{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:54:19Z","timestamp":1787846059772,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AR078877"],"award-info":[{"award-number":["R01AR078877"]}]},{"name":"NIH","award":["R01AR075825"],"award-info":[{"award-number":["R01AR075825"]}]},{"name":"NIH","award":["R01AR062581"],"award-info":[{"award-number":["R01AR062581"]}]},{"name":"NIH","award":["R01AR068987"],"award-info":[{"award-number":["R01AR068987"]}]},{"name":"NIH","award":["R01AR079484"],"award-info":[{"award-number":["R01AR079484"]}]},{"name":"NIH","award":["RF1AG075717"],"award-info":[{"award-number":["RF1AG075717"]}]},{"name":"VA Clinical Science Research and Development Services","award":["I01CX001388"],"award-info":[{"award-number":["I01CX001388"]}]},{"name":"VA Clinical Science Research and Development Services","award":["I01CX002211"],"award-info":[{"award-number":["I01CX002211"]}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["SE 3272\/6-1"],"award-info":[{"award-number":["SE 3272\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Heidelberg Project Expanding Internationality, Health Resources and Services Administration","award":["H30MC24045"],"award-info":[{"award-number":["H30MC24045"]}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>This study aims to demonstrate the feasibility of ultrashort echo time (UTE)-based susceptibility source separation for musculoskeletal (MSK) imaging, enabling discrimination between diamagnetic and paramagnetic tissue components, with a particular focus on hemophilic arthropathy (HA). Three key techniques were integrated to achieve UTE-based susceptibility source separation: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation for B0 field estimation, projection onto dipole fields for local field mapping, and \u03c7-separation for quantitative susceptibility mapping (QSM) with source decomposition. A phantom containing varying concentrations of diamagnetic (CaCO3) and paramagnetic (Fe3O4) materials was used to validate the method. In addition, in vivo UTE-QSM scans of the knees and ankles were performed on five HA patients using a 3T clinical MRI scanner. In the phantom, conventional QSM underestimated susceptibility values due to the mixed-source cancelling the effect. In contrast, source-separated maps provided distinct diamagnetic and paramagnetic susceptibility values that correlated strongly with CaCO3 and Fe3O4 concentrations (r = \u22120.99 and 0.95, p &lt; 0.05). In vivo, paramagnetic maps enabled improved visualization of hemosiderin deposits in joints of HA patients, which were poorly visualized or obscured in conventional QSM due to susceptibility cancellation by surrounding diamagnetic tissues such as bone. This study demonstrates, for the first time, the feasibility of UTE-based quantitative susceptibility source separation for MSK applications. The approach enhances the detection of paramagnetic substances like hemosiderin in HA and offers potential for improved assessment of bone and joint tissue composition.<\/jats:p>","DOI":"10.3390\/jimaging12010028","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:13:18Z","timestamp":1767697998000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-3718","authenticated-orcid":false,"given":"Sam","family":"Sedaghat","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-4799","authenticated-orcid":false,"given":"Jin Il","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"von Drygalski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-5630","authenticated-orcid":false,"given":"Eric Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-2450","authenticated-orcid":false,"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Nardo","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-9525","authenticated-orcid":false,"given":"Hyungseok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mrm.25358","article-title":"Quantitative Susceptibility Mapping (QSM): Decoding MRI Data for a Tissue Magnetic Biomarker","volume":"73","author":"Wang","year":"2015","journal-title":"Magn. 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