{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:42:03Z","timestamp":1791934923180,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council Centre for Medical Mycology","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]},{"name":"NIHR Exeter Biomedical Research Centre","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]},{"name":"NIHR Exeter Clinical Research Facility","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]},{"name":"UK CF Trust Strategic Research Centre Award","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]},{"name":"UK CF Trust and the National Institute for Health and Research (NIHR) Imperial Biomedical Research Centre","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]},{"name":"Royal Brompton Clinical Research Facility","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Observational studies indicate that Aspergillus colonization and allergic bronchopulmonary aspergillosis (ABPA) in people with cystic fibrosis (CF) are associated with poorer lung health and increased disease severity. We performed a longitudinal observational cohort study to analyse long-term outcomes of Aspergillus colonization and ABPA in children with CF. Anonymised UK CF Registry data from 2009 to 2019 for patients aged 8\u201317 years in 2009\u20132010 were collected. For the baseline cohort analysis, patients were classified based on the presence of Aspergillus colonization and ABPA in 2009 and\/or 2010. For the longitudinal analysis, patients were categorised according to annual Aspergillus colonization and ABPA status. Comparisons made were (1) Aspergillus positive vs. negative; (2) excluding those with ABPA: Aspergillus positive vs. negative; and (3) ABPA positive vs. negative. Primary outcome was percentage predicted FEV1 decline and secondary outcomes included BMI decline, mortality, lung transplant, and IV antibiotic use. Of the 1675 children, 263 had Aspergillus colonization in the baseline cohort, 260 were diagnosed with ABPA, and 80 had both. Baseline cohort analysis showed significantly lower lung function (p &lt; 0.0001) and increased antibiotic treatment (p &lt; 0.001) in those with Aspergillus colonization and in those with ABPA. Longitudinal analysis showed ABPA was associated with increased decline in lung function (p &lt; 0.00001) and BMI (p &lt; 0.00001). Aspergillus colonization was associated with increased decline in BMI (p = 0.005) but not lung function (p = 0.30). ABPA was associated with increased decline in long-term lung function and BMI in children and young people with CF. Aspergillus colonization was associated with lower lung function at baseline, but no increased rate of decline was observed long-term.<\/jats:p>","DOI":"10.3390\/jof10090599","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T03:32:01Z","timestamp":1724643121000},"page":"599","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-Term Outcomes of Allergic Bronchopulmonary Aspergillosis and Aspergillus Colonization in Children and Adolescents with Cystic Fibrosis"],"prefix":"10.3390","volume":"10","author":[{"given":"Emily","family":"Chesshyre","sequence":"first","affiliation":[{"name":"MRC Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK"},{"name":"Department of Paediatrics, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3833-0182","authenticated-orcid":false,"given":"Fiona C.","family":"Warren","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-308X","authenticated-orcid":false,"given":"Angela C.","family":"Shore","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK"},{"name":"NIHR Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Davies","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College, London SW3 6LY, UK"},{"name":"Royal Brompton and Harefield Hospitals, London SW3 6NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Armstrong-James","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals, London SW3 6NP, UK"},{"name":"Department of Infectious Diseases, Imperial College, London W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-3358","authenticated-orcid":false,"given":"Adilia","family":"Warris","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK"},{"name":"Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jcf.2018.02.006","article-title":"ECFS best practice guidelines: The 2018 revision","volume":"17","author":"Castellani","year":"2018","journal-title":"J. Cyst. Fibros."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1513\/AnnalsATS.201404-166OC","article-title":"Cystic fibrosis foundation pulmonary guideline pharmacologic approaches to prevention and Eradication of Initial Pseudomonas aeruginosa Infection","volume":"11","author":"Mogayzel","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1002\/ppul.25641","article-title":"Structural lung disease following allergic bronchopulmonary aspergillosis complicating pediatric cystic fibrosis","volume":"56","author":"McCashney","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jcf.2021.07.008","article-title":"Clinician variability in the diagnosis and treatment of aspergillus fumigatus-related conditions in cystic fibrosis: An international survey","volume":"21","author":"Hong","year":"2022","journal-title":"J. Cyst. Fibros."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Reece, E., Segurado, R., Jackson, A., McClean, S., Renwick, J., and Greally, P. (2017). Co-colonisation with Aspergillus fumigatus and Pseudomonas aeruginosa is associated with poorer health in cystic fibrosis patients: An Irish registry analysis. BMC Pulm. Med., 17.","DOI":"10.1186\/s12890-017-0416-4"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0140-6736(19)32597-8","article-title":"Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: A double-blind, randomised, phase 3 trial","volume":"394","author":"Heijerman","year":"2019","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1908639","article-title":"Elexacaftor\u2013Tezacaftor\u2013Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele","volume":"381","author":"Middleton","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_8","unstructured":"Naito, Y., Charman, S., Duckers, J., and Clarke, S. (2023). UK Cystic Fibrosis Registry Annual Data Report 2022, UK Cystic Fibrosis Trust."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/cea.12595","article-title":"Prevalence of Aspergillus sensitization and allergic bronchopulmonary aspergillosis in cystic fibrosis: Systematic review and meta-analysis","volume":"45","author":"Maturu","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1086\/376525","article-title":"Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis\u2014State of the Art: Cystic Fibrosis Foundation Consensus Conference","volume":"37","author":"Stevens","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2400061","DOI":"10.1183\/13993003.00061-2024","article-title":"Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis\/mycoses","volume":"63","author":"Agarwal","year":"2024","journal-title":"Eur. Respir. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/archdischild-2016-311132","article-title":"Effect of allergic bronchopulmonary aspergillosis on FEV1 in children and adolescents with cystic fibrosis: A European Cystic Fibrosis Society Patient Registry analysis","volume":"102","author":"Kaditis","year":"2017","journal-title":"Arch. Dis. Child."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1034\/j.1399-3003.2000.016003464.x","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study","volume":"16","author":"Mastella","year":"2000","journal-title":"Eur. Respir. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3109\/00365548.2012.695454","article-title":"Assessment of Aspergillus sensitization or persistent carriage as a factor in lung function impairment in cystic fibrosis patients","volume":"44","author":"Fillaux","year":"2012","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1164\/rccm.200603-423OC","article-title":"Effect of allergic bronchopulmonary aspergillosis on lung function in children with cystic fibrosis","volume":"174","author":"Kraemer","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"D\u00fcesberg, U., Wosniok, J., Naehrlich, L., Eschenhagen, P., and Schwarz, C. (2020). Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-75886-w"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1093\/mmy\/myy074","article-title":"Aspergillus colonization and antifungal immunity in cystic fibrosis patients","volume":"57","author":"Warris","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1378\/chest.09-1103","article-title":"The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis","volume":"137","author":"Amin","year":"2010","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Blomquist, A., Inghammar, M., Al Shakirchi, M., Ericson, P., Krantz, C., Svedberg, M., Lindblad, A., and P\u00e5hlman, L.I. (2022). Persistent Aspergillus fumigatus infection in cystic fibrosis: Impact on lung function and role of treatment of asymptomatic colonization-a registry-based case-control study. BMC Pulm. Med., 22.","DOI":"10.1186\/s12890-022-02054-3"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/mmy\/myu038","article-title":"Inhaled corticosteroids and Aspergillus fumigatus isolation in cystic fibrosis","volume":"52","author":"Noni","year":"2014","journal-title":"Med. Mycol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jcf.2021.04.007","article-title":"Clinical characteristics of Pseudomonas and Aspergillus co-infected cystic fibrosis patients: A UK registry study","volume":"21","author":"Hughes","year":"2022","journal-title":"J. Cyst. Fibros."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s10096-015-2474-y","article-title":"Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship","volume":"34","author":"Noni","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1569-1993(02)00141-8","article-title":"Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients","volume":"2","author":"Lee","year":"2003","journal-title":"J. Cyst. Fibros."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jcf.2016.01.004","article-title":"Microbial colonization and lung function in adolescents with cystic fibrosis","volume":"15","author":"Hector","year":"2016","journal-title":"J. Cyst. Fibros."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jcf.2022.03.008","article-title":"Factors in childhood associated with lung function decline to adolescence in cystic fibrosis","volume":"21","author":"Begum","year":"2022","journal-title":"J. Cyst. Fibros."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/thoraxjnl-2018-211550","article-title":"Aspergillus and progression of lung disease in children with cystic fibrosis","volume":"74","author":"Harun","year":"2019","journal-title":"Thorax"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1164\/rccm.201908-1585OC","article-title":"Aspergillus infections and progression of structural lung disease in children with cystic fibrosis","volume":"201","author":"Breuer","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S280","DOI":"10.1016\/S1569-1993(22)01185-7","article-title":"495 Identification of airway Aspergillus fumigatus infection\u2013use of cough swabs is not a suitable alternative to fungal sputum culture","volume":"21","author":"Francis","year":"2022","journal-title":"J. Cyst. Fibros."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1513\/AnnalsATS.202210-852OC","article-title":"The clinical association between Aspergillus fumigatus and respiratory outcomes in adolescents and adults with cystic fibrosis","volume":"20","author":"Feng","year":"2023","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cmi.2019.11.019","article-title":"High-volume culture and quantitative real-time PCR for the detection of Aspergillus in sputum","volume":"26","author":"Vergidis","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Al Shakirchi, M., Sorjonen, K., Klingspor, L., Bergman, P., Hjelte, L., and de Monestrol, I. (2021). The effects of Aspergillus fumigatus colonization on lung function in patients with cystic fibrosis. J. Fungi, 7.","DOI":"10.3390\/jof7110944"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1164\/rccm.201407-1277OC","article-title":"Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis","volume":"190","author":"Ramsey","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/mmy\/myy014","article-title":"The diagnosis and management of respiratory tract fungal infection in cystic fibrosis: A UK survey of current practice","volume":"57","author":"Boyle","year":"2019","journal-title":"Med. Mycol."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/10\/9\/599\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:42:50Z","timestamp":1760110970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/10\/9\/599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,24]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jof10090599"],"URL":"https:\/\/doi.org\/10.3390\/jof10090599","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,24]]}}}