{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:12:47Z","timestamp":1790802767496,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher Education Personnel\u2014Brazil (CAPES)","award":["88887.890668\/2023-00"],"award-info":[{"award-number":["88887.890668\/2023-00"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel\u2014Brazil (CAPES)","award":["CNPq 310265\/2022-3"],"award-info":[{"award-number":["CNPq 310265\/2022-3"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel\u2014Brazil (CAPES)","award":["N62909-20-1-2034"],"award-info":[{"award-number":["N62909-20-1-2034"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["88887.890668\/2023-00"],"award-info":[{"award-number":["88887.890668\/2023-00"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["CNPq 310265\/2022-3"],"award-info":[{"award-number":["CNPq 310265\/2022-3"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["N62909-20-1-2034"],"award-info":[{"award-number":["N62909-20-1-2034"]}]},{"DOI":"10.13039\/100007297","name":"office of Naval Research Global","doi-asserted-by":"publisher","award":["88887.890668\/2023-00"],"award-info":[{"award-number":["88887.890668\/2023-00"]}],"id":[{"id":"10.13039\/100007297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007297","name":"office of Naval Research Global","doi-asserted-by":"publisher","award":["CNPq 310265\/2022-3"],"award-info":[{"award-number":["CNPq 310265\/2022-3"]}],"id":[{"id":"10.13039\/100007297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007297","name":"office of Naval Research Global","doi-asserted-by":"publisher","award":["N62909-20-1-2034"],"award-info":[{"award-number":["N62909-20-1-2034"]}],"id":[{"id":"10.13039\/100007297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida auris is an emerging Candida sp. that has rapidly spread all over the world. The evidence regarding its origin and emerging resistance is still unclear. The severe infection caused by this species results in significant mortality and morbidity among the elderly and immunocompromised individuals. The development of drug resistance is the major factor associated with the therapeutic failure of existing antifungal agents. Previous studies have addressed the antifungal resistance profile and drug discovery for C. auris. However, complete coverage of this information in a single investigation is not yet available. In this review, we have mainly focused on recent developments in therapeutic strategies against C. auris. Based on the available information, several different approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, synthetic chemicals, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Therefore, we anticipate that the findings gathered in this review will encourage further in vivo studies and clinical trials.<\/jats:p>","DOI":"10.3390\/jof10060408","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:40:26Z","timestamp":1717656026000},"page":"408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris"],"prefix":"10.3390","volume":"10","author":[{"given":"Arumugam","family":"Ganeshkumar","sequence":"first","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"},{"name":"Department of Materials Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMTS), Chennai 602105, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manickam","family":"Muthuselvam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-0005","authenticated-orcid":false,"given":"Patricia Michelle Nagai de","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-1677","authenticated-orcid":false,"given":"Rajendren","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of Marine Science, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-6856","authenticated-orcid":false,"given":"Juliana Campos","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive Candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. 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