{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:16:22Z","timestamp":1776827782238,"version":"3.51.2"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation Fund Denmark\u2014InnoExplorer","award":["2054-00019B"],"award-info":[{"award-number":["2054-00019B"]}]},{"name":"Innovation Fund Denmark\u2014InnoExplorer","award":["NNF21SA0069151"],"award-info":[{"award-number":["NNF21SA0069151"]}]},{"name":"Innovation Fund Denmark\u2014InnoExplorer","award":["2022-1276"],"award-info":[{"award-number":["2022-1276"]}]},{"name":"Novo Nordisk Foundation","award":["2054-00019B"],"award-info":[{"award-number":["2054-00019B"]}]},{"name":"Novo Nordisk Foundation","award":["NNF21SA0069151"],"award-info":[{"award-number":["NNF21SA0069151"]}]},{"name":"Novo Nordisk Foundation","award":["2022-1276"],"award-info":[{"award-number":["2022-1276"]}]},{"name":"BetaHealth","award":["2054-00019B"],"award-info":[{"award-number":["2054-00019B"]}]},{"name":"BetaHealth","award":["NNF21SA0069151"],"award-info":[{"award-number":["NNF21SA0069151"]}]},{"name":"BetaHealth","award":["2022-1276"],"award-info":[{"award-number":["2022-1276"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Surgery is the primary treatment for tongue cancer. The goal is a complete resection of the tumor with an adequate margin of healthy tissue around the tumor.Inadequate margins lead to a high risk of local cancer recurrence and the need for adjuvant therapies. Ex vivo imaging of the resected surgical specimen has been suggested for margin assessment and improved surgical results. Therefore, we have developed a novel three-dimensional (3D) ultrasound imaging technique to improve the assessment of resection margins during surgery. In this research protocol, we describe a study comparing the accuracy of 3D ultrasound, magnetic resonance imaging (MRI), and clinical examination of the surgical specimen to assess the resection margins during cancer surgery. Tumor segmentation and margin measurement will be performed using 3D ultrasound and MRI of the ex vivo specimen. We will determine the accuracy of each method by comparing the margin measurements and the proportion of correctly classified margins (positive, close, and free) obtained by each technique with respect to the gold standard histopathology.<\/jats:p>","DOI":"10.3390\/jimaging9090174","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:57:35Z","timestamp":1693205855000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["3D Ultrasound and MRI in Assessing Resection Margins during Tongue Cancer Surgery: A Research Protocol for a Clinical Diagnostic Accuracy Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-7362","authenticated-orcid":false,"given":"Fatemeh","family":"Makouei","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina Klitm\u00f8ller","family":"Agander","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Ewertsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"},{"name":"Department of Radiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten Bo","family":"S\u00f8ndergaard Svendsen","sequence":"additional","affiliation":[{"name":"Copenhagen Academy for Medical Education and Simulation, The Capital Region of Denmark, DK-2100 Copenhagen, Denmark"},{"name":"Department of Computer Science, University of Copenhagen, 2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Norling","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1900-3445","authenticated-orcid":false,"given":"Mikkel","family":"Kaltoft","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-1537","authenticated-orcid":false,"given":"Adam Espe","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"},{"name":"Department of Radiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob H\u00f8ygaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Wessel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Todsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark"},{"name":"Copenhagen Academy for Medical Education and Simulation, The Capital Region of Denmark, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hed.24589","article-title":"Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study","volume":"39","author":"Ng","year":"2016","journal-title":"Head Neck"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1080\/0284186X.2017.1307516","article-title":"Increasing incidence and survival in oral cancer: A nationwide Danish study from 1980 to 2014","volume":"56","author":"Karnov","year":"2017","journal-title":"Acta Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1200\/JCO.2015.61.2929","article-title":"Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions","volume":"33","author":"Chinn","year":"2015","journal-title":"J. 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