{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:36:17Z","timestamp":1788568577536,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zepto Life Technology Inc.","award":["#HRP-595"],"award-info":[{"award-number":["#HRP-595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>We present a case of a man immunocompromised due to myelodysplastic syndrome with Candida krusei fungemia who had a rising cell-free DNA (cfDNA) giant magnetoresistance (GMR) signal when tested daily using plasma blood samples. With the rise in GMR signal paralleling the development of skin lesions in this patient, we conclude that cfDNA can be used to indicate uncontrolled infection and thus help monitor response to therapy. This index patient provides evidence that an invasive fungal infection requires both direct antifungal therapy and an intact immune system to control the infection. This biosensing platform has been simplified to potentially serve as a point-of-care test, setting it apart by overcoming the three common barriers of cfDNA testing: complexity, cost, and time.<\/jats:p>","DOI":"10.3390\/jof10070449","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T04:19:26Z","timestamp":1719461966000},"page":"449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-341X","authenticated-orcid":false,"given":"Jo-Anne H.","family":"Young","sequence":"first","affiliation":[{"name":"Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Liu","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Porter","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Sweet","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton F.","family":"Evans","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zepto Life Technology, Inc., Saint Paul, MN 55114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-647X","authenticated-orcid":false,"given":"Karam M.","family":"Obeid","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. 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