{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:17:53Z","timestamp":1793449073481,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Paxman Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMAHP"],"abstract":"<jats:p>Alopecia is an undesirable side effect of cancer chemotherapy. The mitigation of alopecia is a desirable adjunct treatment for patients with cancer. FDA-cleared scalp cooling (SC) devices have been successfully used to prevent or reduce chemotherapy-induced alopecia (CIA). This paper provides an understanding of the implementation and value of the new Insurance-Based Billing Model used in the USA for SC and its benefits compared with the original self-pay model. This improved compensation change will result in all patients in need, including underserved and disadvantaged populations, receiving equitable healthcare by allowing access to this valuable supportive care technology.<\/jats:p>","DOI":"10.3390\/jmahp12030013","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"158-168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Expanding the Availability of Scalp Cooling to All Patients at Risk of Chemotherapy-Induced Alopecia"],"prefix":"10.3390","volume":"12","author":[{"given":"Portia","family":"Lagmay-Fuentes","sequence":"first","affiliation":[{"name":"RWJ Barnabas Health, Hamilton Township, NJ 08690, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Smith","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Krus","sequence":"additional","affiliation":[{"name":"Washington University Siteman Cancer Center, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Lewis","sequence":"additional","affiliation":[{"name":"Washington University Siteman Cancer Center, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Latif","sequence":"additional","affiliation":[{"name":"Oncologist, Sturdy Memorial Hospital, Attelboro, MA 02703, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Gagliardo","sequence":"additional","affiliation":[{"name":"RWJ Barnabas Health, Hamilton Township, NJ 08690, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet","family":"Kohli","sequence":"additional","affiliation":[{"name":"RWJ Barnabas Health, Hamilton Township, NJ 08690, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/pon.1245","article-title":"Chemotherapy-Induced Alopecia and Effects on Quality of Life among Women with Breast Cancer: A Literature Review","volume":"17","author":"Lemieux","year":"2008","journal-title":"Psycho-Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ejon.2013.02.004","article-title":"Impact of Scalp Cooling on Chemotherapy-Induced Alopecia, Wig Use and Hair Growth of Patients with Cancer","volume":"17","author":"Breed","year":"2013","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_3","unstructured":"(2024, May 13). Using Cooling Caps to Reduce Hair Loss|Scalp Hypothermia. Available online: https:\/\/www.cancer.org\/cancer\/managing-cancer\/side-effects\/hair-skin-nails\/hair-loss\/cold-caps.html#:~:text=The%20cold%20also%20decreases%20the."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e390428","DOI":"10.1200\/EDBK_390428","article-title":"Improving Quality of Life during Chemotherapy: Cannabinoids, Cryotherapy, and Scalp Cooling","volume":"43","author":"Michel","year":"2023","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_5","unstructured":"(2024, April 17). FDA Clears Expanded Use of Cooling Cap to Reduce Hair Loss during Chemotherapy, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-clears-expanded-use-cooling-cap-reduce-hair-loss-during-chemotherapy."},{"key":"ref_6","unstructured":"Dangi-Garimella, S. (2024, April 14). Paxman Scalp Cooling System Is FDA Approved for Chemotherapy-Associated Alopecia. Available online: https:\/\/www.ajmc.com\/view\/paxman-scalp-cooling-system-is-fda-approved-for-chemotherapy-associated-alopecia\/1000."},{"key":"ref_7","unstructured":"(2023, September 27). The ASCO Post. Available online: https:\/\/ascopost.com\/News\/58963."},{"key":"ref_8","first-page":"413","article-title":"Scalp Cooling: The Prevention of Chemotherapy-Induced Alopecia","volume":"21","author":"Katz","year":"2017","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_9","first-page":"E442","article-title":"Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis","volume":"136","author":"Shin","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_10","unstructured":"(2023, September 28). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Breast Cancer. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf."},{"key":"ref_11","unstructured":"(2023, September 28). Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/ovarian.pdf."},{"key":"ref_12","unstructured":"(2023, September 27). Scalp Cooling for the Prevention of Chemotherapy-Induced Alopecia (A59533), Available online: https:\/\/www.cms.gov\/medicare-coverage-database\/view\/article.aspx?articleId=59533&ver=2."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Dunnill, C., Ibraheem, K., Peake, M., Ioannou, M., Palmer, M., Smith, A., Collett, A., and Georgopoulos, N.T. (2020). Cooling-Mediated Protection from Chemotherapy Drug-Induced Cytotoxicity in Human Keratinocytes by Inhibition of Cellular Drug Uptake. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240454"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1088\/0967-3334\/28\/8\/006","article-title":"The Relationship between Local Scalp Skin Temperature and Cutaneous Perfusion during Scalp Cooling","volume":"28","author":"Janssen","year":"2007","journal-title":"Physiol. Meas."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/jama.2016.21038","article-title":"Association between Use of a Scalp Cooling Device and Alopecia after Chemotherapy for Breast Cancer","volume":"317","author":"Rugo","year":"2017","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1007\/s00520-012-1465-0","article-title":"Short Post-Infusion Scalp Cooling Time in the Prevention of Docetaxel-Induced Alopecia","volume":"20","author":"Breed","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s00520-013-1804-9","article-title":"Efficacy and Tolerability of Two Scalp Cooling Systems for the Prevention of Alopecia Associated with Docetaxel Treatment","volume":"21","author":"Betticher","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/jama.2016.20939","article-title":"Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer","volume":"317","author":"Nangia","year":"2017","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.breast.2018.04.012","article-title":"Scalp Cooling Successfully Prevents Alopecia in Breast Cancer Patients Undergoing Anthracycline\/Taxane-Based Chemotherapy","volume":"40","author":"Vasconcelos","year":"2018","journal-title":"Breast"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.breast.2019.12.004","article-title":"Randomised Controlled Trial of Scalp Cooling for the Prevention of Chemotherapy Induced Alopecia","volume":"49","author":"Bajpai","year":"2020","journal-title":"Breast"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/tbj.13711","article-title":"Use of Scalp Cooling Device to Prevent Alopecia for Early Breast Cancer Patients Receiving Chemotherapy: A Prospective Study","volume":"26","author":"Giarratano","year":"2019","journal-title":"Breast J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1200\/OP.21.00273","article-title":"Identifying Barriers and Facilitators to Scalp Cooling Therapy through a National Survey of the Awareness, Practice Patterns, and Attitudes of Oncologists","volume":"18","author":"Novice","year":"2022","journal-title":"JCO Oncol. Pract."},{"key":"ref_23","unstructured":"Hernandez, R. (2016, January 6\u201310). Using the Scalp Cooling System Dignicap for the Prevention of Chemotherapy Induced Alopecia. Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX, USA."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3747\/co.23.3200","article-title":"Sensor-Controlled Scalp Cooling to Prevent Chemotherapy-Induced Alopecia in Female Cancer Patients","volume":"23","author":"Fehr","year":"2016","journal-title":"Curr. Oncol."},{"key":"ref_25","unstructured":"Nangia, J. (2023, September 21). Scalp Cooling for Alopecia Prevention (SCALP), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01986140."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kinoshita, T., Nakayama, T., Fukuma, E., Inokuchi, M., Ishiguro, H., Ogo, E., Kikuchi, M., Jinno, H., Yamazaki, N., and Toi, M. (2019). Efficacy of Scalp Cooling in Preventing and Recovering from Chemotherapy-Induced Alopecia in Breast Cancer Patients: The HOPE Study. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00733"},{"key":"ref_27","unstructured":"Dilawari, A., and Medstar Health Research Institute (2023, October 01). Paxman Measuring the Efficacy of Paxman Scalp Cooling to Prevent Chemotherapy Induced Alopecia (CIA) in Black Patients with Stage I\u2013III Breast or Gynecological Cancers, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04626895."},{"key":"ref_28","unstructured":"(2023, September 21). American Medical Association Insurance Coverage for Scalp Cooling (Cold Cap) Therapy. Available online: https:\/\/www.ama-assn.org\/system\/files\/a22-707.pdf."},{"key":"ref_29","unstructured":"(2023, October 12). Billing & Reimbursement\u2014Paxman. Available online: https:\/\/paxmanscalpcooling.com\/access-support\/us-access-and-support\/us-access-reimbursement\/."},{"key":"ref_30","unstructured":"(2023, October 04). System\u2014Paxman. Available online: https:\/\/paxmanscalpcooling.com\/system."},{"key":"ref_31","unstructured":"(2024, March 11). The DigniCap Scalp Cooling System. Available online: https:\/\/dignicap.com\/delta."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40487-020-00120-6","article-title":"Integration of Physician and Nursing Professional Efforts to Deliver Supportive Scalp Cooling Care to Oncology Patients at Risk for Alopecia","volume":"8","author":"Peterson","year":"2020","journal-title":"Oncol. Ther."},{"key":"ref_33","unstructured":"(2023, September 24). The Paxman Guide to Scalp Cooling. Available online: https:\/\/paxmanscalpcooling.com\/."},{"key":"ref_34","unstructured":"Paxman (2022). A Degree of Control, Paxman. Available online: https:\/\/paxmanscalpcooling.com\/access-support\/us-access-and-support\/scalp-cooling-practice\/."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1111\/j.1365-2648.2011.05668.x","article-title":"Efficacy of Penguin Cap as Scalp Cooling System for Prevention of Alopecia in Patients Undergoing Chemotherapy","volume":"67","author":"Kargar","year":"2011","journal-title":"J. Adv. Nurs."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pon.3531","article-title":"Impact of Chemotherapy-Induced Alopecia Distress on Body Image, Psychosocial Well-Being, and Depression in Breast Cancer Patients","volume":"23","author":"Choi","year":"2014","journal-title":"Psycho-Oncology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1523-5394.2001.96007.pp.x","article-title":"Psychological Sequelae and Alopecia among Women with Cancer","volume":"9","author":"McGarvey","year":"2001","journal-title":"Cancer Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1097\/NCC.0000000000000373","article-title":"The Role of Hair Loss in Cancer Identity","volume":"40","author":"Trusson","year":"2017","journal-title":"Cancer Nurs."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1200\/JOP.18.00033","article-title":"Quality of Life Matters: It Is Time to Integrate Scalp Cooling in Routine Clinical Practice","volume":"14","author":"Nangia","year":"2018","journal-title":"J. Oncol. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jaad.2024.02.049","article-title":"The Financial Burden of Scalp Cooling Therapy: A Nonprofit Organization Data Analysis","volume":"91","author":"Novice","year":"2024","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_41","unstructured":"Byrne, D. (2019). Key Considerations for Implementing a Scalp Cooling Program. Oncol. Nurse, 12."},{"key":"ref_42","unstructured":"Kosko, K. (2023, September 24). Hair to Stay: A Resource to Help Eligible Patients Pay for Scalp Cooling. Available online: https:\/\/www.oncnursingnews.com\/view\/hair-to-stay-a-resource-to-help-eligible-patients-pay-for-scalp-cooling."},{"key":"ref_43","unstructured":"(2023, September 24). Welcome to Hair to Stay. Available online: https:\/\/hairtostay.org\/."},{"key":"ref_44","unstructured":"(2023, October 18). Medicare Payment|CMS, Available online: https:\/\/www.cms.gov\/cms-guide-medical-technology-companies-and-other-interested-parties\/payment."},{"key":"ref_45","unstructured":"(2023, September 27). LCD\u2014Scalp Cooling for the Prevention of Chemotherapy-Induced Alopecia (L39573), Available online: https:\/\/www.cms.gov\/medicare-coverage-database\/view\/lcd.aspx?lcdId=39573&ver=3."},{"key":"ref_46","unstructured":"Paxman (2023). Patient Use Details, Paxman. Available online: https:\/\/paxmanscalpcooling.com\/patients\/."},{"key":"ref_47","unstructured":"(2023, October 17). Dignitana Announces Palmetto GBA Approves First Local Coverage Determination for Scalp Cooling Therapy. Available online: https:\/\/dignitana.com\/news\/5DA6AD18CE10F0BC\/."},{"key":"ref_48","unstructured":"(2023, October 17). MarketScreener PAXMAN Announces Palmetto GBA Approves First Local Coverage Determination for Scalp Cooling Therapy\u2014MarketScreener. Available online: https:\/\/www.marketscreener.com\/quote\/stock\/PAXMAN-AB-PUBL-39437163\/news\/PAXMAN-Announces-Palmetto-GBA-Approves-First-Local-Coverage-Determination-for-Scalp-Cooling-Therapy-44971624\/."},{"key":"ref_49","unstructured":"(2023, October 17). The Pros & Cons of the \u201cBuy and Bill\u201d Model of Pharmaceutical Distribution: What\u2019s Appropriate for Your Practice?. Available online: https:\/\/mms.mckesson.com\/resources\/billing-reimbursement\/the-pros-cons-of-the-buy-and-bill-model-of-pharmaceutical-distribution."},{"key":"ref_50","unstructured":"DeMarzo, A. (2023, September 27). What Is Buy and Bill?. Available online: https:\/\/www.priorauthtraining.org\/what-is-buy-and-bill\/."},{"key":"ref_51","unstructured":"Werble, C. (2017). Medicare Part B. Health Aff."},{"key":"ref_52","unstructured":"Rudowitz, R., Burns, A., Hinton, E., and Mohamed, M. (2023, October 17). 10 Things to Know about Medicaid. Available online: https:\/\/www.kff.org\/mental-health\/issue-brief\/10-things-to-know-about-medicaid\/."}],"container-title":["Journal of Market Access &amp; Health Policy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2001-6689\/12\/3\/13\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:12:31Z","timestamp":1760109151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2001-6689\/12\/3\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jmahp12030013"],"URL":"https:\/\/doi.org\/10.3390\/jmahp12030013","relation":{},"ISSN":["2001-6689"],"issn-type":[{"value":"2001-6689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]}}}