{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:14:21Z","timestamp":1766441661923,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mazandaran University of Medical Sciences (grant no.9214).","award":["9214"],"award-info":[{"award-number":["9214"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida auris, an emerging non-albicans multidrug-resistant yeast, has become a significant cause of invasive candidiasis in healthcare settings. So far, data on the metabolites of C. auris in different clades are minimal, and no studies have focused on clade V metabolites. Therefore, Gas chromatography\u2013mass spectrometry (GC-MS) was used for the metabolomic profiling of clade I C. auris compared with fluconazole-resistant and susceptible C. auris in clade V strains. GC-MS chromatography revealed 28, 22, and 30 compounds in methanolic extracts of the fluconazole-susceptible and fluconazole-resistant C. auris clade V and C. auris clade I strain, respectively. Some compounds, such as acetamide and metaraminol, were found in fluconazole-susceptible and resistant C. auris clade V and clade I. N-methyl-ethanamine and bis(2-ethylhexyl) phthalate metabolites were found in both fluconazole -susceptible and resistant C. auris clade V, as well as 3-methyl-4-isopropylphenol, 3,5-bis(1,1-dimethyl)-1,2-benzenediol, and diisostyl phthalate metabolites in both fluconazole resistant C. auris clade V and I. Identifying these metabolites contributes to understanding the morphogenesis and pathogenesis of C. auris, highlighting their potential role in antifungal drug resistance and the control of fungal growth. However, further experiments are warranted to fully comprehend the identified metabolites\u2019 regulatory responses, and there may be potential challenges in translating these findings into clinical applications.<\/jats:p>","DOI":"10.3390\/jof10080518","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:31:07Z","timestamp":1721917867000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic Patterns of Fluconazole Resistant and Susceptible Candida auris Clade V and I"],"prefix":"10.3390","volume":"10","author":[{"given":"Robab Ebrahimi","family":"Barough","sequence":"first","affiliation":[{"name":"Student Research Committee, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-2518","authenticated-orcid":false,"given":"Javad","family":"Javidnia","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Davoodi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biotechnology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Talebpour Amiri","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Moazeni","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahabeddin","family":"Sarvi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Communicable Diseases Institute, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-6994","authenticated-orcid":false,"given":"Reza","family":"Valadan","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Molecular and Cell-Biology Research Center, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Siahposht-Khachaki","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Mazandaran University of Medical Sciences, Ramsar International Branch, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-514X","authenticated-orcid":false,"given":"Mahmood","family":"Moosazadeh","sequence":"additional","affiliation":[{"name":"Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-7485","authenticated-orcid":false,"given":"Mohsen","family":"Nosratabadi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Haghani","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology, Radboud University Medical Center, Canisius Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands"},{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Excellence Center for Medical Mycology (ECMM), University of Cologne, 50923 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-2849","authenticated-orcid":false,"given":"Mahdi","family":"Abastabar","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran"},{"name":"Department of Medical Mycology, School of 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