{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:13:53Z","timestamp":1783530833371,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at Cayenne Hospital Center between 2008 and 2022. (3) Results: Our cohort was composed of 31 (91%) adults (&gt;18 years of age) and 3 (9%) children, with a sex ratio, M:F, of 1:2. The median age was higher among the women than among the men (70 versus 54 years). The collection of respiratory samples constituted the majority of the performed examinations (38%). Fever (&gt;37 \u00b0C) was found in 56% of patients. Surprisingly, the histoplasmosis was disseminated in 82% of patients with an overall case fatality rate of 14.7%. However, immunosuppressive conditions were found in 52% (16\/31) of the adult patients, including lymphoid hemopathies, diabetes and immunosuppressive drugs. Conclusions: This disease, though rare and usually considered a mostly benign disease in non-HIV patients, presented a relatively high mortality rate in our cohort. Thus, histoplasmosis should be suspected, screened and investigated as a first line of defense in highly endemic areas, even in immunocompetent and non-HIV patients, especially those with fever or chronic respiratory symptoms.<\/jats:p>","DOI":"10.3390\/jof10060400","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T05:58:00Z","timestamp":1717394280000},"page":"400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histoplasmosis in Non-HIV Infected Patients: Another Neglected Infection in French Guiana"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-6129","authenticated-orcid":false,"given":"Houari","family":"Aissaoui","sequence":"first","affiliation":[{"name":"Department of Medicine, Pneumology and Gastroenterology Units, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Bourne-Watrin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Maladies Infectieuses Tropicales (UMIT), Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Lemarie","sequence":"additional","affiliation":[{"name":"Pneumology Department, Cochin University Hospital AP-HP, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pneumology and Gastroenterology Units, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-2587","authenticated-orcid":false,"given":"Alolia","family":"Aboikoni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pneumology and Gastroenterology Units, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piseth","family":"Chhorn","sequence":"additional","affiliation":[{"name":"Guingamp Hospital Center, F-22200 Pabu, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Gaudard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pneumology and Gastroenterology Units, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazi","family":"Hadj-Amara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Manasse","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamado","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Orthopidic Surgery and Neurosurgery, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-0821","authenticated-orcid":false,"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Epelboin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Maladies Infectieuses Tropicales (UMIT), Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[{"name":"Intensif Care Unit, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-4981","authenticated-orcid":false,"given":"Antoine","family":"Adenis","sequence":"additional","affiliation":[{"name":"Amazin PopHealth, Departement of Research and Innovation in Public Health (DRISP), Clinical Investigation Center (CIC Inserm 1424), Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-3204","authenticated-orcid":false,"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[{"name":"Amazin PopHealth, Departement of Research and Innovation in Public Health (DRISP), Clinical Investigation Center (CIC Inserm 1424), Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-2627","authenticated-orcid":false,"given":"Kinan","family":"Drak Alsibai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cayenne Hospital Center, Cayenne F-97300, French Guiana"},{"name":"Amazin PopHealth, Departement of Research and Innovation in Public Health (DRISP), Clinical Investigation Center (CIC Inserm 1424), Cayenne Hospital Center, Cayenne F-97300, French Guiana"},{"name":"Center of Biological Resources (CRB Amazonie), Cayenne Hospital Center, Cayenne F-97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Louvel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pneumology and Gastroenterology Units, Cayenne Hospital Center, Cayenne F-97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00027-06","article-title":"Kauffman Histoplasmosis: A Clinical and Laboratory Update","volume":"20","author":"Carol","year":"2007","journal-title":"Clin. 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