{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:42:58Z","timestamp":1788536578394,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>This study aimed to evaluate our center\u2019s experience in diagnosing and managing placenta accreta spectrum (PAS) in a high-risk population, focusing on prenatal ultrasound features associated with PAS severity and maternal outcomes. We conducted a retrospective analysis of 102 high-risk patients with confirmed placenta previa who delivered at our center between 2018 and 2023. Patients underwent transabdominal and transvaginal ultrasound scans, assessing typical sonographic features. Binary and multivariate logistic regression analyses were performed to identify sonographic markers predictive of PAS and relative complications. Key ultrasound features\u2014retroplacental myometrial thinning (&lt;1 mm), vascular lacunae, and retroplacental vascularization\u2014were significantly associated with PAS and a higher risk of surgical complications. An exceedingly rare sign, the \u201criddled cervix\u201d sign, was observed in only three patients with extensive cervical or parametrial involvement. Those patients had the worst surgical outcomes. This study highlights the utility of specific ultrasound features in stratifying PAS risk and guiding clinical and surgical management in high-risk pregnancies. The findings support integrating these markers into prenatal diagnostic protocols to improve patient outcomes and inform surgical planning.<\/jats:p>","DOI":"10.3390\/jimaging10120315","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T08:40:10Z","timestamp":1733820010000},"page":"315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PAS or Not PAS? The Sonographic Assessment of Placenta Accreta Spectrum Disorders and the Clinical Validation of a New Diagnostic and Prognostic Scoring System"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-1619","authenticated-orcid":false,"given":"Antonella","family":"Vimercati","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9330-6414","authenticated-orcid":false,"given":"Arianna","family":"Galante","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-9745","authenticated-orcid":false,"given":"Margherita","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Chair of Medical Statistic, Department of Interdisciplinary Medicine (DIM), University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7792-8822","authenticated-orcid":false,"given":"Francesca","family":"Cirignaco","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-5435","authenticated-orcid":false,"given":"Amerigo","family":"Vitagliano","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9652-8754","authenticated-orcid":false,"given":"Pierpaolo","family":"Nicol\u00ec","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-8490","authenticated-orcid":false,"given":"Andrea","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and CERICSAL (CEntro di RIcerca Clinico SALentino), Veris Delli Ponti Hospital, 73020 Scorrano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Malvasi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-4648","authenticated-orcid":false,"given":"Miriam","family":"Dellino","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-8068","authenticated-orcid":false,"given":"Gianluca Raffaello","family":"Damiani","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Crescenza","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-8007","authenticated-orcid":false,"given":"Giorgio Maria","family":"Baldini","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-4582","authenticated-orcid":false,"given":"Ettore","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-3608","authenticated-orcid":false,"given":"Marco","family":"Cerbone","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/uog.20246","article-title":"Prenatal ultrasound staging system for placenta accreta spectrum disorders","volume":"53","author":"Cali","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ijgo.12761","article-title":"FIGO Placenta Accreta Diagnosis and Management Expert Consensus Panel FIGO classification for the clinical diagnosis of placenta accreta spectrum disorders","volume":"146","author":"Jauniaux","year":"2019","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1056\/NEJMcp1709324","article-title":"Placenta Accreta Spectrum","volume":"378","author":"Silver","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/jum.15574","article-title":"Diagnosis and Management of Cesarean Scar Pregnancy and Placenta Accreta Spectrum: Case Series and Review of the Literature","volume":"40","author":"Panaitescu","year":"2021","journal-title":"J. Ultrasound Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.37825\/2239-9747.1060","article-title":"Instrumental Diagnosis of Placenta Accreta and Obstetric and Perinatal Outcomes: Literature Review and Observational Study","volume":"26","author":"Castaldi","year":"2024","journal-title":"Transl. Med. UniSa"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/uog.20244","article-title":"Impact of placenta previa with placenta accreta spectrum disorder on fetal growth","volume":"54","author":"Jauniaux","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhan, Y., Lu, E., Xu, T., Huang, G., Deng, C., Chen, T., Ren, Y., Wu, X., Yu, H., and Wang, X. (2024). Cesarean hysterectomy in pregnancies complicated with placenta previa accreta: A retrospective hospital-based study. BMC Pregnancy Childbirth, 24.","DOI":"10.1186\/s12884-024-06834-z"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/GCO.0000000000000811","article-title":"An update of diagnostic efficacy of ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders","volume":"34","author":"Fratelli","year":"2022","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/01443610500040745","article-title":"Pregnancy following endometrial ablation: A review article","volume":"25","author":"Hare","year":"2005","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jmig.2016.10.018","article-title":"Reproductive Outcomes in Patients with Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience from the Largest Women\u2019s Hospital in China","volume":"24","author":"Chen","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fitzpatrick, K.E., Sellers, S., Spark, P., Kurinczuk, J.J., Brocklehurst, P., and Knight, M. (2012). Incidence and risk factors for placenta accreta\/increta\/percreta in the UK: A national case-control study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052893"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bpobgyn.2019.04.006","article-title":"New evidence-based diagnostic and management strategies for placenta accreta spectrum disorders","volume":"61","author":"Jauniaux","year":"2019","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ajog.2014.11.018","article-title":"Center of excellence for placenta accreta","volume":"212","author":"Silver","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000448139","article-title":"Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases","volume":"82","author":"Giorgione","year":"2017","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/aogs.13201","article-title":"Maternal and neonatal outcomes following abnormally invasive placenta: A population-based record linkage study","volume":"96","author":"Baldwin","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.1469-0705.1994.04010007.x","article-title":"Magnetic resonance imaging in pregnancy: Study of fetal cerebral malformations","volume":"4","author":"Resta","year":"1994","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/AOG.0000000000002434","article-title":"Antecedents of Abnormally Invasive Placenta in Primiparous Women: Risk Associated with Gynecologic Procedures","volume":"131","author":"Baldwin","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/aogs.14143","article-title":"Criteria for placenta accreta spectrum in the International Federation of Gynaecology and Obstetrics classification, and topographic invasion area are associated with massive hemorrhage in patients with placenta previa","volume":"100","author":"Ishibashi","year":"2021","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/1471-0528.12524","article-title":"Surgical management of placenta accreta: To leave or remove the placenta?","volume":"121","author":"Wright","year":"2014","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216.e1","DOI":"10.1016\/j.ajog.2012.06.007","article-title":"Preoperative intravascular balloon catheters and surgical outcomes in pregnancies complicated by placenta accreta: A management paradox","volume":"207","author":"Ballas","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/1471-0528.13547","article-title":"Abnormally invasive placenta\u2014Prevalence, risk factors and antenatal suspicion: Results from a large population-based pregnancy cohort study in the Nordic countries","volume":"123","author":"Thurn","year":"2015","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1515\/JPM.1999.043","article-title":"The diagnostic role of \u2018in utero\u2019 magnetic resonance imaging","volume":"27","author":"Vimercati","year":"1999","journal-title":"J. Perinat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/1471-0528.12557","article-title":"The antenatal diagnosis of placenta accreta","volume":"121","author":"Comstock","year":"2013","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.7863\/ultra.33.12.2153","article-title":"Interobserver variability of sonography for prediction of placenta accreta","volume":"33","author":"Bowman","year":"2014","journal-title":"J. Ultrasound Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1600-0412.2011.01147.x","article-title":"Antenatal diagnosis of placenta accreta leads to reduced blood loss","volume":"90","author":"Tikkanen","year":"2011","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"343.e1","DOI":"10.1016\/j.ajog.2014.10.022","article-title":"Ultrasound predictors of placental invasion: The Placenta Accreta Index","volume":"212","author":"Rac","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/uog.14893","article-title":"Accuracy of ultrasound in antenatal diagnosis of placental attachment disorders","volume":"47","author":"Pilloni","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/1742271X20959742","article-title":"Role of placenta accreta index in prediction of morbidly adherent placenta: A reliability study","volume":"29","author":"Agarwal","year":"2021","journal-title":"Ultrasound"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhang, J., Li, H., Feng, D., Wu, J., Wang, Z., and Feng, F. (2023). Ultrasound scoring system for prenatal diagnosis of placenta accreta spectrum. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05886-x"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1471-0528.2008.02037.x","article-title":"Optimal management strategies for placenta accreta","volume":"116","author":"Eller","year":"2009","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177.e1","DOI":"10.1016\/j.ajog.2014.03.029","article-title":"Accuracy of ultrasound for the prediction of placenta accreta","volume":"211","author":"Bowman","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/AOG.0b013e3181c4f12a","article-title":"Effect of predelivery diagnosis in 99 consecutive cases of placenta accreta","volume":"115","author":"Warshak","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"218.e1","DOI":"10.1016\/j.ajog.2014.08.019","article-title":"Maternal morbidity in patients with morbidly adherent placenta treated with and without a standardized multidisciplinary approach","volume":"212","author":"Shamshirsaz","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/ajo.12149","article-title":"Maternal outcome after conservative management of placenta percreta at caesarean section: A report of three cases and a review of the literature","volume":"54","author":"Pather","year":"2013","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/AOG.0000000000000680","article-title":"Morbidly adherent placenta treatments and outcomes","volume":"125","author":"Bailit","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/AOG.0b013e3182051db2","article-title":"Maternal morbidity in cases of placenta accreta managed by a multidisciplinary care team compared with standard obstetric care","volume":"117","author":"Eller","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/AOG.0b013e3181d066d4","article-title":"Maternal outcome after conservative treatment of placenta accreta","volume":"115","author":"Sentilhes","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/uog.15810","article-title":"Pro forma for ultrasound reporting in suspected abnormally invasive placenta (AIP): An international consensus","volume":"47","author":"Alfirevic","year":"2016","journal-title":"Ultrasound Obstet. Gynecol. Off. J. Int. Soc. Ultrasound Obstet. Gynecol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/uog.15813","article-title":"Prediction of morbidly adherent placenta using a scoring system","volume":"48","author":"Tovbin","year":"2016","journal-title":"Ultrasound Obstet. Gynecol. Off. J. Int. Soc. Ultrasound Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.ajog.2004.12.074","article-title":"Abnormal placentation: Twenty-year analysis","volume":"192","author":"Wu","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00404-024-07575-2","article-title":"The sonographic assessment to diagnose Placenta Accreta Spectrum disorders: \u201cRiddled Cervix\u201d and other signs","volume":"310","author":"Vimercati","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/uog.20381","article-title":"Interobserver agreement in MRI assessment of severity of placenta accreta spectrum disorders","volume":"55","author":"Finazzo","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1080\/14767058.2022.2154572","article-title":"Comprehensive surgical staging for placenta accreta spectrum","volume":"35","author":"Basanta","year":"2022","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.7863\/ultra.32.8.1345","article-title":"Prenatal diagnosis of placenta accreta: Is sonography all we need?","volume":"32","author":"Berkley","year":"2013","journal-title":"J. Ultrasound Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/uog.14950","article-title":"Counseling in fetal medicine: Evidence-based answers to clinical questions on morbidly adherent placenta","volume":"47","author":"Lim","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/uog.13327","article-title":"Prenatal identification of invasive placentation using magnetic resonance imaging: Systematic review and meta-analysis","volume":"44","author":"Iacovella","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Riteau, A.-S., Tassin, M., Chambon, G., Le Vaillant, C., de Laveaucoupet, J., Qu\u00e9r\u00e9, M.-P., Joubert, M., Prevot, S., Philippe, H.-J., and Benachi, A. (2014). Accuracy of ultrasonography and magnetic resonance imaging in the diagnosis of placenta accreta. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094866"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.7863\/ultra.15.07040","article-title":"Magnetic Resonance Imaging and Sonography in the Diagnosis of Placental Invasion","volume":"35","author":"Balcacer","year":"2016","journal-title":"J. Ultrasound Med."}],"container-title":["Journal of Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2313-433X\/10\/12\/315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:51:12Z","timestamp":1760115072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2313-433X\/10\/12\/315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jimaging10120315"],"URL":"https:\/\/doi.org\/10.3390\/jimaging10120315","relation":{},"ISSN":["2313-433X"],"issn-type":[{"value":"2313-433X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]}}}