{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:17:17Z","timestamp":1790709437670,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["RUN\/21\/001 and C14\/20\/095"],"award-info":[{"award-number":["RUN\/21\/001 and C14\/20\/095"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["813120"],"award-info":[{"award-number":["813120"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["G067023N"],"award-info":[{"award-number":["G067023N"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sklodowska-Curie grant agreement","award":["RUN\/21\/001 and C14\/20\/095"],"award-info":[{"award-number":["RUN\/21\/001 and C14\/20\/095"]}]},{"name":"Marie Sklodowska-Curie grant agreement","award":["813120"],"award-info":[{"award-number":["813120"]}]},{"name":"Marie Sklodowska-Curie grant agreement","award":["G067023N"],"award-info":[{"award-number":["G067023N"]}]},{"name":"CryptoVIEW","award":["RUN\/21\/001 and C14\/20\/095"],"award-info":[{"award-number":["RUN\/21\/001 and C14\/20\/095"]}]},{"name":"CryptoVIEW","award":["813120"],"award-info":[{"award-number":["813120"]}]},{"name":"CryptoVIEW","award":["G067023N"],"award-info":[{"award-number":["G067023N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The controversially discussed taxonomy of the Cryptococcus neoformans\/Cryptococcus gattii species complex encompasses at least eight major molecular types. Cerebral cryptococcomas are a common manifestation of cryptococcal neurological disease. In this study, we compared neurotypical symptoms and differential neurovirulence induced by one representative isolate for each of the eight molecular types studied. We compared single focal lesions caused by the different isolates and evaluated the potential relationships between the fungal burden and properties obtained with quantitative magnetic resonance imaging (qMRI) techniques such as diffusion MRI, T2 relaxometry and magnetic resonance spectroscopy (MRS). We observed an inverse correlation between parametric data and lesion density, and we were able to monitor longitudinally biophysical properties of cryptococcomas induced by different molecular types. Because the MRI\/MRS techniques are also clinically available, the same approach could be used to assess image-based biophysical properties that correlate with fungal cell density in lesions in patients to determine personalized treatments.<\/jats:p>","DOI":"10.3390\/jof10080593","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T03:32:01Z","timestamp":1724643121000},"page":"593","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative MRI of a Cerebral Cryptococcoma Mouse Model for In Vivo Distinction between Different Cryptococcal Molecular Types"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1880-146X","authenticated-orcid":false,"given":"Luigi","family":"Musetta","sequence":"first","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4123-5725","authenticated-orcid":false,"given":"Shannon","family":"Helsper","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6345-9428","authenticated-orcid":false,"given":"Lara","family":"Roosen","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dries","family":"Maes","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Croitor Sava","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-5401","authenticated-orcid":false,"given":"Liesbeth","family":"Vanherp","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"},{"name":"\u00b5NEURO Research Centre of Excellence, University of Antwerp, 2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-6107","authenticated-orcid":false,"given":"Willy","family":"Gsell","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-3993","authenticated-orcid":false,"given":"Greetje","family":"Vande Velde","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-1350","authenticated-orcid":false,"given":"Katrien","family":"Lagrou","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Laboratory Medicine, National Reference Center for Mycosis, UZ Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Meyer","sequence":"additional","affiliation":[{"name":"Westerdjjk Fungal Biodiversity Institute\u2014KNAW, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-8895","authenticated-orcid":false,"given":"Uwe","family":"Himmelreich","sequence":"additional","affiliation":[{"name":"Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0891-5520(02)00036-3","article-title":"Cryptococcosis","volume":"16","author":"Perfect","year":"2002","journal-title":"Infect. 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