{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:19:06Z","timestamp":1789676346741,"version":"4.0.1"},"reference-count":65,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (ANPCyT)","award":["PICT 2020-03973"],"award-info":[{"award-number":["PICT 2020-03973"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (ANPCyT)","award":["PICT 2019-02866"],"award-info":[{"award-number":["PICT 2019-02866"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (ANPCyT)","award":["PICTA 2021-0060"],"award-info":[{"award-number":["PICTA 2021-0060"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (ANPCyT)","award":["FITBA A09\u20132022"],"award-info":[{"award-number":["FITBA A09\u20132022"]}]},{"name":"Ministry of Production, Science, and Technology from Provincia de Buenos Aires","award":["PICT 2020-03973"],"award-info":[{"award-number":["PICT 2020-03973"]}]},{"name":"Ministry of Production, Science, and Technology from Provincia de Buenos Aires","award":["PICT 2019-02866"],"award-info":[{"award-number":["PICT 2019-02866"]}]},{"name":"Ministry of Production, Science, and Technology from Provincia de Buenos Aires","award":["PICTA 2021-0060"],"award-info":[{"award-number":["PICTA 2021-0060"]}]},{"name":"Ministry of Production, Science, and Technology from Provincia de Buenos Aires","award":["FITBA A09\u20132022"],"award-info":[{"award-number":["FITBA A09\u20132022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Global concern about pathogenic resistance to antibiotics is prompting interest in probiotics as a strategy to prevent or inhibit infections. Fermented beverages are promising sources of probiotic yeasts. This study aimed to evaluate the antagonistic effects of Kluyveromyces marxianus, Wickerhamomyces anomalus, and Pichia manshurica strains from kefir and wine against Salmonella enterica serovar Enteritidis in intestinal epithelial cells. The ability of these yeasts to adhere to Caco-2\/TC-7 cells was evaluated, as well as their influence on the ability of Salmonella to associate and invade these cells. The behavior of the pathogen was analyzed by (a) incubation of enterocytes with yeast before adding Salmonella, (b) co-incubation of Salmonella with yeast before contact with the enterocytes, and (c) incubation of Salmonella with yeast metabolites before contact with enterocytes. All yeast strains demonstrated adherence to Caco-2\/TC-7 cells (33\u2013100%) and effectively inhibited Salmonella invasion. Among the treatments, co-culture showed the greatest effect, reducing Salmonella association and invasion by more than 50%. Additionally, these yeasts modulated the epithelial immune response, significantly decreasing CCL20-driven luminescence by 60\u201381% (p &lt; 0.0001). These results highlight the potential of yeasts from fermented beverages as probiotics to counteract Salmonella infections, offering a promising alternative in the fight against antibiotic resistance.<\/jats:p>","DOI":"10.3390\/jof10120878","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T06:26:12Z","timestamp":1734416772000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Probiotic Potential of Yeasts Isolated from Fermented Beverages: Assessment of Antagonistic Strategies Against Salmonella enterica Serovar Enteritidis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0072-7694","authenticated-orcid":false,"given":"Silvia Cristina Vergara","family":"Alvarez","sequence":"first","affiliation":[{"name":"Instituto de Biotecnolog\u00eda, Universidad Nacional de San Juan, Av. San Mart\u00edn 1109 (O), San Juan 5400, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7525-8991","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Pend\u00f3n","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"},{"name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos (CIDCA), CONICET-UNLP-CIC, Street 47 and 116, La Plata 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-618X","authenticated-orcid":false,"given":"Ana Agustina","family":"Bengoa","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"},{"name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos (CIDCA), CONICET-UNLP-CIC, Street 47 and 116, La Plata 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-4992","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Leiva Alaniz","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda, Universidad Nacional de San Juan, Av. San Mart\u00edn 1109 (O), San Juan 5400, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-7836","authenticated-orcid":false,"given":"Yolanda Paola","family":"Maturano","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda, Universidad Nacional de San Juan, Av. San Mart\u00edn 1109 (O), San Juan 5400, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-7216","authenticated-orcid":false,"given":"Graciela Liliana","family":"Garrote","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz 2290, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"},{"name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos (CIDCA), CONICET-UNLP-CIC, Street 47 and 116, La Plata 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, G., Song, Q., Huang, S., Wang, Y., Cai, S., Yu, H., Ding, X., Zeng, X., and Zhang, J. 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