{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:42:57Z","timestamp":1760244177224,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFMK"],"abstract":"<jats:p>Interprosthetic humeral fractures (IHFs) are severe injury patterns associated with surgical issues and contradictory results. The knowledge and literature on this topic are still lacking. A 76 year-old woman was treated for a fracture occurred between the shoulder and elbow stemmed prosthesis. Severe bone loss was associated with the fracture. Treatment: Open reduction, plate fixation, and bone grafting were considered. A xenograft (used as a mechanical strut medially), a synthetic graft associated with bone growth factors, and scaffolds improved the bone healing process. Satisfactory clinical and radiological outcomes were obtained. A scoping review of the literature was also performed by the authors. Only eight papers reported IHFs with a low level of evidence. In total, eight patients were treated; one paper that reported on biomechanical aspects using finite element analysis is discussed. Conservative treatment leads to non-union, and the surgical approach is the gold standard. The osteosynthesis technique associated with bone grafting leads to the best outcomes. The use of a xenograft mechanical strut, associated with synthetic biological bone grafting, led to complete bone union at 9 months follow-up. Larger cohorts, more standardised results, and multicentric studies are mandatory in order to improve and establish a management and treatment algorithm.<\/jats:p>","DOI":"10.3390\/jfmk7040094","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"94","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Approach to Treat a Rare Case of Interprosthetic Humeral Fracture with Osteosynthesis and Combined Grafting: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-6531","authenticated-orcid":false,"given":"Fabrizio","family":"Marzano","sequence":"first","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-9157","authenticated-orcid":false,"given":"Valerio","family":"Pace","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"},{"name":"Azienda Ospedaliera Santa Maria Terni, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Donantoni","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Petruccelli","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auro","family":"Caraffa","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo Maria","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Trauma & Orthopaedics Department, Santa Maria della Misericordia Hospital, University of Perugia, 06024 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.3928\/01477447-20180409-05","article-title":"Current Trends in the Use of Shoulder Arthroplasty in the United States","volume":"41","author":"Palsis","year":"2018","journal-title":"Orthopedics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1080\/17453674.2017.1368884","article-title":"International variation in shoulder arthroplasty","volume":"88","author":"Rees","year":"2017","journal-title":"Acta Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0883-5403(98)90041-9","article-title":"Total elbow arthroplasty in primary osteoarthritis of the elbow","volume":"13","author":"Kozak","year":"1998","journal-title":"J. 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