{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:49:50Z","timestamp":1782139790461,"version":"3.54.5"},"reference-count":107,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Background: Systemic Candida infection (SCI) is the third most common cause of late-onset sepsis in Neonatal Intensive Care Units (NICU). While platelet involvement in fungal infections has been extensively studied, evaluation of the hemostatic mechanism in Candida infections, especially in neonates, has not been widely investigated. The aim of the current study was to evaluate the hemostatic profile of neonates with SCI through rotational thromboelastometry (ROTEM), a laboratory method that assesses the viscoelastic properties of blood. Methods: This is a single-centered prospective cohort study including a group of neonates with SCI (n = 21); the control group consisted of healthy neonates (n = 24). Demographics, clinical parameters, and laboratory data were recorded at the disease onset. Neonatal scores for the assessment of disease severity (Modified NEOMOD, nSOFA, and NeoBAT) were also calculated. ROTEM parameters of neonates with SCI were compared to those of healthy neonates. Results: ROTEM parameters differed between neonates with SCI and healthy neonates, indicating a hypocoagulable profile of infected neonates. Specifically, neonates with SCI had significantly prolonged clotting time (CT) and clot formation time (CFT), as well as lower clot amplitude at 10 min (A10) and maximum clot firmness (MCF) when compared to healthy neonates (p values &lt; 0.05), findings that remained consistent after adjusting for confounding factors such as gestational age, birth weight, and sex. In addition, a strong correlation was noted between ROTEM parameters and disease severity based on the modified NEOMOD, nSOFA, and NeoBAT scores. Conclusions: ROTEM parameters revealed a hypocoagulable profile in neonates during the early stages of SCI, which is also associated with disease severity. The results of this study highlight the need for monitoring of hemostatic status of this vulnerable group of patients and indicate that ROTEM analysis may have a role in the early detection of the hemostatic derangements associated with SCI in neonates, in order to ensure timely diagnosis and targeted therapeutic intervention.<\/jats:p>","DOI":"10.3390\/jof11010017","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:34:19Z","timestamp":1735630459000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8901","authenticated-orcid":false,"given":"Rozeta","family":"Sokou","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"},{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia Eleftheria","family":"Palioura","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-6826","authenticated-orcid":false,"given":"Aikaterini","family":"Konstantinidi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-8672","authenticated-orcid":false,"given":"Alexandra","family":"Lianou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lampridou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Theodoraki","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-6639","authenticated-orcid":false,"given":"Daniele","family":"Piovani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina A.","family":"Tsante","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttikon\u201d Hospital, National and Kapodistrian University of Athens Medical School, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1082-5674","authenticated-orcid":false,"given":"Petros","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine & Infectious Diseases, University General Hospital of Heraklion, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-6191","authenticated-orcid":false,"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttikon\u201d Hospital, National and Kapodistrian University of Athens Medical School, 12462 Athens, Greece"},{"name":"Microbiology Department, \u201cSaint Savvas\u201d Oncology Hospital, 11522 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Caggiano, G., Lovero, G., De Giglio, O., Barbuti, G., Montagna, O., Laforgia, N., and Montagna, M.T. (2017). Candidemia in the Neonatal Intensive Care Unit: A Retrospective, Observational Survey and Analysis of Literature Data. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/7901763"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1542\/peds.2004-2292","article-title":"Neonatal candidiasis among extremely low birth weight infants: Risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months","volume":"117","author":"Benjamin","year":"2006","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kaur, H., and Chakrabarti, A. (2017). Strategies to Reduce Mortality in Adult and Neonatal Candidemia in Developing Countries. J. Fungi, 3.","DOI":"10.3390\/jof3030041"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.clp.2014.10.008","article-title":"The epidemiology and diagnosis of invasive candidiasis among premature infants","volume":"42","author":"Kelly","year":"2015","journal-title":"Clin. Perinatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/INF.0b013e3182769603","article-title":"Risk factors for invasive candidiasis in infants >1500 g birth weight","volume":"32","author":"Lee","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kopanou Taliaka, P., Tsantes, A.G., Konstantinidi, A., Houhoula, D., Tsante, K.A., Vaiopoulos, A.G., Piovani, D., Nikolopoulos, G.K., Bonovas, S., and Iacovidou, N. (2023). Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature. Life, 13.","DOI":"10.3390\/life13010167"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.idc.2005.05.007","article-title":"Neonatal Candidiasis","volume":"19","author":"Smith","year":"2005","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Molla, A., and Albadrani, M. (2024). Prevalence and Species Distribution of Neonatal Candidiasis: A Systematic Review and Meta-Analysis. Diseases, 12.","DOI":"10.3390\/diseases12070154"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/NPM-17121","article-title":"Prophylactic regimens with fluconazole for candidiasis in neonates under 1.500 g: A retrospective chart review of two cohorts","volume":"12","author":"Camargos","year":"2019","journal-title":"J. Neonatal-Perinat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1542\/peds.2005-2677","article-title":"The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants","volume":"118","author":"Cotten","year":"2006","journal-title":"Pediatrics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S2352-4642(21)00272-8","article-title":"Neonatal invasive candidiasis: Updates on clinical management and prevention","volume":"6","author":"Kilpatrick","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0732-8893(93)90020-8","article-title":"Lysis\u2014Centrifugation blood cultures in the detection of tissue-proven invasive candidiasis disseminated versus single-organ infection","volume":"17","author":"Berenguer","year":"1993","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/cid\/cit006","article-title":"Finding the \u201cmissing 50%\u201d of invasive candidiasis: How nonculture diagnostics will improve understanding of disease spectrum and transform patient care","volume":"56","author":"Clancy","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e865","DOI":"10.1542\/peds.2009-3412","article-title":"Neonatal candidiasis: Epidemiology, risk factors, and clinical judgment","volume":"126","author":"Benjamin","year":"2010","journal-title":"Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/mmy.39.1.75.79","article-title":"Candidal and bacterial bloodstream infections in premature neonates: A case-control study","volume":"39","author":"Warris","year":"2001","journal-title":"Sabouraudia"},{"key":"ref_17","first-page":"139","article-title":"The relationship between inflammation and the coagulation system","volume":"136","author":"Choi","year":"2006","journal-title":"Swiss Med. Wkly."},{"key":"ref_18","first-page":"71","article-title":"Interaction between the coagulation and complement system","volume":"632","author":"Amara","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1590\/S0074-0276108042013015","article-title":"Interaction between Paracoccidioides brasiliensis conidia and the coagulation system: Involvement of fibrinogen","volume":"108","author":"Tamayo","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1086\/591458","article-title":"Human platelets attenuate Aspergillus species via granule-dependent mechanisms","volume":"198","author":"Perkhofer","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e00784-19","DOI":"10.1128\/IAI.00784-19","article-title":"Stepping Up to the Plate(let) against Candida albicans","volume":"88","author":"Schultz","year":"2020","journal-title":"Infect. Immun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1515\/cclm-2016-0931","article-title":"Reference ranges of thromboelastometry in healthy full-term and pre-term neonates","volume":"55","author":"Sokou","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0042-1753513","article-title":"The Utility of NATEM Assay in Predicting Bleeding Risk in Critically Ill Neonates","volume":"49","author":"Sokou","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00431-017-3072-z","article-title":"Thromboelastometry for diagnosis of neonatal sepsis-associated coagulopathy: An observational study","volume":"177","author":"Sokou","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.placenta.2022.09.012","article-title":"The impact of maternal smoking during pregnancy on hemostatic profile of neonates using thromboelastometry (ROTEM). A pilot observational study","volume":"129","author":"Sokou","year":"2022","journal-title":"Placenta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s41390-023-02958-8","article-title":"Assessment of hemostatic profile in neonates with necrotizing enterocolitis using Rotational Thromboelastometry (ROTEM)","volume":"95","author":"Sokou","year":"2023","journal-title":"Pediatr. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00277-023-05144-2","article-title":"Neonatal hematological parameters: The translational aspect of developmental hematopoiesis","volume":"102","author":"Sokou","year":"2023","journal-title":"Ann. Hematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100951","DOI":"10.1016\/j.blre.2022.100951","article-title":"Fresh frozen plasma transfusion in the neonatal population: A systematic review","volume":"55","author":"Sokou","year":"2022","journal-title":"Blood Rev."},{"key":"ref_29","first-page":"620","article-title":"Bleeding Scoring Systems in Neonates: A Systematic Review","volume":"50","author":"Sokou","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.blre.2023.101157","article-title":"Contemporary tools for evaluation of hemostasis in neonates. Where are we and where are we headed?","volume":"64","author":"Sokou","year":"2024","journal-title":"Blood Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41390-020-0785-x","article-title":"Challenges in developing a consensus definition of neonatal sepsis","volume":"88","author":"McGovern","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sokou, R., Ioakeimidis, G., Piovani, D., Parastatidou, S., Konstantinidi, A., Tsantes, A.G., Lampridou, M., Houhoula, D., Iacovidou, N., and Kokoris, S. (2022). Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.1004727"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2036518","DOI":"10.1001\/jamanetworkopen.2020.36518","article-title":"Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection","volume":"4","author":"Fleiss","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4037\/ajcc2012312","article-title":"A new scoring system for evaluation of multiple organ dysfunction syndrome in premature infants","volume":"21","author":"Cetinkaya","year":"2012","journal-title":"Am. J. Crit. Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"F260","DOI":"10.1136\/archdischild-2012-302443","article-title":"A novel approach to standardised recording of bleeding in a high risk neonatal population","volume":"98","author":"Venkatesh","year":"2013","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/INF.0000000000002530","article-title":"Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study","volume":"39","author":"Warris","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Noni, M., Stathi, A., Vaki, I., Velegraki, A., Zachariadou, L., and Michos, A. (2019). Changing epidemiology of invasive candidiasis in children during a 10-year period. J. Fungi, 5.","DOI":"10.3390\/jof5010019"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/jpids\/piaa152","article-title":"A Cluster of Neonatal Infections Caused by Candida auris at a Large Referral Center in Colombia","volume":"10","year":"2021","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3201\/eid2507.180491","article-title":"Hospital-associated multicenter outbreak of emerging fungus Candida auris, colombia, 2016","volume":"25","author":"Armstrong","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3201\/eid2509.190040","article-title":"Epidemiologic shift in Candidemia driven by Candida auris, South Africa, 2016\u20132017","volume":"25","author":"Mpembe","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Sokou, R., Palioura, A.E., Kopanou Taliaka, P., Konstantinidi, A., Tsantes, A.G., Piovani, D., Tsante, K.A., Gounari, E.A., Iliodromiti, Z., and Boutsikou, T. (2024). Candida auris Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061586"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3945\/ajcn.115.126375","article-title":"Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome","volume":"103","author":"Lemas","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.diagmicrobio.2006.01.016","article-title":"Candidemia in pediatric patients with congenital heart disease","volume":"55","author":"Cobo","year":"2006","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/1469-0691.12040","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: Prevention and management of invasive infections in neonates and children caused by Candida spp.","volume":"18","author":"Hope","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/myc.12792","article-title":"Candidemia in children: Epidemiology, prevention and management","volume":"61","author":"Mantadakis","year":"2018","journal-title":"Mycoses"},{"key":"ref_46","first-page":"28","article-title":"Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines","volume":"4","author":"Vasileiou","year":"2018","journal-title":"Curr. Med. Mycol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1093\/jpids\/piy009","article-title":"Neonatal and pediatric candidemia: Results from population-based active laboratory surveillance in four US locations, 2009\u20132015","volume":"7","author":"Benedict","year":"2018","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hsu, J.F., Lai, M.Y., Lee, C.W., Chu, S.M., Wu, I.H., Huang, H.R., Lee, I.T., Chiang, M.C., Fu, R.H., and Tsai, M.H. (2018). Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3100-2"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., Sae-Tia, S., and Fries, B.C. (2020). Candidiasis and mechanisms of antifungal resistance. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060312"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105285","DOI":"10.1016\/j.micpath.2021.105285","article-title":"Dissemination of Candida auris to deep organs in neonatal murine invasive candidiasis","volume":"161","author":"Andrade","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mpakosi, A., Cholevas, V., Meletiadis, J., Theodoraki, M., and Sokou, R. (2024). Neonatal Fungemia by Non-Candida Rare Opportunistic Yeasts: A Systematic Review of Literature. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179266"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/1389203720666190722152415","article-title":"Virulence Factors in Candida species","volume":"21","author":"Staniszewska","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cmi.2019.03.028","article-title":"Resistance of Candida to azoles and echinocandins worldwide","volume":"25","author":"Pristov","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/IDR.S197531","article-title":"Differential recognition of Candida tropicalis, Candida guilliermondii, Candida krusei, and Candida auris by human innate immune cells","volume":"12","author":"Franco","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Garc\u00eda Su\u00e1rez, J., Calumby, R., Silva, D., Barbosa, V., Maranh\u00e3o, F., Moreira, I., Melhem, M., and Moreira, R. (2024). Neonatal innate immunity response in invasive candidiasis. Braz. J. Biol., 84.","DOI":"10.1590\/1519-6984.275155"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Michalski, C., Kan, B., and Lavoie, P.M. (2017). Antifungal Immunological Defenses in Newborns. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00281"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12281-015-0238-x","article-title":"Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface","volume":"9","author":"Arsenault","year":"2015","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Prasad, R. (2017). Host Immune Responses During Infections with Candida albicans. Candida albicans: Cellular and Molecular Biology, Springer International Publishing.","DOI":"10.1007\/978-3-319-50409-4"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Harpf, V., Rambach, G., W\u00fcrzner, R., Lass-Fl\u00f6rl, C., and Speth, C. (2020). Candida and Complement: New Aspects in an Old Battle. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01471"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"109152","DOI":"10.1016\/j.thromres.2024.109152","article-title":"Novel nomogram for the prediction of sepsis-induced coagulopathy in the PICU: A multicentre retrospective study","volume":"243","author":"Gao","year":"2024","journal-title":"Thromb. Res."},{"key":"ref_61","first-page":"696","article-title":"Sepsis-Induced Coagulopathy: A Comprehensive Narrative Review of Pathophysiology, Clinical Presentation, Diagnosis, and Management Strategies","volume":"138","author":"Williams","year":"2024","journal-title":"Anesth. Analg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1378\/chest.128.4.2864","article-title":"Disseminated intravascular coagulation in sepsis","volume":"128","author":"Zeerleder","year":"2005","journal-title":"Chest"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/CCM.0b013e3181eb9d2b","article-title":"Prevalence, management, and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units","volume":"38","author":"Walsh","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jcrc.2018.11.009","article-title":"Epidemiology of disseminated intravascular coagulation in sepsis and validation of scoring systems","volume":"50","author":"Saito","year":"2019","journal-title":"J. Crit. Care"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/00003246-200009001-00003","article-title":"Pathophysiology of disseminated intravascular coagulation in sepsis","volume":"28","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bras, G., Satala, D., Juszczak, M., Kulig, K., Wronowska, E., Bednarek, A., Zawrotniak, M., Rapala-Kozik, M., and Karkowska-Kuleta, J. (2024). Secreted Aspartic Proteinases: Key Factors in Candida Infections and Host-Pathogen Interactions. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094775"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"R82","DOI":"10.1186\/cc2459","article-title":"Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]","volume":"8","author":"Kinasewitz","year":"2004","journal-title":"Crit. Care"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5482\/HAMO-12-05-0011","article-title":"Thromboelastometry guided therapy of severe bleeding. Essener Runde algorithm","volume":"33","author":"Lier","year":"2013","journal-title":"Hamostaseologie"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1590\/s1679-45082017md3130","article-title":"A new era of thromboelastometry","volume":"15","author":"Crochemore","year":"2017","journal-title":"Einstein"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/ijlh.13043","article-title":"Establishing a reference range for thromboelastograph parameters in the neonatal period","volume":"41","author":"Liu","year":"2019","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Theodoraki, M., Sokou, R., Valsami, S., Iliodromiti, Z., Pouliakis, A., Parastatidou, S., Karavana, G., Ioakeimidis, G., Georgiadou, P., and Iacovidou, N. (2020). Reference Values of Thrombolastometry Parameters in Healthy Term Neonates. Children, 7.","DOI":"10.3390\/children7120259"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/MBC.0000000000000585","article-title":"Does whole blood coagulation analysis reflect developmental haemostasis?","volume":"28","author":"Ravn","year":"2017","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"F79","DOI":"10.1136\/archdischild-2016-310545","article-title":"Thromboelastography in term neonates: An alternative approach to evaluating coagulopathy","volume":"102","author":"Sewell","year":"2017","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.earlhumdev.2017.09.014","article-title":"Reference intervals of citrated-native whole blood thromboelastography in premature neonates","volume":"115","author":"Motta","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/bja\/aeq258","article-title":"Thromboelastometry (ROTEM) in children: Age-related reference ranges and correlations with standard coagulation tests","volume":"105","author":"Oswald","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tsantes, A.G., Parastatidou, S., Tsantes, E.A., Bonova, E., Tsante, K.A., Mantzios, P.G., Vaiopoulos, A.G., Tsalas, S., Konstantinidi, A., and Houhoula, D. (2023). Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Life, 13.","DOI":"10.3390\/life13020350"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"G\u00f6rlinger, K., Dirkmann, D., and Albrecht, A. (2016). Rotational Thromboelastometry (ROTEM\u00ae), Springer.","DOI":"10.1007\/978-3-319-28308-1_18"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"136s","DOI":"10.1177\/1076029618797472","article-title":"Rotational Thromboelastometry for Assessing Bleeding Complications and Factor XIII Deficiency in Cardiac Surgery Patients","volume":"24","author":"Besch","year":"2018","journal-title":"Clin. Appl. Thromb.\/Hemost."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"25","DOI":"10.33545\/26643685.2019.v2.i1a.24","article-title":"Study of correlation between thrombocytopenia and fungal sepsis in neonates","volume":"2","author":"Kavthekar","year":"2019","journal-title":"Int. J. Paediatr. Geriatr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"334","DOI":"10.18203\/2349-3291.ijcp20180034","article-title":"Clinical profile of neonatal candidiasis in newborn nursery","volume":"5","author":"James","year":"2018","journal-title":"Int. J. Contemp. Pediatr."},{"key":"ref_81","first-page":"544","article-title":"[Nosocomial Candida infections and thrombocytopenia in very low birth weight newborns]","volume":"67","year":"2007","journal-title":"An. Pediatr."},{"key":"ref_82","first-page":"7","article-title":"Thrombocytopenia as A Predictor of Neonatal Sepsis in Very Low Birth Weight Babies and Its Correlation with Specific Organism Involved: A Hospital Based Observational Study","volume":"3","author":"Ahmad","year":"2015","journal-title":"Indian J. Neonatal Med. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1542\/peds.111.6.1411","article-title":"Platelet count and sepsis in very low birth weight neonates: Is there an organism-specific response?","volume":"111","author":"Guida","year":"2003","journal-title":"Pediatrics"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/09537104.2017.1293810","article-title":"Value of platelet count in the early diagnosis of nosocomial invasive fungal infections in premature infants","volume":"29","author":"Yang","year":"2018","journal-title":"Platelets"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrmicro3269","article-title":"Platelets: At the nexus of antimicrobial defence","volume":"12","author":"Yeaman","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2141.1999.01154.x","article-title":"Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit","volume":"104","author":"Sola","year":"1999","journal-title":"Br. J. Haematol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1651-2227.1999.tb01107.x","article-title":"Circulating thrombopoietin levels in neonates with infection","volume":"88","author":"Colarizi","year":"1999","journal-title":"Acta Paediatr."},{"key":"ref_88","first-page":"w14281","article-title":"Common invasive fungal diseases: An overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia","volume":"146","author":"Schmiedel","year":"2016","journal-title":"Swiss Med. Wkly."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1099\/jmm.0.46121-0","article-title":"Invasive fungal infections are associated with severe depletion of circulating RANTES","volume":"54","author":"Ellis","year":"2005","journal-title":"J. Med. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1258\/acb.2012.011215","article-title":"Activated platelet-derived microparticle numbers are elevated in patients with severe fungal (Candida albicans) sepsis","volume":"49","author":"Woth","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00007890-200001150-00014","article-title":"Thrombocytopenia in liver transplant recipients: Predictors, impact on fungal infections, and role of endogenous thrombopoietin","volume":"69","author":"Chang","year":"2000","journal-title":"Transplantation"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/jth.13267","article-title":"Increased susceptibility to infections before the diagnosis of immune thrombocytopenia","volume":"14","author":"Ekstrand","year":"2016","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_93","first-page":"97","article-title":"Binding and activation of the human plasma kinin-forming system on the cell walls of Candida albicans and Candida tropicalis","volume":"391","author":"Kozik","year":"2010","journal-title":"Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1574-6968.1994.tb07121.x","article-title":"Activation of blood clotting factors by microbial proteinases","volume":"121","author":"Kaminishi","year":"1994","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Renn\u00e9, T., and Stavrou, E.X. (2019). Roles of Factor XII in Innate Immunity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02011"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/rth2.12217","article-title":"The contact pathway and sepsis","volume":"3","author":"Raghunathan","year":"2019","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/oxfordjournals.jbchem.a134892","article-title":"Pathogenesis of serratial infection: Activation of the Hageman factor-prekallikrein cascade by serratial protease","volume":"96","author":"Matsumoto","year":"1984","journal-title":"J. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/jth.13005","article-title":"Factor XI and contact activation as targets for antithrombotic therapy","volume":"13","author":"Gailani","year":"2015","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100582","DOI":"10.1016\/j.blre.2019.05.006","article-title":"The central role of thrombin in bleeding disorders","volume":"38","author":"Negrier","year":"2019","journal-title":"Blood Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.12991\/mpj.2015198611","article-title":"Candida albicans effects the tissue factor activity of blood cells in Type II Diabetes Mellitus","volume":"1","year":"2015","journal-title":"Marmara Pharm. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_102","first-page":"27","article-title":"Association and Outcome of Intracranial Haemorrhage in Newborn with Fungal Sepsis\u2014A Prospective Cohort Study","volume":"10","author":"Adalarasan","year":"2022","journal-title":"Indian J. Neonatal Med. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.thromres.2020.05.028","article-title":"ROTEM diagnostic capacity for measuring fibrinolysis in neonatal sepsis","volume":"192","author":"Lampridou","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/ijlh.14165","article-title":"Thromboelastometry and prediction of in-hospital mortality in neonates with sepsis","volume":"46","author":"Sokou","year":"2024","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0b013e318204bff6","article-title":"Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: A cohort study","volume":"35","author":"Adamzik","year":"2011","journal-title":"Shock"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"317.e1","DOI":"10.1016\/j.jcrc.2012.09.003","article-title":"Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: A prospective study","volume":"28","author":"Ostrowski","year":"2013","journal-title":"J. Crit. Care"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12959-024-00641-4","article-title":"Coagulation dysfunction events associated with echinocandins: A real-world study from FDA adverse event reporting system (FAERS) database","volume":"22","author":"Cheng","year":"2024","journal-title":"Thromb. J."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/1\/17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:56:18Z","timestamp":1760115378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/1\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":107,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jof11010017"],"URL":"https:\/\/doi.org\/10.3390\/jof11010017","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}