{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:38:31Z","timestamp":1779129511539,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The incidence and distribution of coccidioidomycosis are increasing. Information scarcity is evident in Mexico, particularly in non-endemic zones and specific populations. We compared the treatment and outcomes for patients with isolated pulmonary infections and those with disseminated coccidioidomycosis, including mortality rates within six weeks of diagnosis. Of 31 CM cases, 71% were male and 55% were disseminated. For 42% of patients, there was no evidence of having lived in or visited an endemic region. All patients had at least one comorbidity, and 58% had pharmacologic immunosuppressants. The general mortality rate was 30%; without differences between disseminated and localized disease. In our research, we describe a CM with a high frequency of disseminated disease without specific risk factors and non-significant mortality. Exposure to endemic regions was not found in a considerable number of subjects. We consider diverse reasons for why this may be, such as climate change or migration.<\/jats:p>","DOI":"10.3390\/jof10060429","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:11:28Z","timestamp":1718709088000},"page":"429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coccidioidomycosis in Immunocompromised at a Non-Endemic Referral Center in Mexico"],"prefix":"10.3390","volume":"10","author":[{"given":"Carla M.","family":"Rom\u00e1n-Montes","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"},{"name":"Clinical Microbiology Laboratory, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisset","family":"Seoane-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommel","family":"Flores-Miranda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Carolina","family":"Tello-Mercado","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rangel-Cordero","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-1792","authenticated-orcid":false,"given":"Rosa Areli","family":"Mart\u00ednez-Gamboa","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[{"name":"General Direction, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Ponce-de-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-3442","authenticated-orcid":false,"given":"Fernanda","family":"Gonz\u00e1lez-Lara","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"},{"name":"Clinical Microbiology Laboratory, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.idc.2021.03.010","article-title":"Coccidioidomycosis","volume":"35","author":"Bays","year":"2021","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40121-022-00606-y","article-title":"Coccidioidomycosis: A Contemporary Review","volume":"11","author":"Crum","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Boro, R., Iyer, P.C., and Walczak, M.A. (2022). Current Landscape of Coccidioidomycosis. J. Fungi, 8.","DOI":"10.3390\/jof8040413"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1130-1406(07)70022-0","article-title":"The epidemiology of coccidioidomycosis in Mexico","volume":"24","author":"Riquelme","year":"2007","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_5","first-page":"44","article-title":"The Probable Geographic Distribution of Coccidioides immitis in Mexico","volume":"57","author":"Maddy","year":"1964","journal-title":"Bolet\u00edn Oficina Sanit. Panam."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11046-020-00431-2","article-title":"Re-drawing the Maps for Endemic Mycoses","volume":"185","author":"Ashraf","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_7","unstructured":"CDC (2024, May 01). Valley Fever (Coccidioidomycosis) Statistics, Available online: https:\/\/www.cdc.gov\/valley-fever\/hcp\/clinical-overview\/index.html."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/myc.12394","article-title":"Burden of serious fungal infections in Mexico","volume":"58","author":"Denning","year":"2015","journal-title":"Mycoses"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Salazar-Hamm, P., and Torres-Cruz, T.J. (2024). The Impact of Climate Change on Human Fungal Pathogen Distribution and Disease Incidence. Curr. Clin. Microbiol. Rep.","DOI":"10.1007\/s40588-024-00224-x"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1029\/2019GH000209","article-title":"Expansion of Coccidioidomycosis Endemic Regions in the United States in Response to Climate Change","volume":"3","author":"Gorris","year":"2019","journal-title":"Geohealth"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1093\/mmy\/myy037","article-title":"Coccidioidomycosis in Latin America","volume":"57","author":"Arathoon","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_12","unstructured":"World Health Organization (2022). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action, World Health Organization."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.amjmed.2008.12.024","article-title":"The Spectrum and Presentation of Disseminated Coccidioidomycosis","volume":"122","author":"Adam","year":"2009","journal-title":"Am. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40138-023-00274-3","article-title":"Coccidioidomycosis Update and Review","volume":"11","author":"Schneider","year":"2023","journal-title":"Curr. Emerg. Hosp. Med. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3201\/eid2302.160505","article-title":"Risk factors for disseminated coccidioidomycosis, United States","volume":"23","author":"Odio","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Galgiani, J.N., Hsu, A.P., Powell, D.A., Vyas, J.M., and Holland, S.M. (2023). Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician\u2019s Perspective. J. Fungi, 9.","DOI":"10.3390\/jof9050554"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the european organization for research and treatment of cancer and the mycoses study group education and research consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gorris, M.E., Ardon-Dryer, K., Campuzano, A., Casta\u00f1\u00f3n-Olivares, L.R., Gill, T.E., Greene, A., Hung, C.Y., Kaufeld, K.A., Lacy, M., and S\u00e1nchez-Paredes, E. (2023). Advocating for Coccidioidomycosis to Be a Reportable Disease Nationwide in the United States and Encouraging Disease Surveillance across North and South America. J. Fungi, 9.","DOI":"10.3390\/jof9010083"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ampel, N.M. (2020). Coccidioidomycosis: Changing concepts and knowledge gaps. J. Fungi, 6.","DOI":"10.3390\/jof6040354"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e793","DOI":"10.1016\/S2542-5196(22)00202-9","article-title":"Effects of precipitation, heat, and drought on incidence and expansion of coccidioidomycosis in western USA: A longitudinal surveillance study","volume":"6","author":"Head","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1086\/319203","article-title":"Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995\u20131996","volume":"32","author":"Rosenstein","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12281-023-00479-9","article-title":"Climate Change Exacerbating Fungal Disease Disparities","volume":"18","author":"Bonifaz","year":"2024","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"ofac032","DOI":"10.1093\/ofid\/ofac032","article-title":"Contribution of Biologic Response Modifiers to the Risk of Coccidioidomycosis Severity","volume":"9","author":"Donovan","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1093\/mmy\/myy019","article-title":"Coccidioidomycosis in selected immunosuppressed hosts","volume":"57","author":"Blair","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_25","first-page":"442","article-title":"Type 2 Diabetes and its Impact on the Immune System","volume":"16","author":"Berbudi","year":"2019","journal-title":"Curr. Diabetes Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3201\/eid0505.990508","article-title":"Influence of host genetics on the severity of coccidioidomycosis","volume":"5","author":"Louie","year":"1999","journal-title":"Emerg. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.amjmed.2006.03.033","article-title":"Coccidioidomycosis in Patients with Diabetes Mellitus","volume":"119","author":"Santelli","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.riam.2017.03.006","article-title":"Diagnosis of coccidioidomycosis in a non-endemic area: Inference of the probable geographic area of an infection","volume":"34","author":"Arenas","year":"2017","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Stevens, D.A., Martinez, M., Sass, G., Pappagianis, D., Doherty, B., Kutsche, H., and McGuire, M. (2020). Comparative study of newer and established methods of diagnosing coccidioidal meningitis. J. Fungi., 6.","DOI":"10.3390\/jof6030125"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/cid\/ciaa188","article-title":"Advances in Diagnosis of Progressive Pulmonary and Disseminated Coccidioidomycosis","volume":"72","author":"Kassis","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mead, H.L., Van Dyke, M.C.C., and Barker, B.M. (2020). Proper Care and Feeding of Coccidioides: A Laboratorian\u2019s Guide to Cultivating the Dimorphic Stages of C. immitis and C. posadasii. Curr. Protoc. Microbiol., 58.","DOI":"10.1002\/cpmc.113"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/10\/6\/429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:00:32Z","timestamp":1760108432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/10\/6\/429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jof10060429"],"URL":"https:\/\/doi.org\/10.3390\/jof10060429","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]}}}