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Imaging"],"abstract":"<jats:p>Myocardial scar and edema segmentation from multi-sequence cardiac magnetic resonance (MS-CMR) is important for myocardial infarction assessment, but remains challenging due to heterogeneous modal characteristics, severe class imbalance, and the small, ambiguous nature of pathological regions. To address these issues, a dynamic synergistic segmentation network (DSS-Net) is proposed for myocardial pathology segmentation. The framework adopts a coarse-to-fine strategy, in which a coarse stage first segments the myocardium to provide anatomical priors and region constraints, and a fine stage then delineates scar and edema within the myocardium-aware space. In addition, a Modality Dynamic Fusion Module (MDFM) is designed to adaptively emphasize pathology-relevant modal information, and a Stage Feature Aggregation Module (SFAM) is introduced to enhance cross-stage feature interactions and fine-grained lesion representation. Experiments on the MyoPS 2020 and MyoPS 2024 datasets demonstrate that DSS-Net achieves competitive and balanced performance, reaching Dice scores of 0.706 for scar and 0.753 for edema on MyoPS 2020. Additionally, compared with SOTA methods in the MyoPS 2020 Challenge, the proposed method attains comparable scar segmentation performance while maintaining a more balanced trade-off between sensitivity and specificity. These findings suggest that combining anatomical guidance with pathology-aware multi-modal learning is a promising strategy for robust myocardial pathology segmentation in MS-CMR images.<\/jats:p>","DOI":"10.3390\/jimaging12060269","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:18:43Z","timestamp":1781860723000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two-Stage Dynamic Synergistic Segmentation Method for Myocardial Pathology"],"prefix":"10.3390","volume":"12","author":[{"given":"Dongsheng","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Zhejiang University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-4790","authenticated-orcid":false,"given":"Mingfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"The Executive Group on behalf of the Joint European Society of Cardiology (ESC)\/American College of Cardiology (ACC)\/American Heart Association (AHA)\/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. 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