{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:20Z","timestamp":1791644900100,"version":"4.3.4"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro de Investigaciones\u2014CIN, Universidad Esp\u00edritu Santo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The incidence of candidemia in healthcare centers is associated with high morbidity and mortality. Frequency varies significantly among regions, with some species being more prevalent than others in Latin America. In this study, 191 clinical Candida isolates were collected from a major hospital in Ecuador from January 2019 to February 2020 aiming to assess their prevalence and distribution. After data processing, 168 isolates characterized by the VITEK 2 system were subsequently identified by ITS sequencing. Results showed diverse Candida species distributions, with C. albicans and C. tropicalis being the most prevalent across different clinical sources. In hospitalized individuals, C. tropicalis (38%) and C. albicans (37%) were the most prevalent, followed by, C. parapsilosis (16%), C. glabrata (5%), and other non-Candida albicans (NCA) species (6%). Conversely, C. parapsilosis (48%), C. albicans (20%), and C. glabrata (14%), associated with candidemia, were the most common in blood and CSF. Additionally, uncommon NCA species such as C. haemulonii, C. kefyr, and C. pelliculosa were identified in Ecuador for the first time. Discrepancies in species identification were observed between the VITEK 2 system and ITS sequencing, coinciding at 85%. This highlights the need for ongoing surveillance and identification efforts in Ecuador\u2019s clinical and epidemiological settings.<\/jats:p>","DOI":"10.3390\/jof10050304","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:56:31Z","timestamp":1713930991000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and Species Distribution of Candida Clinical Isolates in a Tertiary Care Hospital in Ecuador Tested from January 2019 to February 2020"],"prefix":"10.3390","volume":"10","author":[{"given":"Yessenia","family":"Acosta-Mosquera","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidad Nacional del Nordeste, Corrientes 3400, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1763-455X","authenticated-orcid":false,"given":"Juan Carlos","family":"Tapia","sequence":"additional","affiliation":[{"name":"Omics Science Laboratory, Faculty of Health Science, Universidad Esp\u00edritu Santo, Samborondon 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-3572","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Armas-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto Interamericano de Cooperaci\u00f3n para la Agricultura (IICA), Representaci\u00f3n Ecuador-Proyecto-5CN-1RBT, Quito 170518, Ecuador"},{"name":"Faculty of Health Science, Universidad Esp\u00edritu Santo, Samborondon 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"C\u00e1ceres-Valdiviezo","sequence":"additional","affiliation":[{"name":"Omics Science Laboratory, Faculty of Health Science, Universidad Esp\u00edritu Santo, Samborondon 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0398-8371","authenticated-orcid":false,"given":"Juan Carlos","family":"Fern\u00e1ndez-Cadena","sequence":"additional","affiliation":[{"name":"African Genome Center, University Mohammed VI Polytechnic (UM6P), Lot 660, Hay Moulay Rachid, Ben Guerir 43150, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2651-5884","authenticated-orcid":false,"given":"Derly","family":"Andrade-Molina","sequence":"additional","affiliation":[{"name":"Omics Science Laboratory, Faculty of Health Science, Universidad Esp\u00edritu Santo, Samborondon 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden Killers: Human Fungal Infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. 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