., and Montorsi, M. (2020). Beneficial Effects of Physical Activity on Subjects with Neurodegenerative Disease. J. Funct. Morphol. Kinesiol., 5.","DOI":"10.3390\/jfmk5040094"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e08281","DOI":"10.1016\/j.heliyon.2021.e08281","article-title":"The role of exercise on peripheral nerve regeneration: From animal model to clinical application","volume":"7","author":"Maugeri","year":"2021","journal-title":"Heliyon"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Maugeri, G., D\u2019Agata, V., Magr\u00ec, B., Roggio, F., Castorina, A., Ravalli, S., Di Rosa, M., and Musumeci, G. (2021). Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes. Cells, 10.","DOI":"10.3390\/cells10061542"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s11064-006-9211-y","article-title":"Randomized clinical stroke rehabilitation trials in 2005","volume":"32","author":"Rabadi","year":"2007","journal-title":"Neurochem. Res."},{"key":"ref_23","first-page":"488","article-title":"The Scientific Foundation for the Physical Activity Guidelines for Americans, 2nd Edition","volume":"15","author":"Powell","year":"2018","journal-title":"J. Phys. Act. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2009.08.046","article-title":"Cognitive impairment in major depression","volume":"626","author":"Marazziti","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maugeri, G., and Musumeci, G. (2021). Adapted Physical Activity to Ensure the Physical and Psychological Well-Being of COVID-19 Patients. J. Funct. Morphol. Kinesiol., 6.","DOI":"10.3390\/jfmk6010013"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101868","DOI":"10.1016\/j.arr.2023.101868","article-title":"Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms","volume":"86","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114676","DOI":"10.1016\/j.physbeh.2024.114676","article-title":"Aerobic exercise modulates RIPK1-mediated MAP3K5\/JNK and NF-\u03baB pathways to suppress microglia activation and neuroinflammation in the hippocampus of D-gal-induced accelerated aging mice","volume":"286","author":"Liu","year":"2024","journal-title":"Physiol. Behav."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mu, L., Xia, D., Cai, J., Gu, B., Liu, X., Friedman, V., Liu, Q.-S., and Zhao, L. (2022). Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 \u00d7 Tg-AD Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012655"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Arida, R.M., and Teixeira-Machado, L. (2020). The Contribution of Physical Exercise to Brain Resilience. Front. Behav. Neurosci., 14.","DOI":"10.3389\/fnbeh.2020.626769"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.neubiorev.2013.04.005","article-title":"Beneficial effects of physical exercise on neuroplasticity and cognition","volume":"37","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1515\/revneuro-2020-0099","article-title":"Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins","volume":"32","author":"Liang","year":"2021","journal-title":"Rev. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: Key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2006.02.084","article-title":"Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function","volume":"140","author":"Ding","year":"2006","journal-title":"Neuroscience"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/156720206775541787","article-title":"Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise","volume":"3","author":"Ding","year":"2006","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1113\/JP274658","article-title":"Exercise makes your brain bigger: Skeletal muscle VEGF and hippocampal neurogenesis","volume":"595","author":"Ballard","year":"2017","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/1467-9280.t01-1-01430","article-title":"Fitness effects on the cognitive function of older adults: A meta-analytic study","volume":"14","author":"Colcombe","year":"2003","journal-title":"Psychol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jonasson, L.S., Nyberg, L., Kramer, A.F., Lundquist, A., Riklund, K., and Boraxbekk, C.J. (2016). Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study. Front. Aging Neurosci., 8.","DOI":"10.3389\/fnagi.2016.00336"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-201429","article-title":"Neurocognitive Plasticity Is Associated with Cardiorespiratory Fitness Following Physical Exercise in Older Adults with Amnestic Mild Cognitive Impairment","volume":"81","author":"Eisenstein","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kandola, A., Hendrikse, J., Lucassen, P.J., and Y\u00fccel, M. (2016). Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Front. Hum. Neurosci., 10.","DOI":"10.3389\/fnhum.2016.00373"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Erwin, H., and Schreiber, S. (2024). Aerobic and Anaerobic Exercise\u2019s Impact on Cognitive Functions in Eighth Grade Students. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21070833"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhang, K., Jan, Y.K., Liu, Y., Zhao, T., Zhang, L., Liu, R., Liu, J., and Cao, C. (2022). Exercise Intensity and Brain Plasticity: What\u2019s the Difference of Brain Structural and Functional Plasticity Characteristics Between Elite Aerobic and Anaerobic Athletes?. Front. Hum. Neurosci., 16.","DOI":"10.3389\/fnhum.2022.757522"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.482938","article-title":"Exercise during development induces an increase in Purkinje cell dendritic tree size","volume":"206","author":"Pysh","year":"1979","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kraemer, R.R., and Kraemer, B.R. (2023). The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1202349"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Jia, Y., Yao, Y., Zhuo, L., Chen, X., Yan, C., Ji, Y., Tao, J., and Zhu, Y. (2022). Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.862078"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Karamacoska, D., Butt, A., Leung, I.H.K., Childs, R.L., Metri, N.J., Uruthiran, V., Tan, T., Sabag, A., and Steiner-Lim, G.Z. (2023). Brain function effects of exercise interventions for cognitive decline: A systematic review and meta-analysis. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1127065"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/cne.20493","article-title":"Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density","volume":"486","author":"Eadie","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hipo.20348","article-title":"Running induces widespread structural alterations in the hippocampus and entorhinal cortex","volume":"17","author":"Stranahan","year":"2007","journal-title":"Hippocampus"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbr.2006.10.018","article-title":"The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning","volume":"176","author":"Ohle","year":"2007","journal-title":"Behav. Brain Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/bs.pmbts.2015.07.004","article-title":"Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain","volume":"135","author":"Hamilton","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mahalakshmi, B., Maurya, N., Lee, S.D., and Bharath Kumar, V. (2020). Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165895"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Liu, S., Yu, Q., Li, Z., Cunha, P.M., Zhang, Y., Kong, Z., Lin, W., Chen, S., and Cai, Y. (2020). Effects of Acute and Chronic Exercises on Executive Function in Children and Adolescents: A Systemic Review and Meta-Analysis. Front. Psychol., 11.","DOI":"10.3389\/fpsyg.2020.554915"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ncl.2014.07.013","article-title":"The human cerebellum: A review of physiologic neuroanatomy","volume":"32","author":"Roostaei","year":"2014","journal-title":"Neurol. Clin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10143-012-0417-y","article-title":"Three-dimensional microsurgical anatomy of cerebellar peduncles","volume":"36","author":"Perrini","year":"2013","journal-title":"Neurosurg. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00062-023-01326-7","article-title":"Anything but Little: A Pictorial Review on Anatomy and Pathology of the Cerebellum","volume":"33","author":"Dekeyzer","year":"2023","journal-title":"Clin. Neuroradiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e20240001","DOI":"10.1590\/0100-3984.2024.0001","article-title":"Hyperintense lesions of the middle cerebellar peduncle and beyond: A pictorial essay","volume":"57","author":"Tamanini","year":"2024","journal-title":"Radiol. Bras."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/cne.901780307","article-title":"The cerebellofugal projections in the brachium conjunctivum of the rat I. The contralateral ascending pathway","volume":"178","author":"Faull","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-444-63956-1.00006-0","article-title":"Physiology of the cerebellum","volume":"154","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000489943","article-title":"Development and Evolution of Cerebral and Cerebellar Cortex","volume":"91","author":"Donahue","year":"2018","journal-title":"Brain Behav. Evol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"19538","DOI":"10.1073\/pnas.2002896117","article-title":"The human cerebellum has almost 80% of the surface area of the neocortex","volume":"117","author":"Sereno","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Consalez, G.G., Goldowitz, D., Casoni, F., and Hawkes, R. (2020). Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum. Front. Neural Circuits, 14.","DOI":"10.3389\/fncir.2020.611841"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/nimg.1999.0459","article-title":"Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space","volume":"10","author":"Schmahmann","year":"1999","journal-title":"Neuroimage"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00709-012-0407-5","article-title":"Jan Evangelista Purkyn\u011b\/Purkinje (1787\u20131869) and the establishment of cellular physiology--Wroc\u0142aw\/Breslau as a central European cradle for a new science","volume":"249","year":"2012","journal-title":"Protoplasma"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"DeFelipe, J. (2015). The dendritic spine story: An intriguing process of discovery. Front. Neuroanat., 9.","DOI":"10.3389\/fnana.2015.00014"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Abrams, Z.R., and Zhang, X. (2011). Signals and circuits in the purkinje neuron. Front. Neural Circuits, 5.","DOI":"10.3389\/fncir.2011.00011"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez Santoro, E.M., Karim, A., Warnaar, P., De Zeeuw, C.I., Badura, A., and Negrello, M. (2024). Purkinje cell models: Past, present and future. Front. Comput. Neurosci., 18.","DOI":"10.3389\/fncom.2024.1426653"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s42003-023-05689-y","article-title":"Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity","volume":"7","author":"Masoli","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(95)90334-8","article-title":"Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice","volume":"81","author":"Kashiwabuchi","year":"1995","journal-title":"Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00221-006-0654-9","article-title":"Structural and functional alterations of cerebellum following fluid percussion injury in rats","volume":"177","author":"Ai","year":"2007","journal-title":"Exp. Brain Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neulet.2010.06.087","article-title":"Effect of treadmill exercise on Purkinje cell loss and astrocytic reaction in the cerebellum after traumatic brain injury","volume":"481","author":"Seo","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1523\/JNEUROSCI.23-08-03469.2003","article-title":"Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination","volume":"23","author":"Barski","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneuroim.2013.02.018","article-title":"Anti-Purkinje cell antibody as a biological marker in attention deficit\/hyperactivity disorder: A pilot study","volume":"258","author":"Passarelli","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/npp.2013.344","article-title":"The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning","volume":"39","author":"Zhang","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1073\/pnas.96.9.5257","article-title":"Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin","volume":"96","author":"Schiffmann","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"15735","DOI":"10.1523\/JNEUROSCI.4048-09.2009","article-title":"Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1","volume":"29","author":"Hurlock","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/nn.3576","article-title":"Cerebellar Purkinje cell activity drives motor learning","volume":"16","author":"Kimpo","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"13630","DOI":"10.1523\/JNEUROSCI.3226-10.2010","article-title":"Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells","volume":"30","author":"Belmeguenai","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1152\/jn.2000.84.5.2514","article-title":"Floccular modulation of vestibuloocular pathways and cerebellum-related plasticity: An in vitro whole brain study","volume":"84","author":"Babalian","year":"2000","journal-title":"J. Neurophysiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.conb.2011.05.025","article-title":"The multiple roles of Purkinje cells in sensori-motor calibration: To predict, teach and command","volume":"21","author":"Medina","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(77)90997-0","article-title":"Purkinje cell activity during motor learning","volume":"128","author":"Gilbert","year":"1977","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nbd.2010.07.001","article-title":"Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia","volume":"40","author":"Jones","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainresbull.2010.12.001","article-title":"Organotypic slices culture model for cerebellar ataxia: Potential use to study Purkinje cell induction from neural stem cells","volume":"84","author":"Lu","year":"2011","journal-title":"Brain Res. Bull."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1471-4159.2008.05617.x","article-title":"Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization","volume":"107","author":"Kelley","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_84","first-page":"331","article-title":"Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus","volume":"89","author":"Welsh","year":"2002","journal-title":"Adv. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1523\/JNEUROSCI.1451-23.2023","article-title":"Cognitive-Affective Functions of the Cerebellum","volume":"43","author":"Rudolph","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12311-015-0685-5","article-title":"The Errors of Our Ways: Understanding Error Representations in Cerebellar-Dependent Motor Learning","volume":"15","author":"Popa","year":"2016","journal-title":"Cerebellum"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Popa, L.S., Hewitt, A.L., and Ebner, T.J. (2014). The cerebellum for jocks and nerds alike. Front. Syst. Neurosci., 8.","DOI":"10.3389\/fnsys.2014.00113"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tics.2017.02.005","article-title":"The Cerebellum: Adaptive Prediction for Movement and Cognition","volume":"21","author":"Sokolov","year":"2017","journal-title":"Trends Cogn. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Rochefort, C., Lefort, J.M., and Rondi-Reig, L. (2013). The cerebellum: A new key structure in the navigation system. Front. Neural Circuits, 7.","DOI":"10.3389\/fncir.2013.00035"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-444-63356-9.00009-1","article-title":"Cerebellar and prefrontal cortex contributions to adaptation, strategies, and reinforcement learning","volume":"210","author":"Taylor","year":"2014","journal-title":"Prog. Brain Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s12311-017-0850-0","article-title":"The Known and Missing Links Between the Cerebellum, Basal Ganglia, and Cerebral Cortex","volume":"16","author":"Cacciola","year":"2017","journal-title":"Cerebellum"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41583-018-0002-7","article-title":"The basal ganglia and the cerebellum: Nodes in an integrated network","volume":"19","author":"Bostan","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-neuro-100120-092143","article-title":"Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors","volume":"44","author":"Stoodley","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","article-title":"The cerebellum and cognition","volume":"688","author":"Schmahmann","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12311-019-01060-2","article-title":"The Cerebellar Cognitive Affective Syndrome-a Meta-analysis","volume":"18","author":"Ahmadian","year":"2019","journal-title":"Cerebellum"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"258","DOI":"10.12965\/jer.140163","article-title":"Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer\u2019s disease rats","volume":"10","author":"Lee","year":"2014","journal-title":"J. Exerc. Rehabil."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.31083\/j.jin2205117","article-title":"Effect of Physical Exercise on Mitochondrial Dysfunction and Purkinje Cell Survival in the Cerebellum of 3xTg-AD Mice","volume":"22","author":"Jin","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.5213\/inj.1836226.113","article-title":"Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats","volume":"22","author":"Lee","year":"2018","journal-title":"Int. Neurourol. J."},{"key":"ref_99","first-page":"103","article-title":"Pre-treatment aerobic exercises on cerebellar Purkinje cells in Parkinson\u2019s rats with prenatal stress","volume":"9","author":"Azizi","year":"2019","journal-title":"Middle East. J. Disabil. Stud."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.12965\/jer.1632696.348","article-title":"Treadmill exercise ameliorates motor dysfunction through inhibition of Purkinje cell loss in cerebellum of valproic acid-induced autistic rats","volume":"12","author":"Cho","year":"2016","journal-title":"J. Exerc. Rehabil."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"25248","DOI":"10.1038\/s41598-025-09089-6","article-title":"Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK\/PPAR-\u03b3 dependent pathway and improves mitochondrial activity in mice","volume":"15","author":"Shaban","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Maugeri, G., D\u2019Amico, A.G., Federico, C., Saccone, S., D\u2019Agata, V., and Musumeci, G. (2024). Moderate Physical Activity Increases the Expression of ADNP in Rat Brain. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084382"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Maugeri, G., Di Bartolo, S., Palmeri, N., D\u2019Amico, A.G., Brancato, D., Federico, C., D\u2019Agata, V., and Musumeci, G. (2026). Moderate Exercise Stimulates PACAP-Mediated Neurogenesis in Rat Dentate Gyrus and Cerebellar Cortex. J. Funct. Morphol. Kinesiol., 11.","DOI":"10.3390\/jfmk11010037"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neulet.2011.01.043","article-title":"Guided motor training induces dendritic spine plastic changes in adult rat cerebellar purkinje cells","volume":"491","author":"Zamora","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/japplphysiol.01363.2011","article-title":"Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum","volume":"113","author":"Huang","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/1096-9861(20001211)428:2<213::AID-CNE2>3.0.CO;2-Q","article-title":"Does long-term physical exercise counteract age-related Purkinje cell loss? A stereological study of rat cerebellum","volume":"428","author":"Larsen","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0047-6374(96)01707-1","article-title":"Influence of physical exercise on aging rats: I. Life-long exercise preserves patterns of spontaneous activity","volume":"87","author":"Skalicky","year":"1996","journal-title":"Mech. Ageing Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"112481","DOI":"10.1016\/j.bbr.2020.112481","article-title":"Moderate intensity intermittent exercise upregulates neurotrophic and neuroprotective genes expression and inhibits Purkinje cell loss in the cerebellum of ovariectomized rats","volume":"382","author":"Rauf","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"22","DOI":"10.12965\/jer.140092","article-title":"Treadmill exercise ameliorates symptoms of attention deficit\/hyperactivity disorder through reducing Purkinje cell loss and astrocytic reaction in spontaneous hypertensive rats","volume":"10","author":"Yun","year":"2014","journal-title":"J. Exerc. Rehabil."},{"key":"ref_110","first-page":"8121","article-title":"Effect of treadmill exercise on spatial navigation impairment associated with cerebellar Purkinje cell loss following chronic cerebral hypoperfusion","volume":"17","author":"Lee","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Journal of Functional Morphology and Kinesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2411-5142\/11\/3\/307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:17:40Z","timestamp":1785773860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2411-5142\/11\/3\/307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":110,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jfmk11030307"],"URL":"https:\/\/doi.org\/10.3390\/jfmk11030307","relation":{},"ISSN":["2411-5142"],"issn-type":[{"value":"2411-5142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]}}}