{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:12:50Z","timestamp":1760235170785,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L014823\/1"],"award-info":[{"award-number":["EP\/L014823\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/18\/12\/33270","SI\/14\/1\/30718"],"award-info":[{"award-number":["FS\/18\/12\/33270","SI\/14\/1\/30718"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Society","award":["IF170011"],"award-info":[{"award-number":["IF170011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>The porcine pancreatic elastase (PPE) model is a common preclinical model of abdominal aortic aneurysms (AAA). Some notable characteristics of this model include the low aortic rupture rate, non-progressive disease course, and infra-renal AAA formation. Enhanced [18F]fluorothymidine ([18F]FLT) uptake on positron emission tomography\/computed tomography (PET\/CT) has previously been reported in the angiotensin II-induced murine model of AAA. Here, we report our preliminary findings of investigating [18F]FLT uptake in the PPE murine model of AAA. [18F]FLT uptake was found to be substantially increased in the abdominal areas recovering from the surgery, whilst it was not found to be significantly increased within the PPE-induced AAA, as confirmed using in vivo PET\/CT and ex vivo whole-organ gamma counting (PPE, n = 7; controls, n = 3). This finding suggests that the [18F]FLT may not be an appropriate radiotracer for this specific AAA model, and further studies with larger sample sizes are warranted to elucidate the pathobiology contributing to the reduced uptake of [18F]FLT in this model.<\/jats:p>","DOI":"10.3390\/jimaging7080130","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T03:57:41Z","timestamp":1628049461000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["[18F]Fluorothymidine Uptake in the Porcine Pancreatic Elastase-Induced Model of Abdominal Aortic Aneurysm"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-9312","authenticated-orcid":false,"given":"Richa","family":"Gandhi","sequence":"first","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Koch-Paszkowski","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-2477","authenticated-orcid":false,"given":"Charalampos","family":"Tsoumpas","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/ATVBAHA.120.315812","article-title":"Imaging Biological Pathways in Abdominal Aortic Aneurysms Using Positron Emission Tomography","volume":"41","author":"Bell","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gandhi, R., Bell, M., Bailey, M., and Tsoumpas, C. (2021). Prospect of Positron Emission Tomography for Abdominal Aortic Aneurysm Risk Stratification. J. Nucl. Cardiol., 1\u201311.","DOI":"10.1007\/s12350-021-02616-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1002\/ctm2.386","article-title":"Radionuclide Molecular Imaging of Abdominal Aortic Aneurysms for Risk Stratification and Non-Invasive Therapy Assessment","volume":"11","author":"Gandhi","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/01.CIR.82.3.973","article-title":"Elastase-Induced Experimental Aneurysms in Rats","volume":"82","author":"Anidjar","year":"1990","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.surg.2012.02.010","article-title":"Development of a Novel Murine Model of Aortic Aneurysms Using Peri-Adventitial Elastase","volume":"152","author":"Bhamidipati","year":"2012","journal-title":"Surgery"},{"key":"ref_6","unstructured":"Gandhi, R., Cawthorne, C., Craggs, L.J.L., Wright, J.D., Domarkas, J., He, P., Koch-Paszkowski, J., Shires, M., Scarsbrook, A.F., and Archibald, S.J. (2019). Cell Proliferation Detected Using [18F]FLT PET\/CT as an Early Marker of Abdominal Aortic Aneurysm. J. Nucl. Cardiol., 1\u201311."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Waduud, M.A., Kandavelu, P., Reay, M., Paradine, K., Scott, D.J.A., and Bailey, M.A. (2021). High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm. Aorta, in press.","DOI":"10.1055\/s-0041-1731404"},{"key":"ref_8","unstructured":"Rasband, W.S. (2021, May 27). U. S. National Institutes of Health, Bethesda, Maryland, USA. Available online: http:\/\/ci.nii.ac.jp\/naid\/20000508795\/en\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/ATVBAHA.116.308534","article-title":"Translational Relevance and Recent Advances of Animal Models of Abdominal Aortic Aneurysm","volume":"37","author":"Caligiuri","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/SLA.0000000000000602","article-title":"Increased 18F-FDG Uptake Is Predictive of Rupture in a Novel Rat Abdominal Aortic Aneurysm Rupture Model","volume":"261","author":"English","year":"2015","journal-title":"Ann. Surg."}],"container-title":["Journal of Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2313-433X\/7\/8\/130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:40:07Z","timestamp":1760164807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2313-433X\/7\/8\/130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jimaging7080130"],"URL":"https:\/\/doi.org\/10.3390\/jimaging7080130","relation":{},"ISSN":["2313-433X"],"issn-type":[{"type":"electronic","value":"2313-433X"}],"subject":[],"published":{"date-parts":[[2021,8,4]]}}}