{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:18:39Z","timestamp":1791238719810,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oticon Medical AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mark. Access Health Policy","JMAHP"],"abstract":"<jats:p>Bone conduction hearing implant systems (BCHIs) are established treatments for patients with conductive or mixed hearing loss or single-sided deafness when conventional hearing aids are unsuitable. This study evaluated the cost-effectiveness of the active transcutaneous system Sentio versus a similar system, i.e., Osia in an Australian setting. Scenario analyses also compared Sentio to other systems, i.e., Ponto and Baha Attract. A Markov cohort model was adapted from a previously published source to reflect Australian practice, incorporating device acquisition, surgery, maintenance, battery replacement and adverse event management over a 15-year horizon from a healthcare perspective. Effectiveness inputs were derived from published evidence using a na\u00efve indirect comparison. Extensive sensitivity analyses and external validation tested robustness. In the base case, Sentio was associated with lower costs and a small modelled incremental quality-adjusted life years (QALYs) gain versus Osia. Scenario analyses confirmed cost-effectiveness relative to Ponto and Baha Attract, with outcomes below the Australian willingness-to-pay threshold. Health state utility, device price and reimplantation assumptions were the most influential drivers, yet Sentio remained cost-effective in over 95% of simulations. These findings support Sentio as a clinically and economically efficient BCHI in Australia and highlight the need for direct utility and long-term durability data.<\/jats:p>","DOI":"10.3390\/jmahp14010008","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:05:27Z","timestamp":1769504727000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Cost-Effectiveness Analysis of the Sentio Bone Conduction Hearing Implant System in the Australian Healthcare Setting"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9907-6243","authenticated-orcid":false,"given":"Magnus","family":"V\u00e4rendh","sequence":"first","affiliation":[{"name":"IHE\u2014The Swedish Institute for Health Economics, 223 61 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9649-4887","authenticated-orcid":false,"given":"Ida","family":"Haggren","sequence":"additional","affiliation":[{"name":"IHE\u2014The Swedish Institute for Health Economics, 223 61 Lund, Sweden"},{"name":"Department of Economics, Lund University, 220 07 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-6595","authenticated-orcid":false,"given":"Hel\u00e9n","family":"Lagerkvist","sequence":"additional","affiliation":[{"name":"Oticon Medical AB, 436 32 Askim, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-8978","authenticated-orcid":false,"given":"Maria","family":"\u00c5berg H\u00e5kansson","sequence":"additional","affiliation":[{"name":"Oticon Medical AB, 436 32 Askim, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Hjelmgren","sequence":"additional","affiliation":[{"name":"IHE\u2014The Swedish Institute for Health Economics, 223 61 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref_1","first-page":"79","article-title":"New developments in bone-conduction hearing implants: A review","volume":"8","author":"Reinfeldt","year":"2015","journal-title":"Med. Devices"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/0003489405114S1201","article-title":"Consensus statements on the BAHA system: Where do we stand at present?","volume":"195","author":"Snik","year":"2005","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/MAO.0b013e31829ce7d2","article-title":"Acoustic hearing implants for mixed hearing loss: A systematic review","volume":"34","author":"Verhaert","year":"2013","journal-title":"Otol. Neurotol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/coa.13556","article-title":"Ten years of experience with the Ponto bone-anchored hearing system\u2014A systematic literature review","volume":"45","author":"Lagerkvist","year":"2020","journal-title":"Clin. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/MAO.0b013e318241c0bf","article-title":"Assessment of more than 1,000 implanted percutaneous bone conduction devices: Skin reactions and implant survival","volume":"33","author":"Dun","year":"2012","journal-title":"Otol. Neurotol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1002\/lary.32159","article-title":"Outcomes Following Cochlear Osia 2 Implantation in Patients Ages 5-11 Years: A Multi-Center Trial","volume":"135","author":"Stevens","year":"2025","journal-title":"Laryngoscope"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/MAO.0000000000003159","article-title":"Long-Term, Multicenter Results with the First Transcutaneous Bone Conduction Implant","volume":"42","author":"Sprinzl","year":"2021","journal-title":"Otol. Neurotol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1097\/MAO.0000000000004453","article-title":"Active Osseointegrated Steady-State Implant System: Surgical and Clinical Performance","volume":"46","author":"Caraballo","year":"2025","journal-title":"Otol. Neurotol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/MAO.0000000000004706","article-title":"A Prospective, Multicenter Clinical Investigation on the Safety and Performance of a New Active Transcutaneous Bone-Anchored Implant System","volume":"47","author":"Hol","year":"2025","journal-title":"Otol. Neurotol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00405-022-07715-x","article-title":"A comparative study of audiological outcomes and compliance between the Osia system and other bone conduction hearing implants","volume":"280","author":"Kim","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_11","unstructured":"Lagerkvist, H., and Johansson, M.L. (2024). Whitepaper: The Sentio System\u2014Almost Nothing to See, so Much to Experience, Oticon Medical AB."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00405-021-07068-x","article-title":"Two Bonebridge bone conduction hearing implant generations: Audiological benefit and quality of hearing in children","volume":"279","author":"Sikolova","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e70010","DOI":"10.1002\/lio2.70010","article-title":"A MAUDE database analysis on the new generation of active bone conduction hearing implants","volume":"9","author":"Lein","year":"2024","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/ohn.728","article-title":"Early Results with the New Active Bone-Conduction Hearing Implant: A Systematic Review and Meta-Analysis","volume":"170","author":"Lein","year":"2024","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1177\/00034894241283269","article-title":"A Systematic Review of Surgical Characteristics and Adverse Events of an Active, Transcutaneous Bone Conduction Device","volume":"133","author":"Jukic","year":"2024","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Magele, A., Schoerg, P., Stanek, B., Gradl, B., and Sprinzl, G.M. (2019). Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221484"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/lary.31053","article-title":"Systematic Review and Meta-Analysis of a New Active Transcutaneous Bone Conduction Implant","volume":"134","author":"Key","year":"2024","journal-title":"Laryngoscope"},{"key":"ref_18","unstructured":"Hearing Australia (2025, October 07). Reflecting on a Year of Impact and Commitment to Hearing Health. Available online: https:\/\/www.hearing.com.au\/news-and-articles\/reflecting-on-a-year-of-impact-and-commitment-to-hearing-health\/."},{"key":"ref_19","unstructured":"Deloitte Access Economics (2025, February 04). The Social and Economic Cost of Hearing Loss in Australia. Available online: https:\/\/hcia.com.au\/wp-content\/uploads\/2024\/01\/Social-and-Economic-Cost-of-Hearing-Health-in-Australia_June-2017.pdf."},{"key":"ref_20","unstructured":"Department of Health Disability and Ageing (2025, February 04). Prescribed List of Medical Devices and Human Tissue Products Guide\u2014Draft, Available online: https:\/\/www.health.gov.au\/resources\/publications\/prescribed-list-of-medical-devices-and-human-tissue-products-guide-draft."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/jmahp12010003","article-title":"Comparative Clinical Effectiveness and Cost-Effectiveness of the Cochlear Osia System and Baha Attract System in Patients with Conductive or Mixed Hearing Loss or Single-Sided Deafness","volume":"12","author":"Brunner","year":"2024","journal-title":"J. Mark. Access Health Policy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0272989X12454577","article-title":"ISPOR-SMDM Modeling Good Research Practices Task Force. Modeling good research practices\u2014Overview: A report of the ISPOR-SMDM Modeling Good Research Practices Task Force-1","volume":"32","author":"Caro","year":"2012","journal-title":"Med. Decis. Mak."},{"key":"ref_23","unstructured":"Australian Government DoH, Disability and Ageing (2021). Guidelines for Preparing Assessments for MSAC, Medical Services Advisory Committee."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1007\/s00405-025-09502-w","article-title":"Safety profiles of bone-conduction hearing implants revisited: A meta-analytic comparison adjusted for follow-up time","volume":"282","author":"Caversaccio","year":"2025","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"108503","DOI":"10.1016\/j.heares.2022.108503","article-title":"Long-term follow-up and review of the Bone Conduction Implant","volume":"421","author":"Reinfeldt","year":"2022","journal-title":"Hear. Res."},{"key":"ref_26","unstructured":"Department of Health and Aged Care (2025, February 04). Medicare Benefits Schedule (MBS), Available online: https:\/\/www.mbsonline.gov.au\/internet\/mbsonline\/publishing.nsf\/Content\/Downloads-250101."},{"key":"ref_27","unstructured":"Independent Health and Aged Care Pricing Authority (IHACPA) (2025, February 04). NHCDC Public Sector Cost Weights AR-DRG Version 11.0 2020-21, Available online: https:\/\/www.ihacpa.gov.au\/resources\/national-hospital-cost-data-collection-nhcdc-public-sector-report-2020-21."},{"key":"ref_28","unstructured":"Australian Bureau of Statistics (ABS) (2025, October 10). Medical Products, Appliances and Equipment; Australia, TABLE 7. CPI: Group, Sub-Group and Expenditure Class, Weighted Average of Eight Capital Cities, Available online: https:\/\/www.abs.gov.au\/statistics\/economy\/price-indexes-and-inflation\/consumer-price-index-australia\/sep-quarter-2024#data-downloads."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/MAO.0000000000003590","article-title":"Clinical Performance, Safety, and Patient-Reported Outcomes of an Active Osseointegrated Steady-State Implant System","volume":"43","author":"Briggs","year":"2022","journal-title":"Otol. Neurotol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1007\/s00405-021-07167-9","article-title":"Long-term data of the new transcutaneous partially implantable bone conduction hearing system Osia(R)","volume":"279","author":"Rauch","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ohn.791","article-title":"Clinical Outcomes of an Active, Transcutaneous, Bone Conduction Hearing Device: A Retrospective Study","volume":"171","author":"Jukic","year":"2024","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cruz, L.D.S., Danieli, F., Hakansson, M.A., Johansson, M.L., Dos Santos, F.R., Mirandola Barbosa Reis, A.C., and Hyppolito, M.A. (2023). Minimally invasive surgery as a new clinical standard for bone anchored hearing implants-real-world data from 10 years of follow-up and 228 surgeries. Front. Surg., 10.","DOI":"10.3389\/fsurg.2023.1209927"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Dimitriadis, P.A., Farr, M.R., Allam, A., and Ray, J. (2016). Three year experience with the cochlear BAHA attract implant: A systematic review of the literature. BMC Ear Nose Throat Disord., 16.","DOI":"10.1186\/s12901-016-0033-5"},{"key":"ref_34","unstructured":"(2025, February 05). Hearing Aid Batteries Express. Zenipower 675. Available online: https:\/\/www.hearingaidbatteries.com.au\/zenipower-675-60-cells.html."},{"key":"ref_35","unstructured":"(2025, February 05). Hearing Aid Batteries Express. Zenipower 312. Available online: https:\/\/www.hearingaidbatteries.com.au\/zenipower-312-60-cells.html."},{"key":"ref_36","unstructured":"Department of Health and Aged Care (2025, February 04). Prescribed List of Medical Devices and Human Tissue Products, Available online: https:\/\/www.health.gov.au\/resources\/publications\/prescribed-list-of-medical-devices-and-human-tissue-products?language=en."},{"key":"ref_37","unstructured":"(2025, October 10). Oticon Medical Sentio 1 Mini\u2014Product Information. Available online: https:\/\/sentio.oticonmedical.com\/."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00405-023-08133-3","article-title":"Clinical performance, safety, and patient-reported outcomes of an active osseointegrated bone-conduction hearing implant system at 24-month follow-up","volume":"281","author":"Cowan","year":"2024","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_39","unstructured":"(2025, October 10). Oticon Medical Ponto 5 Superpower\u2014Product Information. Available online: https:\/\/www.oticonmedical.com\/solutions\/bone-conduction\/ponto-5."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/MAO.0000000000004315","article-title":"Evaluation of Clinical Performance of Ponto Implantation Using a Minimally Invasive Surgical Technique\u2014A Prospective Multicenter Study","volume":"45","author":"Teunissen","year":"2024","journal-title":"Otol. Neurotol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/coa.13248","article-title":"Audiological and clinical outcomes of a transcutaneous bone conduction hearing implant: Six-month results from a multicentre study","volume":"44","author":"Monksfield","year":"2019","journal-title":"Clin. Otolaryngol."},{"key":"ref_42","unstructured":"(2025, October 10). Cochlear Limited Datasheet Cochlear Baha 5 Power. Available online: https:\/\/cdn.hjm.aws.inera.se\/83c26cb5-f5f2-4d28-8bdf-cc71b516e64a\/8edf402c-6172-44ae-abee-98ba8816b098\/Baha%205%20Power%20datasheet.pdf."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/AUD.0b013e3181fc98bd","article-title":"Five-year incidence and progression of hearing impairment in an older population","volume":"32","author":"Mitchell","year":"2011","journal-title":"Ear Hear."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00405-023-08099-2","article-title":"Post-implantation clinical cost analysis between transcutaneous and percutaneous bone conduction devices","volume":"281","author":"Aukema","year":"2024","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1097\/MAO.0000000000004111","article-title":"Comparison of Quality of Life Outcomes for Percutaneous Versus Transcutaneous Implantable Hearing Devices: A Systematic Review and Meta-analysis","volume":"45","author":"Gutierrez","year":"2024","journal-title":"Otol. Neurotol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10198-019-01036-3","article-title":"Health state utilities associated with post-surgical Staphylococcus aureus infections","volume":"20","author":"Matza","year":"2019","journal-title":"Eur. J. Health Econ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1477-7525-9-96","article-title":"Deriving health state utilities for the numerical pain rating scale","volume":"9","author":"Dixon","year":"2011","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s42506-024-00159-7","article-title":"Framework for developing cost-effectiveness analysis threshold: The case of Egypt","volume":"99","author":"Fasseeh","year":"2024","journal-title":"J. Egypt. Public Health Assoc."},{"key":"ref_49","unstructured":"CREST (2025, October 25). Step by Step Guide to Economic Evaluation in Cancer Trials. Available online: https:\/\/www.uts.edu.au\/globalassets\/sites\/default\/files\/2024-07\/crest-factsheet_steps-in-an-economic-evaluation_june2024.pdf."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/MAO.0000000000002689","article-title":"Results of a 2-Year Prospective Multicenter Study Evaluating Long-term Audiological and Clinical Outcomes of a Transcutaneous Implant for Bone Conduction Hearing","volume":"41","author":"Kruyt","year":"2020","journal-title":"Otol. Neurotol."}],"container-title":["Journal of Market Access &amp; Health Policy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2001-6689\/14\/1\/8\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:11:50Z","timestamp":1790763110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2001-6689\/14\/1\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["jmahp14010008"],"URL":"https:\/\/doi.org\/10.3390\/jmahp14010008","relation":{},"ISSN":["2001-6689"],"issn-type":[{"value":"2001-6689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}