{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:31:52Z","timestamp":1792704712641,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Purpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratitis from nine hospitals within the region of Galicia, Spain, between 2010 and 2020. Data obtained from clinical records were analysed. Results: Out of 654 cases of infectious keratitis, 77 cases (9.9%) were identified as fungal keratitis. The median age of affected patients was 68.0 years, with a higher incidence in rural areas (62.3%). Candida spp. infections were the most frequent type (55.8%) and were associated with a higher median age than were the non-dermatophyte mould infections. The primary risk factors included steroid eyedrop use (29.9%), recent keratoplasty (18.2%), ocular trauma (19.5%), and contact with vegetable matter (11.7%). Most ulcers displayed stromal involvement, and 37.7% presented corneal thinning. The median duration of infection was longer in fungal than in bacterial keratitis, and surgical intervention was required in 48.1% of cases. Conclusions: Fungal keratitis, mainly involving Candida spp., accounted for 9.9% of microbial keratitis cases in Galicia, Spain, with significant risk factors being topical steroid use, ocular trauma, and contact with vegetable matter. Delayed diagnosis often resulted in poor outcomes, highlighting the need for early detection through awareness and new technologies to improve prognosis.<\/jats:p>","DOI":"10.3390\/jof10100689","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:08:47Z","timestamp":1727780927000},"page":"689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-8773","authenticated-orcid":false,"given":"David","family":"Lamas-Francis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Santiago de Compostela, Ram\u00f3n Baltar s\/n, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-2919","authenticated-orcid":false,"given":"Raquel","family":"Mansilla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Vigo, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-0007","authenticated-orcid":false,"given":"Victoria","family":"de-Rojas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Ourense, 32005 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Dios","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Pontevedra, 36161 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Rigueiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Lucus Augusti, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Ferrol, 15401 Ferrol, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Crego","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital P\u00fablico da Mari\u00f1a, 27880 Burela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rodr\u00edguez-Ares","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Santiago de Compostela, Ram\u00f3n Baltar s\/n, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Touri\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Santiago de Compostela, Ram\u00f3n Baltar s\/n, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The Global Incidence and Diagnosis of Fungal Keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect. 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