{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:14:52Z","timestamp":1774314892582,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Objectives: Chronic pulmonary aspergillosis (CPA) is a fungal lung infection characterised by the slowly progressing destruction of the lung parenchyma and has four main subtypes. The objective of this work was to evaluate the epidemiology of CPA in our area and evaluate the involvement of the different subtypes in mortality. Methods: This was a descriptive longitudinal retrospective study developed in three tertiary hospitals in Spain. Among all patients admitted with a pulmonary aspergillosis diagnosis, we selected those who fulfilled the criteria for chronic aspergillosis according to the criteria of Denning, excluding those with a haematological disorder. Results: Among 409 inpatients recorded as having a pulmonary aspergillosis infection, only 76 (18.5%) fulfilled the criteria for CPA, with an estimated incidence of 0.67 cases\/100,000 inhabitants\/year. The subtypes detected were subacute invasive aspergillosis (SAIA) in 33 (43.4%) patients, simple aspergilloma (SA) in 25 (32.9%) patients, cavitary chronic aspergillosis (CCPA) in 13 (17.1%) patients, and chronic fibrosis (CFPA) in five (6.5%) patients. The overall three-month mortality rate was 23%, which was higher in SAIA patients. The predictors of early mortality were age &gt; 65 years (OR 3.0 CI 95 1.0\u20139.5 p = 0.043) and the SAIA subtype vs. other subtypes (OR 3.1 CI 95 1.0\u20139.5 p = 0.042). Conclusions: The incidence rate estimated was inferior to that previously reported. The three-month mortality in patients with CPA was high, with older age and the SAIA subtype being the variable independent predictors of a worse prognosis.<\/jats:p>","DOI":"10.3390\/jof10100706","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T07:54:09Z","timestamp":1728546849000},"page":"706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Three-Month Mortality in Nonhaematological Patients with Chronic Pulmonary Aspergillosis: Differences between Subtypes"],"prefix":"10.3390","volume":"10","author":[{"given":"Pablo","family":"Gonz\u00e1lez Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Valdecilla (IDIVAL), Universidad de Cantabria, 39008 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Fern\u00e1ndez-Navarro","sequence":"additional","affiliation":[{"name":"Complejo Asistencial de Salamanca (CAUSA), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Universidad de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Bru-Arca","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Rio Carri\u00f3n, 34005 Palencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"\u00c1lvarez-Artero","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas, Hospital Rio Carri\u00f3n, 34005 Palencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4957-4219","authenticated-orcid":false,"given":"Pablo","family":"Sol\u00eds","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Marqu\u00e9s de Valdecilla, 39501 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-8128","authenticated-orcid":false,"given":"Mar\u00eda P\u00eda","family":"Roiz Mesones","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Marqu\u00e9s de Valdecilla, CIBERINFEC, ISCIII, IDIVAL, 39501 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-8785","authenticated-orcid":false,"given":"Juan Luis","family":"Mu\u00f1oz Bellido","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, CAUSA, IBSAL, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Universidad de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Antonia","family":"Garc\u00eda Castro","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Rio Carri\u00f3n, 34005 Palencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-1256","authenticated-orcid":false,"given":"Moncef","family":"Belhassen-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Infecciosas, CAUSA, IBSAL, CIETUS, Universidad de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-7877","authenticated-orcid":false,"given":"Javier","family":"Pardo Lled\u00edas","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Valdecilla (IDIVAL), Universidad de Cantabria, 39008 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4269\/ajtmh.22-0366","article-title":"Imaging Spectrum in Chronic Pulmonary Aspergillosis","volume":"108","author":"Garg","year":"2023","journal-title":"Am. 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