{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:21:48Z","timestamp":1790036508526,"version":"4.0.1"},"reference-count":84,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Neurodegenerative diseases, including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD), are major causes of cognitive and motor decline, yet early diagnosis remains challenging due to asymptomatic phases and limited non-invasive biomarkers. This narrative review systematically synthesized studies on retinal imaging in AD and PD. Published studies were identified through searches of PubMed, MEDLINE, Google Scholar, and reference lists, focusing on Optical Coherence Tomography (OCT), OCT Angiography (OCTA), and Spectral-Domain OCT (SD-OCT) assessing retinal structural and vascular changes. Data were extracted on retinal layer thickness, vascular parameters, and diagnostic metrics. Findings indicate that both diseases consistently exhibit thinning of inner retinal layers, particularly the retinal nerve fiber layer (RNFL) and ganglion cell\u2013inner plexiform layer (GCIPL). In AD, studies reported progressive inner retinal thinning across disease stages, sometimes accompanied by outer retinal and retinal pigment epithelium changes. In PD, thinning was observed predominantly in RNFL and GCIPL, correlating with disease duration and motor severity. Microvascular alterations were described in both disorders, with disease-specific spatial patterns reported across studies. Overall, retinal imaging emerges as a non-invasive, high-resolution, and cost-effective tool for early detection, differential assessment, and longitudinal monitoring of neurodegenerative diseases. These findings support the translation of retinal biomarkers into clinical practice for improved disease management.<\/jats:p>","DOI":"10.3390\/jimaging12030104","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:52:38Z","timestamp":1772207558000},"page":"104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Retina as a Proxy for Brain Neurodegeneration: A Narrative Review on OCT-Based Retinal Imaging in the Early Detection of Alzheimer\u2019s and Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-0229","authenticated-orcid":false,"given":"Ouafa","family":"Sijilmassi","sequence":"first","affiliation":[{"name":"Optics Department, Faculty of Optics and Optometry, Complutense University of Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"(2024). 2024 Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s Dement., 20, 3708\u20133821.","DOI":"10.1002\/alz.13809"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/jnnp.57.6.672","article-title":"Parkinson\u2019s disease","volume":"57","author":"Marsden","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/14737167.2017.1313118","article-title":"Direct and indirect cost of managing Alzheimer\u2019s disease and related dementias in the United States","volume":"17","author":"Deb","year":"2017","journal-title":"Expert. Rev. Pharmacoecon. Outcomes Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/mds.27579","article-title":"The long-term direct and indirect economic burden among Parkinson\u2019s disease caregivers in the United States","volume":"34","author":"Macaulay","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/bcpt.14003","article-title":"A review on the new age methodologies for early detection of Alzheimer\u2019s and Parkinson\u2019s disease","volume":"134","author":"Ghosh","year":"2024","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"ref_7","first-page":"10","article-title":"Parkinson\u2019s disease: Prevalence, diagnosis and impact","volume":"25","author":"Wong","year":"2014","journal-title":"Health Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1759091414562107","DOI":"10.1177\/1759091414562107","article-title":"Connecting the retina to the brain","volume":"6","author":"Erskine","year":"2014","journal-title":"ASN Neuro"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ptito, M., Bleau, M., and Bouskila, J. (2021). The retina: A window into the brain. Cells, 10.","DOI":"10.3390\/cells10123269"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/08164622.2021.1984179","article-title":"Retinal imaging biomarkers of neurodegenerative diseases","volume":"105","author":"Christinaki","year":"2022","journal-title":"Clin. Exp. Optom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41433-022-02056-9","article-title":"Optical coherence tomography as retinal imaging biomarker of neuroinflammation\/neurodegeneration in systemic disorders in adults and children","volume":"37","author":"Vujosevic","year":"2023","journal-title":"Eye"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ajmg.c.30049","article-title":"Embryology of neural tube development","volume":"135","author":"Sadler","year":"2005","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K.A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., and Aigner, L. (2016). Brain and retinal pericytes: Origin, function and role. Front. Cell. Neurosci., 10.","DOI":"10.3389\/fncel.2016.00020"},{"key":"ref_14","unstructured":"Bales, T.R., Lopez, M.J., and Clark, J. (2023). Embryology, eye. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12151","DOI":"10.1038\/s41598-021-91584-7","article-title":"Comparative transcriptome analysis of inner blood-retinal barrier and blood\u2013brain barrier in rats","volume":"11","author":"Li","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: A rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J. Anat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain\u2014From eye research to CNS disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_18","unstructured":"Dowling, J.E. (1987). The Retina: An Approachable Part of the Brain, Harvard University Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/cne.10652","article-title":"Melanopsin retinal ganglion cells receive bipolar and amacrine cell synapses","volume":"460","author":"Belenky","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tempone, M.H., Borges-Martins, V.P., C\u00e9sar, F., Alexandrino-Mattos, D.P., de Figueiredo, C.S., Raony, \u00cd., Dos Santos, A.A., Duarte-Silva, A.T., Dias, M.S., and Freitas, H.R. (2024). The healthy and diseased retina seen through neuron\u2013glia interactions. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202312.1868.v2"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.medici.2014.10.008","article-title":"A new maximum color contrast sensitivity test for detecting early changes of visual function in age-related macular degeneration","volume":"50","year":"2014","journal-title":"Medicina"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/jnnp-2022-329342","article-title":"Structural and functional changes in the retina in Parkinson\u2019s disease","volume":"94","author":"Alves","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer\u2019s disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb. Cortex"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1212\/01.WNL.0000129697.01779.0A","article-title":"The importance of neuritic plaques and tangles to the development and evolution of AD","volume":"62","author":"Tiraboschi","year":"2004","journal-title":"Neurology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1002\/hbm.24246","article-title":"Thinner retinal layers are associated with changes in the visual pathway: A population-based study","volume":"39","author":"Mutlu","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/S1388-2457(01)00620-4","article-title":"Morphological and functional retinal impairment in Alzheimer\u2019s disease patients","volume":"112","author":"Parisi","year":"2001","journal-title":"Clin. Neurophysiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0197-4580(96)00010-3","article-title":"Retinal pathology in Alzheimer\u2019s disease. I. Ganglion cell loss in foveal\/parafoveal retina","volume":"17","author":"Blanks","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Salobrar-Garc\u00eda, E., de Hoz, R., Ram\u00edrez, A.I., L\u00f3pez-Cuenca, I., Rojas, P., Vazirani, R., Amarante, C., Yubero, R., Gil, P., and Pinazo-Dur\u00e1n, M.D. (2019). Changes in visual function and retinal structure in the progression of Alzheimer\u2019s disease. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220535"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1038\/tp.2012.150","article-title":"Retinal vascular biomarkers for early detection and monitoring of Alzheimer\u2019s disease","volume":"3","author":"Frost","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1167\/iovs.06-1029","article-title":"Retinal abnormalities in early Alzheimer\u2019s disease","volume":"48","author":"Berisha","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13195-020-00715-1","article-title":"Combination of snapshot hyperspectral retinal imaging and optical coherence tomography to identify Alzheimer\u2019s disease patients","volume":"12","author":"Lemmens","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s43586-022-00162-2","article-title":"Optical coherence tomography","volume":"2","author":"Bouma","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41433-020-01288-x","article-title":"Optical coherence tomography (OCT) in neuro-ophthalmology","volume":"35","author":"Minakaran","year":"2021","journal-title":"Eye"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/WNO.0000000000001959","article-title":"Retinal thickness in essential tremor and early Parkinson disease: Exploring diagnostic insights","volume":"44","author":"Terravecchia","year":"2024","journal-title":"J. Neuroophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s40520-022-02211-y","article-title":"Quantitative analysis of related parameters of retinal nerve fiber layer and ganglion cell complex thickness in patients with different degrees of Parkinson\u2019s disease","volume":"34","author":"Zhao","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.parkreldis.2020.11.025","article-title":"Correlations between retinal nerve fiber layer thickness and cognitive progression in Parkinson\u2019s disease: A longitudinal study","volume":"82","author":"Zhang","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10792-021-02133-0","article-title":"Investigation of the pathophysiology of the retina and choroid in Parkinson\u2019s disease by optical coherence tomography","volume":"42","author":"Kamata","year":"2022","journal-title":"Int. Ophthalmol."},{"key":"ref_38","first-page":"167","article-title":"Altered outer retinal structure, electrophysiology and visual perception in Parkinson\u2019s disease","volume":"14","author":"Tran","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.2147\/IJGM.S426501","article-title":"Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson\u2019s Disease","volume":"16","author":"Tu","year":"2023","journal-title":"Int. J. Gen. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40478-025-01936-x","article-title":"Dynamics of retinal changes in early-stage Parkinson\u2019s disease","volume":"13","author":"Bocos","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Elanwar, R., Al Masry, H., Ibrahim, A., Hussein, M., Ibrahim, S., and Masoud, M.M. (2023). Retinal functional and structural changes in patients with Parkinson\u2019s disease. BMC Neurol., 23.","DOI":"10.1186\/s12883-023-03373-6"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ajo.2013.09.028","article-title":"Distribution of retinal layer atrophy in patients with Parkinson disease and association with disease severity and duration","volume":"157","author":"Larrosa","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.18071\/isz.74.0057","article-title":"Retinal morphological changes during the two years of follow-up in parkinson\u2019s disease","volume":"74","author":"Atum","year":"2021","journal-title":"Ideggyogy. Szle."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s10792-023-02653-x","article-title":"Inner retinal layers\u2019 alterations of the microvasculature in early stages of Parkinson\u2019s disease: A cross sectional study","volume":"43","author":"Christou","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1167\/iovs.17-23240","article-title":"Outer retinal assessment using spectral-domain optical coherence tomography in patients with Alzheimer\u2019s and Parkinson\u2019s disease","volume":"59","author":"Uchida","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhao, J., Gu, Y., Chen, B., Guo, J., Xie, J., Yan, Q., Ma, Y., Wu, Y., and Zhang, J. (2021). Outer retinal layer thickness changes in white matter hyperintensity and parkinson\u2019s disease. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.741651"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/acn3.52172","article-title":"Retina as a potential biomarker for the early stage of Alzheimer\u2019s disease spectrum","volume":"11","author":"Gao","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jamaophthalmol.2018.3556","article-title":"Association of preclinical Alzheimer disease with optical coherence tomographic angiography findings","volume":"136","author":"Apte","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13195-022-00982-0","article-title":"A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer\u2019s disease","volume":"14","author":"Chua","year":"2022","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3233\/JAD-210533","article-title":"Association of brain volume and retinal thickness in the early stages of Alzheimer\u2019s disease","volume":"91","author":"Mathew","year":"2023","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaophthalmol.2022.1563","article-title":"Association between retinal layer thickness and cognitive decline in older adults","volume":"140","author":"Kim","year":"2022","journal-title":"JAMA Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"fcab258","DOI":"10.1093\/braincomms\/fcab258","article-title":"Reading cognition from the eyes: Association of retinal nerve fibre layer thickness with cognitive performance in a population-based study","volume":"3","author":"Girbardt","year":"2021","journal-title":"Brain Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e70672","DOI":"10.1002\/alz.70672","article-title":"Retinal biomarkers in cognitive impairment and dementia: Structural, functional, and molecular insights","volume":"21","author":"Min","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100901","DOI":"10.1117\/1.JBO.20.10.100901","article-title":"Methods and algorithms for optical coherence tomography-based angiography: A review and comparison","volume":"20","author":"Zhang","year":"2015","journal-title":"J. Biomed. Opt."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40942-015-0005-8","article-title":"A review of optical coherence tomography angiography (OCTA)","volume":"1","author":"Romano","year":"2015","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/17434440.2024.2419961","article-title":"Vascular changes in optical coherence tomography angiography unveiling the depths of dry age-related macular degeneration: A review","volume":"21","author":"Kijonka","year":"2024","journal-title":"Expert. Rev. Med. Devices"},{"key":"ref_58","first-page":"115","article-title":"Optical coherence tomography angiography and glaucoma: A brief review","volume":"8","author":"Moghimi","year":"2019","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40662-019-0160-3","article-title":"Optical coherence tomography angiography in diabetic retinopathy: A review of current applications","volume":"6","author":"Tey","year":"2019","journal-title":"Eye Vision."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1167\/iovs.17-23230","article-title":"Retinal microvascular impairment in the early stages of Parkinson\u2019s disease","volume":"59","author":"Kwapong","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/IAE.0000000000002641","article-title":"Characterization by fractal dimension analysis of the retinal capillary network in Parkinson disease","volume":"40","author":"Shi","year":"2020","journal-title":"Retina"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Murueta-Goyena, A., Barrenechea, M., Erramuzpe, A., Teijeira-Portas, S., Pengo, M., Ayala, U., Romero-Bascones, D., Acera, M., Del Pino, R., and G\u00f3mez-Esteban, J.C. (2021). Foveal remodeling of retinal microvasculature in Parkinson\u2019s disease. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.708700"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/jrms.jrms_250_24","article-title":"Assessment of retinal blood flow changes in early Parkinson\u2019s disease: An optical coherence tomography angiography study","volume":"30","author":"Eker","year":"2025","journal-title":"J. Res. Med. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Xu, B., Wang, X., Guo, J., Xu, H., Tang, B., Jiao, B., and Shen, L. (2022). Retinal microvascular density was associated with the clinical progression of Parkinson\u2019s disease. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.818597"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3233\/JAD-180738","article-title":"Evaluation of ocular perfusion in Alzheimer\u2019s disease using optical coherence tomography angiography","volume":"66","author":"Lahme","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.oret.2019.02.002","article-title":"Retinal microvascular and neurodegenerative changes in Alzheimer\u2019s disease and mild cognitive impairment compared with control participants","volume":"3","author":"Yoon","year":"2019","journal-title":"Ophthalmol. Retin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1167\/iovs.19-27028","article-title":"Comparison of retinal microvasculature in patients with Alzheimer\u2019s disease and primary open-angle glaucoma by optical coherence tomography angiography","volume":"60","author":"Zabel","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13195-020-00724-0","article-title":"Retinal microvasculature dysfunction is associated with Alzheimer\u2019s disease and mild cognitive impairment","volume":"12","author":"Chua","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1111\/aos.14381","article-title":"Retinal microvascular attenuation in mental cognitive impairment and Alzheimer\u2019s disease by optical coherence tomography angiography","volume":"98","author":"Wu","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1136\/bjo-2022-321399","article-title":"Deep segmentation of OCTA for evaluation and association of changes of retinal microvasculature with Alzheimer\u2019s disease and mild cognitive impairment","volume":"108","author":"Xie","year":"2024","journal-title":"Br. J. Ophthalmol."},{"key":"ref_71","first-page":"2507","article-title":"Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography","volume":"8","author":"Saxena","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.survophthal.2022.07.006","article-title":"Retinal and choroidal changes in AMD: A systematic review and meta-analysis of spectral-domain optical coherence tomography studies","volume":"68","author":"Salehi","year":"2023","journal-title":"Surv. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.3928\/15428877-20101031-19","article-title":"Spectral domain optical coherence tomography imaging of dry age-related macular degeneration","volume":"41","author":"Yehoshua","year":"2010","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s41983-021-00421-1","article-title":"Optical coherence tomography in patients with Parkinson\u2019s disease","volume":"58","author":"Esmat","year":"2022","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/ijo.IJO_1409_21","article-title":"Assessment of retinal manifestations of Parkinson\u2019s disease using spectral domain optical coherence tomography: A study in Indian eyes","volume":"70","author":"Verghese","year":"2022","journal-title":"Indian. J. Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp-2023-331083","article-title":"Visual dysfunction is a better predictor than retinal thickness for dementia in Parkinson\u2019s disease","volume":"94","author":"Hannaway","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107932","DOI":"10.1016\/j.parkreldis.2025.107932","article-title":"Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: An explorative study","volume":"137","author":"Cennamo","year":"2025","journal-title":"Park. Relat. Disord."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Svetel, M., Mari\u0107, G., Bo\u017ei\u0107, M., Lazi\u0107, U., Milovanovi\u0107, A., Jak\u0161i\u0107, J., Petrovi\u0107, I., Dimitrijevi\u0107, A., Kne\u017eevi\u0107, M., and Pekmezovi\u0107, T. (2025). Retinal Thickness in Patients with Parkinson\u2019s Disease and Dopa Responsive Dystonia\u2014Is There Any Difference?. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051227"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ibrahim, Y., Macerollo, A., Sardone, R., Shen, Y., Romano, V., and Zheng, Y. (2025). Retinal microvascular density and inner thickness in Alzheimer\u2019s disease and mild cognitive impairment. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1477008"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s10072-023-07256-z","article-title":"Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer\u2019s disease","volume":"45","author":"Zhang","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wang, R., Cai, J., Gao, Y., Tang, Y., Gao, H., Qin, L., Cai, H., Yang, F., Ren, Y., and Luo, C. (2025). Retinal biomarkers for the risk of Alzheimer\u2019s disease and frontotemporal dementia. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1513302"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Abboud, I., Xu, E., Xu, S., Alhasany, A., Wang, Z., Wu, X., Astraea, N., Jiang, F., Hu, Z.J., and Chan, J.W. (2025). Emerging Oculomic Signatures: Linking Thickness of Entire Retinal Layers with Plasma Biomarkers in Preclinical Alzheimer\u2019s Disease. J. Clin. Med., 15.","DOI":"10.3390\/jcm15010275"},{"key":"ref_83","first-page":"2773","article-title":"Outer Retina Layer Thicknesses as Predictors of Choriocapillaris Impairment in Normal Aging Subjects at Risk for Alzheimer\u2019s Disease","volume":"66","author":"Chan","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-024-01668-5","article-title":"Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer\u2019s disease","volume":"17","author":"Ravichandran","year":"2025","journal-title":"Alzheimer\u2019s Res. Ther."}],"container-title":["Journal of Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2313-433X\/12\/3\/104\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:21:00Z","timestamp":1772209260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2313-433X\/12\/3\/104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":84,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["jimaging12030104"],"URL":"https:\/\/doi.org\/10.3390\/jimaging12030104","relation":{},"ISSN":["2313-433X"],"issn-type":[{"value":"2313-433X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}