{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:37:34Z","timestamp":1791412654740,"version":"4.3.3"},"reference-count":201,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Imaging"],"abstract":"<jats:p>Objective: Positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro- D-glucose integrated with computed tomography (18F-FDG PET\/CT) or magnetic resonance imaging (18F-FDG PET\/MRI) has emerged as a promising tool for managing various types of cancer. This review study was conducted to investigate the role of 18F- FDG PET\/CT and FDG PET\/MRI in the management of gynecological malignancies. Search strategy: We searched for relevant articles in the three databases PubMed\/MEDLINE, Scopus, and Web of Science. Selection criteria: All studies reporting data on the FDG PET\/CT and FDG PET MRI in the management of gynecological cancer, performed anywhere in the world and published exclusively in the English language, were included in the present study. Data collection and analysis: We used the EndNote software (EndNote X8.1, Thomson Reuters) to list the studies and screen them on the basis of the inclusion criteria. Data, including first author, publication year, sample size, clinical application, imaging type, and main result, were extracted and tabulated in Excel. The sensitivity, specificity, and diagnostic accuracy of the modalities were extracted and summarized. Main results: After screening 988 records, 166 studies published between 2004 and 2022 were included, covering various methodologies. Studies were divided into the following five categories: the role of FDG PET\/CT and FDG-PET\/MRI in the management of: (a) endometrial cancer (n = 30); (b) ovarian cancer (n = 60); (c) cervical cancer (n = 50); (d) vulvar and vagina cancers (n = 12); and (e) gynecological cancers (n = 14). Conclusions: FDG PET\/CT and FDG PET\/MRI have demonstrated potential as non-invasive imaging tools for enhancing the management of gynecological malignancies. Nevertheless, certain associated challenges warrant attention.<\/jats:p>","DOI":"10.3390\/jimaging9100223","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:38:42Z","timestamp":1697294322000},"page":"223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["18F-FDG PET\/MRI and 18F-FDG PET\/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-6771","authenticated-orcid":false,"given":"Leila","family":"Allahqoli","sequence":"first","affiliation":[{"name":"Ministry of Health and Medical Education, Tehran 1467664961, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil","family":"Hakimi","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Midwifery, Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz 516615731, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2802","authenticated-orcid":false,"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology, \u201cPaolo Giaccone\u201d Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Momenimovahed","sequence":"additional","affiliation":[{"name":"Department of Midwifery and Reproductive Health, Qom University of Medical Sciences, Qom 3716993456, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrooz","family":"Mazidimoradi","sequence":"additional","affiliation":[{"name":"Neyriz Public Health Clinic, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran 141973317, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Fallahi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj 6617713446, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Salehiniya","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand 9717853076, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Matin","family":"Ghiasvand","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Amirkabir University of Technology (AUT), Tehran 1591634311, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-6034","authenticated-orcid":false,"given":"Ibrahim","family":"Alkatout","sequence":"additional","affiliation":[{"name":"University Hospitals Schleswig-Holstein, Campus Kiel, Kiel School of Gynaecological Endoscopy, Arnold-Heller-Str. 3, Haus 24, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s40944-023-00714-8","article-title":"Temporal Trends of Ovarian Cancer Between 1990 and 2019, in Asian Countries by Geographical Region and SDI, Comparison with Global Data","volume":"21","author":"Momenimovahed","year":"2023","journal-title":"Indian J. 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