{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:08:41Z","timestamp":1776082121705,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FOCANLIS 2019 NRU 1940"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Coccidiomycosis is a potentially life-threatening fungal infection endemic to certain regions of Argentina. The infection is caused by Coccidioides spp. and is primarily diagnosed by Coccidioides antibody (Ab) detection. Access to rapid, highly accurate diagnostic testing is critical to ensure prompt antifungal therapy. The s\u014dna Coccidioides Ab Lateral Flow Assay (LFA) performs faster and requires less laboratory infrastructure and equipment compared with other Ab detection assays, potentially providing a substantial improvement for rapid case screening in coccidioidomycosis-endemic regions; however, validation of this test is needed. Thus, we aimed to evaluate the analytical performance of the s\u014dna Coccidioides Ab (LFA) and compare agreement with anti-Coccidioides Ab detection assays. A total of 103 human sera specimens were tested, including 25 specimens from patients with coccidioidomycosis and 78 from patients without coccidioidomycosis. The s\u014dna Coccidioides Ab Lateral Flow Assay (LFA) was performed with a sensitivity of 88%, and specificity and accuracy of 87%. Furthermore, the Coccidioides Ab LFA had good agreement with other anti-Coccidioides Ab detection assays. Our findings suggest the s\u014dna Coccidioides Ab LFA has satisfactory performance and may be useful for diagnosing coccidioidomycosis in endemic regions.<\/jats:p>","DOI":"10.3390\/jof10050322","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T10:33:36Z","timestamp":1714386816000},"page":"322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Analytical Performance of a Lateral Flow Assay for the Detection of Anti-Coccidioides Antibodies in Human Sera\u2014Argentina"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-0561","authenticated-orcid":false,"given":"Mariana N.","family":"Viale","sequence":"first","affiliation":[{"name":"Laboratorio Nacional de Referencia en Micolog\u00eda Cl\u00ednica, Departamento Micolog\u00eda, Instituto Nacional de Enfermedades Infecciosas (INEI), Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-9809","authenticated-orcid":false,"given":"Diego H.","family":"Caceres","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology Radboudumc\/CWZ, 6525GA Nijmegen, The Netherlands"},{"name":"Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota 111221, Colombia"},{"name":"Immuno-Mycologics Inc. (IMMY), Norman, OK 73069, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Mansilla","sequence":"additional","affiliation":[{"name":"Hospital Interzonal San Juan Bautista, San Fernando del Valle de Catamarca 4700, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Lopez-Joffre","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Referencia en Micolog\u00eda Cl\u00ednica, Departamento Micolog\u00eda, Instituto Nacional de Enfermedades Infecciosas (INEI), Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia G.","family":"Vivot","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Referencia en Micolog\u00eda Cl\u00ednica, Departamento Micolog\u00eda, Instituto Nacional de Enfermedades Infecciosas (INEI), Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"Motter","sequence":"additional","affiliation":[{"name":"Unidad Operativa Centro de Contenci\u00f3n Biol\u00f3gica, Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana I.","family":"Toranzo","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Referencia en Micolog\u00eda Cl\u00ednica, Departamento Micolog\u00eda, Instituto Nacional de Enfermedades Infecciosas (INEI), Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-9340","authenticated-orcid":false,"given":"Cristina E.","family":"Canteros","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Referencia en Micolog\u00eda Cl\u00ednica, Departamento Micolog\u00eda, Instituto Nacional de Enfermedades Infecciosas (INEI), Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud (ANLIS) \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires 1282, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Williams, S.L., and Chiller, T. (2022). Update on the Epidemiology, Diagnosis, and Treatment of Coccidioidomycosis. J. Fungi, 8.","DOI":"10.3390\/jof8070666"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.idc.2021.03.010","article-title":"Coccidioidomycosis","volume":"35","author":"Bays","year":"2021","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lockhart, S.R., Toda, M., Benedict, K., Caceres, D.H., and Litvintseva, A.P. (2021). Endemic and Other Dimorphic Mycoses in The Americas. J. 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