{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:47Z","timestamp":1760144567532,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"],"award-info":[{"award-number":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"]}]},{"DOI":"10.13039\/501100003593","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia and Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"],"award-info":[{"award-number":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","award":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"],"award-info":[{"award-number":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidade Federal do Mato Grosso do Sul","award":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"],"award-info":[{"award-number":["001","312910\/2020\u20137","422757\/2021-7","71\/000.478\/2021","71\/038.790\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Blood count is crucial for assessing bone marrow\u2019s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (standard deviation SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%), which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes\u2019 role in PCM\u2019s immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters.<\/jats:p>","DOI":"10.3390\/jof10050317","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T10:33:36Z","timestamp":1714386816000},"page":"317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis"],"prefix":"10.3390","volume":"10","author":[{"given":"Eliana da Costa Alvarenga de","family":"Brito","sequence":"first","affiliation":[{"name":"Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana de Oliveira","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Valadares","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Scientific Initiation CNPq, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Lopes Teodoro","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Scientific Initiation CNPq, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Alves","family":"Rezende","sequence":"additional","affiliation":[{"name":"Scientific Initiation CNPq, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Casella","family":"Amorim","sequence":"additional","affiliation":[{"name":"Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzane Eberhart Ribeiro da","family":"Silva","sequence":"additional","affiliation":[{"name":"Scientific Initiation CNPq, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-5917","authenticated-orcid":false,"given":"Rinaldo Poncio","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Tropical Diseases, Botucatu Medical School, S\u00e3o Paulo State University, Botucatu 18618-687, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Schneider","family":"Weber","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamaria Mello Miranda","family":"Paniago","sequence":"additional","affiliation":[{"name":"Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2174\/1874285801711010224","article-title":"Paracoccidioidomycosis: Current Perspectives from Brazil","volume":"11","author":"Mendes","year":"2017","journal-title":"Open Microbiol. 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