{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:18:39Z","timestamp":1793506719745,"version":"4.5.0"},"reference-count":350,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health (NIH)","award":["AI173611"],"award-info":[{"award-number":["AI173611"]}]},{"name":"National Institutes of Health (NIH)","award":["AI177099"],"award-info":[{"award-number":["AI177099"]}]},{"name":"National Institutes of Health (NIH)","award":["AI171817"],"award-info":[{"award-number":["AI171817"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Biofilms are structurally organized communities of microorganisms that adhere to a variety of surfaces. These communities produce protective matrices consisting of polymeric polysaccharides, proteins, nucleic acids, and\/or lipids that promote shared resistance to various environmental threats, including chemical, antibiotic, and immune insults. While algal and bacterial biofilms are more apparent in the scientific zeitgeist, many fungal pathogens also form biofilms. These surprisingly common biofilms are morphologically distinct from the multicellular molds and mushrooms normally associated with fungi and are instead an assemblage of single-celled organisms. As a collection of yeast and filamentous cells cloaked in an extracellular matrix, fungal biofilms are an extreme threat to public health, especially in conjunction with surgical implants. The encapsulated yeast, Cryptococcus neoformans, is an opportunistic pathogen that causes both pulmonary and disseminated infections, particularly in immunocompromised individuals. However, there is an emerging trend of cryptococcosis among otherwise healthy individuals. C. neoformans forms biofilms in diverse environments, including within human hosts. Notably, biofilm association correlates with increased expression of multiple virulence factors and increased resistance to both host defenses and antifungal treatments. Thus, it is crucial to develop novel strategies to combat fungal biofilms. In this review, we discuss the development and treatment of fungal biofilms, with a particular focus on C. neoformans.<\/jats:p>","DOI":"10.3390\/jof11030236","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:48:37Z","timestamp":1742370517000},"page":"236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Hidden Fortress: A Comprehensive Review of Fungal Biofilms with Emphasis on Cryptococcus neoformans"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5521-1231","authenticated-orcid":false,"given":"Hope M.","family":"Pruitt","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-4540","authenticated-orcid":false,"given":"Sean P.","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1139\/m81-143","article-title":"Observations of fouling biofilm formation","volume":"27","author":"McCoy","year":"1981","journal-title":"Can. J. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.mi.39.100185.002523","article-title":"The influence of environment on envelope properties affecting survival of bacteria in infections","volume":"39","author":"Brown","year":"1985","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/apm.12686","article-title":"A short history of microbial biofilms and biofilm infections","volume":"125","year":"2017","journal-title":"APMIS"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Fanning, S., and Mitchell, A.P. (2012). Fungal Biofilms. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002585"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Liu, S., Le Mauff, F., Sheppard, D.C., and Zhang, S. (2022). Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus fumigatus. NPJ Biofilms Microbiomes, 8.","DOI":"10.1038\/s41522-022-00347-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: Survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.13031\/2013.30080","article-title":"Biofilm Accumulation and Structure in the Flow Path of Drip Emitters Using Reclaimed Wastewater","volume":"53","author":"Yan","year":"2010","journal-title":"Trans. ASABE"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/bit.260440510","article-title":"Liquid flow in heterogeneous biofilms","volume":"44","author":"Stoodley","year":"1994","journal-title":"Biotechnol. Bioeng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1128\/IAI.73.10.6350-6362.2005","article-title":"Specific antibody can prevent fungal biofilm formation and this effect correlates with protective efficacy","volume":"73","author":"Martinez","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: Microbial life on surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/microbiolspec.MB-0006-2014","article-title":"Biofilm Formation by Cryptococcus neoformans","volume":"3","author":"Martinez","year":"2015","journal-title":"Microbiol. Spectr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35101627","article-title":"Gene expression in Pseudomonas aeruginosa biofilms","volume":"413","author":"Whiteley","year":"2001","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1128\/EC.4.9.1562-1573.2005","article-title":"Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans","volume":"4","author":"Murillo","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","article-title":"Bacterial biofilm and associated infections","volume":"81","author":"Jamal","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12281-010-0035-5","article-title":"Fungal Biofilms: Relevance in the Setting of Human Disease","volume":"4","author":"Martinez","year":"2010","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1128\/JB.183.18.5385-5394.2001","article-title":"Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance","volume":"183","author":"Chandra","year":"2001","journal-title":"J. Bacteriol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Morelli, K.A., Kerkaert, J.D., and Cramer, R.A. (2021). Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009794"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/13693780701225767","article-title":"Biofilm development by clinical isolates of Malassezia pachydermatis","volume":"45","author":"Cannizzo","year":"2007","journal-title":"Med. Mycol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.riam.2017.02.008","article-title":"Biofilm formation and antifungal susceptibility of Trichosporon asahii isolates from Mexican patients","volume":"35","author":"Montoya","year":"2018","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sav, H., Rafati, H., \u00d6z, Y., Dalyan-Cilo, B., Ener, B., Mohammadi, F., Ilkit, M., van Diepeningen, A.D., and Seyedmousavi, S. (2018). Biofilm Formation and Resistance to Fungicides in Clinically Relevant Members of the Fungal Genus Fusarium. J. Fungi, 4.","DOI":"10.3390\/jof4010016"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Malinovsk\u00e1, Z., \u010conkov\u00e1, E., and V\u00e1czi, P. (2023). Biofilm Formation in Medically Important Candida Species. J. Fungi, 9.","DOI":"10.3390\/jof9100955"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3201\/eid0804.010103","article-title":"Biofilm on ventriculo-peritoneal shunt tubing as a cause of treatment failure in coccidioidal meningitis","volume":"8","author":"Davis","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1128\/AAC.00556-06","article-title":"Biofilm formation by the emerging fungal pathogen Trichosporon asahii: Development, architecture, and antifungal resistance","volume":"50","author":"Pompilio","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1128\/AAC.45.9.2475-2479.2001","article-title":"Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms","volume":"45","author":"Ramage","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Iturrieta-Gonz\u00e1lez, I.A., Padovan, A.C.B., Bizerra, F.C., Hahn, R.C., and Colombo, A.L. (2014). Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109553"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1128\/AAC.50.3.1021-1033.2006","article-title":"Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro","volume":"50","author":"Martinez","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/pr401075f","article-title":"Proteomic profile of Cryptococcus neoformans biofilm reveals changes in metabolic processes","volume":"13","author":"Santi","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Costa, P.d.S., Prado, A., Bagon, N.P., Negri, M., and Svidzinski, T.I.E. (2022). Mixed Fungal Biofilms: From Mycobiota to Devices, a New Challenge on Clinical Practice. Microorganisms, 10.","DOI":"10.3390\/microorganisms10091721"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/1365-2435.13947","article-title":"The significance of biofilms to human, animal, plant and ecosystem health","volume":"36","author":"Sentenac","year":"2022","journal-title":"Funct. Ecol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Corte, L., Roscini, L., Colabella, C., Tascini, C., Leonildi, A., Sozio, E., Menichetti, F., Merelli, M., Scarparo, C., and Meyer, W. (2016). Exploring ecological modelling to investigate factors governing the colonization success in nosocomial environment of Candida albicans and other pathogenic yeasts. Sci. Rep., 6.","DOI":"10.1038\/srep26860"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.micinf.2016.01.002","article-title":"Candida albicans biofilms: Development, regulation, and molecular mechanisms","volume":"18","author":"Gulati","year":"2016","journal-title":"Microbes Infect."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhang, R., Wiederhold, N., Calderone, R., and Li, D. (2024). Biofilm Formation in Clinical Isolates of Fusarium. J. Fungi, 10.","DOI":"10.3390\/jof10110766"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100720","DOI":"10.1016\/j.onehlt.2024.100720","article-title":"Fungal diversity in the soil Mycobiome: Implications for ONE health","volume":"18","author":"Yiallouris","year":"2024","journal-title":"One Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mib.2017.10.020","article-title":"Fungal interactions with the human host: Exploring the spectrum of symbiosis","volume":"40","author":"Hall","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_35","unstructured":"Prajapati, A.K. (2024). Dimorphic fungi, molds, and mold-like agents of medical importance. Microbes of Medical Importance, Iterative International Publishers, Selfypage Developers Pvt Ltd."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"K\u00f6hler, J.R., Hube, B., Puccia, R., Casadevall, A., and Perfect, J.R. (2017). Fungi that Infect Humans. Microbiol. Spectr.","DOI":"10.1128\/microbiolspec.FUNK-0014-2016"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fox, E.P., Singh-Babak, S.D., Hartooni, N., and Nobile, C.J. (2015). Biofilms and Antifungal Resistance. Antifungals: From Genomics to Resistance and the Development of Novel Agents, Caister Academic Press.","DOI":"10.21775\/9781910190012.04"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yadav, A.N. (2021). Formation, Resistance, and Pathogenicity of Fungal Biofilms: Current Trends and Future Challenges. Recent Trends in Mycological Research, Springer International Publishing. Fungal Biology.","DOI":"10.1007\/978-3-030-60659-6"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bongomin, F., Gago, S., Oladele, R.O., and Denning, D.W. (2017). Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J. Fungi, 3.","DOI":"10.3390\/jof3040057"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1439-0507.1994.tb00418.x","article-title":"One hundred years ago: The history of cryptococcosis in Greifswald. Medical mycology in the nineteenth century","volume":"37","author":"Knoke","year":"1994","journal-title":"Mycoses"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","article-title":"Cryptococcosis","volume":"30","author":"Maziarz","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Aslanyan, L., Sanchez, D.A., Valdebenito, S., Eugenin, E.A., Ramos, R.L., and Martinez, L.R. (2017). The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System. J. Fungi, 3.","DOI":"10.3390\/jof3010010"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1128\/IAI.00507-12","article-title":"Titan cell production enhances the virulence of Cryptococcus neoformans","volume":"80","author":"Crabtree","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/EC.00121-12","article-title":"Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections","volume":"11","author":"Okagaki","year":"2012","journal-title":"Eukaryot. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hommel, B., Mukaremera, L., Cordero, R.J.B., Coelho, C., Desjardins, C.A., Sturny-Lecl\u00e8re, A., Janbon, G., Perfect, J.R., Fraser, J.A., and Casadevall, A. (2018). Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006982"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1128\/IAI.00995-06","article-title":"Cryptococcus neoformans Cells in Biofilms Are Less Susceptible than Planktonic Cells to Antimicrobial Molecules Produced by the Innate Immune System","volume":"74","author":"Martinez","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11046-008-9180-6","article-title":"Biofilm Formation by Cryptococcus neoformans Under Distinct Environmental Conditions","volume":"167","author":"Ravi","year":"2009","journal-title":"Mycopathologia"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Benaducci, T., Sardi, J.d.C.O., Lourencetti, N.M.S., Scorzoni, L., Gullo, F.P., Rossi, S.A., Derissi, J.B., de Azevedo Prata, M.C., Fusco-Almeida, A.M., and Mendes-Giannini, M.J.S. (2016). Virulence of Cryptococcus sp. Biofilms In Vitro and In Vivo using Galleria mellonella as an Alternative Model. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00290"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00248-006-9063-7","article-title":"Microbial exopolymers link predator and prey in a model yeast biofilm system","volume":"52","author":"Joubert","year":"2006","journal-title":"Microb. Ecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3201\/eid1001.030119","article-title":"Fungal Biofilms and Drug Resistance","volume":"10","author":"Falkler","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e00400-13","DOI":"10.1128\/mBio.00400-13","article-title":"Methamphetamine Enhances Cryptococcus neoformans Pulmonary Infection and Dissemination to the Brain","volume":"4","author":"Patel","year":"2013","journal-title":"mBio"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1128\/jcm.28.7.1642-1644.1990","article-title":"Natural habitat of Cryptococcus neoformans var. gattii","volume":"28","author":"Ellis","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"a019760","DOI":"10.1101\/cshperspect.a019760","article-title":"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis","volume":"4","author":"Fraser","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1128\/IAI.00542-09","article-title":"Spores as infectious propagules of Cryptococcus neoformans","volume":"77","author":"Velagapudi","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Elsegeiny, W., Marr, K.A., and Williamson, P.R. (2018). Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00651"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/313757","article-title":"Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America","volume":"30","author":"Saag","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2016.167","article-title":"Cryptococcal meningitis: Epidemiology, immunology, diagnosis and therapy","volume":"13","author":"Williamson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/02681219280000511","article-title":"Isolation of Cryptococcus neoformans var. gattii from an Asian patient in France: Evidence for dormant infection in healthy subjects","volume":"30","author":"Dromer","year":"1992","journal-title":"J. Med. Vet. Mycol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Normile, T.G., Bryan, A.M., and Del Poeta, M. (2020). Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated with Primary Infection and Reactivation of Latent Infection. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.581750"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10156-005-0387-X","article-title":"Granuloma and cryptococcosis","volume":"11","author":"Shibuya","year":"2005","journal-title":"J. Infect. Chemother."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ristow, L.C., and Davis, J.M. (2021). The granuloma in cryptococcal disease. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009342"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nri1255","article-title":"Immunity to fungal infections","volume":"4","author":"Romani","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0891-5520(02)00036-3","article-title":"Cryptococcosis","volume":"16","author":"Perfect","year":"2002","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_64","first-page":"250","article-title":"Factors exacerbating immunodeficiency and antifungal resistance in the treatment of fungal infections","volume":"7","author":"Ikechukwu","year":"2023","journal-title":"Biomed. Diagn. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1542\/peds.107.5.e66","article-title":"Serologic evidence for Cryptococcus neoformans infection in early childhood","volume":"107","author":"Goldman","year":"2001","journal-title":"Pediatrics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1086\/314606","article-title":"Cryptococcosis: Population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons. Cryptococcal Active Surveillance Group","volume":"179","author":"Hajjeh","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/infdis\/jiy602","article-title":"HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts","volume":"219","author":"Tugume","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bratton, E.W., El Husseini, N., Chastain, C.A., Lee, M.S., Poole, C., St\u00fcrmer, T., Juliano, J.J., Weber, D.J., and Perfect, J.R. (2012). Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative\/non-transplant. PLoS ONE, 7.","DOI":"10.1371\/annotation\/a94bc542-6682-4579-a315-57019cef7e0e"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Shi, Z.W., Chen, Y., Ogoke, K.M., Strickland, A.B., and Shi, M. (2022). Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Clinical Studies to Animal Experiments. Microorganisms, 10.","DOI":"10.3390\/microorganisms10122419"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S1473-3099(22)00499-6","article-title":"The global burden of HIV-associated cryptococcal infection in adults in 2020: A modelling analysis","volume":"22","author":"Rajasingham","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_71","unstructured":"Pescador Ruschel, M.A., and Thapa, B. (2024). Cryptococcal Meningitis. StatPearls, StatPearls Publishing."},{"key":"ref_72","first-page":"e21984","article-title":"An Uncommon Presentation of Cryptococcal Meningoencephalitis","volume":"14","author":"Freitas","year":"2022","journal-title":"Cureus"},{"key":"ref_73","unstructured":"(2024, December 15). Guidelines for Diagnosing, Preventing and Managing Cryptococcal Disease Among Adults, Adolescents and Children Living with HIV, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK581832\/."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_75","unstructured":"CDC (2025, January 13). Cryptococcosis. Treatment of Cryptococcosis, Available online: https:\/\/www.cdc.gov\/cryptococcosis\/treatment\/index.html."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrmicro3480","article-title":"Through the wall: Extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi","volume":"13","author":"Brown","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jprot.2013.04.001","article-title":"The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles","volume":"97","author":"Rodrigues","year":"2014","journal-title":"J. Proteom."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Cordero, R.J.B., Camacho, E., and Casadevall, A. (2020). Melanization in Cryptococcus neoformans Requires Complex Regulation. mBio, 11.","DOI":"10.1128\/mBio.03313-19"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e0059122","DOI":"10.1128\/msphere.00591-22","article-title":"Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress","volume":"8","author":"Mattoon","year":"2023","journal-title":"mSphere"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mukaremera, L. (2023). The Cryptococcus wall: A different wall for a unique lifestyle. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011141"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/JB.181.2.444-453.1999","article-title":"A glucan synthase FKS1 homolog in Cryptococcus neoformans is single copy and encodes an essential function","volume":"181","author":"Thompson","year":"1999","journal-title":"J. Bacteriol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1073\/pnas.181331398","article-title":"Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans","volume":"98","author":"Levitz","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.1128\/IAI.73.11.7348-7355.2005","article-title":"Characterization of two novel cryptococcal mannoproteins recognized by immune sera","volume":"73","author":"Biondo","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wiesner, D.L., Specht, C.A., Lee, C.K., Smith, K.D., Mukaremera, L., Lee, S.T., Lee, C.G., Elias, J.A., Nielsen, J.N., and Boulware, D.R. (2015). Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004701"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/EC.2.4.655-663.2003","article-title":"A Yeast under Cover: The Capsule of Cryptococcus neoformans","volume":"2","author":"Bose","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1462-5822.2005.00619.x","article-title":"Cryptococcus neoformans capsular polysaccharide component galactoxylomannan induces apoptosis of human T-cells through activation of caspase-8","volume":"8","author":"Pericolini","year":"2006","journal-title":"Cell Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4049\/jimmunol.0900449","article-title":"Galactoxylomannan-Mediated Immunological Paralysis Results from Specific B Cell Depletion in the Context of Widespread Immune System Damage","volume":"183","author":"Nicola","year":"2009","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"LaRocque-de-Freitas, I.F., Rocha, J.D.B., Nunes, M.P., Oliveira, P.A.V., Nascimento, D.d.O., Freire-de-Lima, L., Takiya, C.M., Morrot, A., Decote-Ricardo, D., and Previato, J.O. (2018). Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-34649-4"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1462-5822.2008.01125.x","article-title":"Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand","volume":"10","author":"Villena","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-2164(09)01204-0","article-title":"The capsule of the fungal pathogen Cryptococcus neoformans","volume":"68","author":"Zaragoza","year":"2009","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0008-6215(00)90846-2","article-title":"Structure determination of Cryptococcus neoformans serotype A-variant glucuronoxylomannan by 13C-n.m.r. spectroscopy","volume":"172","author":"Cherniak","year":"1988","journal-title":"Carbohydr. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.carres.2009.03.003","article-title":"The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid","volume":"344","author":"Heiss","year":"2009","journal-title":"Carbohydr. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/EC.00162-07","article-title":"Capsule Structural Heterogeneity and Antigenic Variation in Cryptococcus neoformans","volume":"6","author":"McFadden","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1128\/iai.57.10.3240-3242.1989","article-title":"Antigenic variation within serotypes of Cryptococcus neoformans detected by monoclonal antibodies specific for the capsular polysaccharide","volume":"57","author":"Spiropulu","year":"1989","journal-title":"Infect. Immun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1286-4579(02)00006-0","article-title":"Phenotypic switching in Cryptococcus neoformans","volume":"4","author":"Fries","year":"2002","journal-title":"Microbes Infect."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1590\/S1517-83822007000400015","article-title":"Differences in the cell wall architecture of melanin lacking and melanin producing Cryptococcus neoformans clinical isolates from India: An electron microscopic study","volume":"38","author":"Mandal","year":"2007","journal-title":"Braz. J. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/21505594.2018.1431087","article-title":"The capsule of Cryptococcus neoformans","volume":"10","author":"Casadevall","year":"2018","journal-title":"Virulence"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2958.2003.03957.x","article-title":"Molecular architecture of the Cryptococcus neoformans capsule","volume":"52","author":"Gates","year":"2004","journal-title":"Mol. Microbiol."},{"key":"ref_99","first-page":"4912","article-title":"Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence","volume":"14","author":"Chang","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00636177","article-title":"Decreased virulence in stable, acapsular mutants of Cryptococcus neoformans","volume":"79","author":"Fromtling","year":"1982","journal-title":"Mycopathologia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1073\/pnas.052702799","article-title":"Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm","volume":"99","author":"Tucker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00437227","article-title":"Non-specific immunosuppression by Cryptococcus neoformans infection","volume":"86","author":"Blackstock","year":"1984","journal-title":"Mycopathologia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1128\/iai.5.6.896-901.1972","article-title":"Immunological unresponsiveness induced by cryptococcal capsular polysaccharide assayed by the hemolytic plaque technique","volume":"5","author":"Murphy","year":"1972","journal-title":"Infect. Immun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.129.4.1675","article-title":"The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages","volume":"129","author":"Kozel","year":"1982","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/iai.14.1.62-67.1976","article-title":"Inhibition of phagocytosis by cryptococcal polysaccharide: Dissociation of the attachment and ingestion phases of phagocytosis","volume":"14","author":"Kozel","year":"1976","journal-title":"Infect. Immun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2217\/fmb.13.84","article-title":"Elucidating the Immunological Function of the Cryptococcus neoformans Capsule","volume":"8","author":"Vecchiarelli","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/mmy.38.6.407.417","article-title":"Immunoregulation by capsular components of Cryptococcus neoformans","volume":"38","author":"Vecchiarelli","year":"2000","journal-title":"Med. Mycol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1128\/iai.61.12.5067-5077.1993","article-title":"Mobility of human neutrophils in response to Cryptococcus neoformans cells, culture filtrate antigen, and individual components of the antigen","volume":"61","author":"Dong","year":"1993","journal-title":"Infect. Immun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1172\/JCI118466","article-title":"Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis factor receptor loss from the surface of human neutrophils","volume":"97","author":"Dong","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1128\/IAI.70.9.4762-4771.2002","article-title":"Cryptococcal glucuronoxylomannan inhibits adhesion of neutrophils to stimulated endothelium in vitro by affecting both neutrophils and endothelial cells","volume":"70","author":"Ellerbroek","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1462-5822.2004.00384.x","article-title":"Cryptococcal glucuronoxylomannan interferes with neutrophil rolling on the endothelium","volume":"6","author":"Ellerbroek","year":"2004","journal-title":"Cell Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/iai.65.2.557-563.1997","article-title":"Cryptococcal polysaccharides bind to CD18 on human neutrophils","volume":"65","author":"Dong","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"997","DOI":"10.2217\/imt.11.86","article-title":"Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy","volume":"3","author":"Vecchiarelli","year":"2011","journal-title":"Immunotherapy"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/02681219680000041","article-title":"Cryptococcal capsular polysaccharide utilizes an antigen-presenting cell to induce a T-suppressor cell to secrete TsF","volume":"34","author":"Blackstock","year":"1996","journal-title":"J. Med. Vet. Mycol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1046\/j.1365-2567.1997.00357.x","article-title":"Presentation of cryptococcal capsular polysaccharide (GXM) on activated antigen-presenting cells inhibits the T-suppressor response and enhances delayed-type hypersensitivity and survival","volume":"92","author":"Blackstock","year":"1997","journal-title":"Immunology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2174\/1566524054022585","article-title":"The cellular responses induced by the capsular polysaccharide of Cryptococcus neoformans differ depending on the presence or absence of specific protective antibodies","volume":"5","author":"Vecchiarelli","year":"2005","journal-title":"Curr. Mol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2567.2004.01970.x","article-title":"Immunosuppression, interleukin-10 synthesis and apoptosis are induced in rats inoculated with Cryptococcus neoformans glucuronoxylomannan","volume":"113","author":"Chiapello","year":"2004","journal-title":"Immunology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/intimm\/dxn112","article-title":"Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway","volume":"20","author":"Chiapello","year":"2008","journal-title":"Int. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1251\/bpo68","article-title":"Experimental modulation of capsule size in Cryptococcus neoformans","volume":"6","author":"Zaragoza","year":"2004","journal-title":"Biol. Proced. Online"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/CMR.00001-12","article-title":"The Cryptococcus neoformans Capsule: A Sword and a Shield","volume":"25","author":"Alspaugh","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1462-5822.2008.01186.x","article-title":"Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival","volume":"10","author":"Zaragoza","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/infdis\/jit435","article-title":"Cryptococcus neoformans Ex Vivo Capsule Size Is Associated with Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis","volume":"209","author":"Robertson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_123","first-page":"144","article-title":"Activation of the alternative complement pathway by fungal melanins","volume":"9","author":"Rosas","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10471","DOI":"10.1074\/jbc.RA119.008684","article-title":"The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans","volume":"294","author":"Camacho","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1128\/jb.150.3.1414-1421.1982","article-title":"Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice","volume":"150","author":"Polacheck","year":"1982","journal-title":"J. Bacteriol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0378-1097(97)00239-5","article-title":"Melanization affects susceptibility of Cryptococcus neoformans to heat and cold","volume":"153","author":"Rosas","year":"1997","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/aem.60.10.3864-3866.1994","article-title":"Decreased susceptibility of melanized Cryptococcus neoformans to UV light","volume":"60","author":"Wang","year":"1994","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1128\/AAC.38.11.2648","article-title":"Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B","volume":"38","author":"Wang","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1128\/AAC.46.11.3394-3400.2002","article-title":"Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin","volume":"46","author":"Casadevall","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1128\/IAI.72.3.1693-1699.2004","article-title":"CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence","volume":"72","author":"Noverr","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1128\/IAI.73.4.2012-2019.2005","article-title":"Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection","volume":"73","author":"Mednick","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1128\/IAI.67.11.6034-6039.1999","article-title":"Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages","volume":"67","author":"Liu","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/21505594.2019.1614383","article-title":"Basic principles of the virulence of Cryptococcus","volume":"10","author":"Zaragoza","year":"2019","journal-title":"Virulence"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/EC.00252-10","article-title":"Role of Glucose in the Expression of Cryptococcus neoformans Antiphagocytic Protein 1, App1","volume":"10","author":"Williams","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2217\/fmb.14.132","article-title":"Host Immunity to Cryptococcus neoformans","volume":"10","author":"Rohatgi","year":"2015","journal-title":"Future Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/iai.7.2.231-236.1973","article-title":"Growth of Cryptococcus neoformans within human macrophages in vitro","volume":"7","author":"Diamond","year":"1973","journal-title":"Infect. Immun."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Watkins, R.A., Andrews, A., Wynn, C., Barisch, C., King, J.S., and Johnston, S.A. (2018). Cryptococcus neoformans Escape from Dictyostelium Amoeba by Both WASH-Mediated Constitutive Exocytosis and Vomocytosis. Front. Cell. Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00108"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1073\/pnas.261418798","article-title":"Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages","volume":"98","author":"Steenbergen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"May, R.C., and Casadevall, A. (2018). In Fungal Intracellular Pathogenesis, Form Determines Fate. mBio, 9.","DOI":"10.1128\/mBio.02092-18"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Kassaza, K., Wasswa, F., Nielsen, K., and Bazira, J. (2022). Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa. J. Fungi, 8.","DOI":"10.3390\/jof8070734"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1038\/ncomms7741","article-title":"Global analysis of fungal morphology exposes mechanisms of host cell escape","volume":"6","author":"Veri","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Casadevall, A., Coelho, C., and Alanio, A. (2018). Mechanisms of Cryptococcus neoformans-Mediated Host Damage. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00855"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cub.2006.09.061","article-title":"Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages","volume":"16","author":"Alvarez","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cub.2006.09.032","article-title":"Expulsion of live pathogenic yeast by macrophages","volume":"16","author":"Ma","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Johnston, S.A., and May, R.C. (2010). The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2\/3 complex-mediated actin polymerisation. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001041"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"104731","DOI":"10.1016\/j.meegid.2021.104731","article-title":"Cryptococcus neoformans: Sex, morphogenesis, and virulence","volume":"89","author":"Zhao","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Zaragoza, O. (2011). Multiple Disguises for the Same Party: The Concepts of Morphogenesis and Phenotypic Variations in Cryptococcus neoformans. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00181"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Okagaki, L.H., Strain, A.K., Nielsen, J.N., Charlier, C., Baltes, N.J., Chr\u00e9tien, F., Heitman, J., Dromer, F., and Nielsen, K. (2010). Cryptococcal cell morphology affects host cell interactions and pathogenicity. PLoS Pathog., 6.","DOI":"10.1371\/annotation\/1b59fd9e-9ac9-4ea8-a083-14c413c80b03"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zaragoza, O., Garc\u00eda-Rodas, R., Nosanchuk, J.D., Cuenca-Estrella, M., Rodr\u00edguez-Tudela, J.L., and Casadevall, A. (2010). Fungal cell gigantism during mammalian infection. PLoS Pathog., 6.","DOI":"10.1371\/annotation\/0675044c-d80f-456f-bb63-4f85fb1d0c33"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/jcm.22.6.1068-1070.1985","article-title":"Large Cryptococcus neoformans isolated from brain abscess","volume":"22","author":"Love","year":"1985","journal-title":"J. Clin. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/am.25.2.309-312.1973","article-title":"Cryptococcus neoformans of unusual morphology","volume":"25","author":"Cruickshank","year":"1973","journal-title":"Appl. Microbiol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Rodas, R., Casadevall, A., Rodr\u00edguez-Tudela, J.L., Cuenca-Estrella, M., and Zaragoza, O. (2011). Cryptococcus neoformans capsular enlargement and cellular gigantism during Galleria mellonella infection. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024485"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1128\/MCB.21.9.3179-3191.2001","article-title":"Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans","volume":"21","author":"Alspaugh","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1128\/AAC.00545-06","article-title":"Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds","volume":"50","author":"Nosanchuk","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02876784","article-title":"Growth of Cryptococcus neoformans in UV-irradiated excreta of pigeons","volume":"20","year":"1975","journal-title":"Folia Microbiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/00362177985380341","article-title":"Cryptococcus neoformans: Gastronomic delight of a soil ameba","volume":"17","author":"Bunting","year":"1979","journal-title":"Sabouraudia"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/00362178285380051","article-title":"Control of Cryptococcus neoformans in nature by biotic factors","volume":"20","author":"Ruiz","year":"1982","journal-title":"Sabouraudia"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/ijd.13116","article-title":"Malassezia species in healthy skin and in dermatological conditions","volume":"55","author":"Prohic","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Yin, W., Wang, Y., Liu, L., and He, J. (2019). Biofilms: The Microbial \u201cProtective Clothing\u201d in Extreme Environments. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143423"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrmicro821","article-title":"Bacterial biofilms: From the natural environment to infectious diseases","volume":"2","author":"Costerton","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_161","first-page":"373","article-title":"Ventriculoatrial shunt infection due to Cryptococcus neoformans: An ultrastructural and quantitative microbiological study","volume":"18","author":"Walsh","year":"1986","journal-title":"Neurosurgery"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/02681219780001031","article-title":"A case of prosthetic valve endocarditis caused by Cryptococcus neoformans var. neoformans","volume":"35","author":"Banerjee","year":"1997","journal-title":"J. Med. Vet. Mycol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Lopes, W., Vainstein, M.H., De Sousa Araujo, G.R., Frases, S., Staats, C.C., de Almeida, R.M.C., Schrank, A., Kmetzsch, L., and Vainstein, M.H. (2017). Geometrical Distribution of Cryptococcus neoformans Mediates Flower-Like Biofilm Development. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.02534"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0272-6386(12)80683-4","article-title":"Cryptococcal infection of a prosthetic dialysis fistula","volume":"24","author":"Braun","year":"1994","journal-title":"Am. J. Kidney Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.diagmicrobio.2009.01.005","article-title":"Prosthetic hip infection due to Cryptococcus neoformans: Case report","volume":"64","author":"Johannsson","year":"2009","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11046-014-9847-0","article-title":"Cryptococcus neoformans prosthetic joint infection: Case report and review of the literature","volume":"179","author":"Shah","year":"2015","journal-title":"Mycopathologia"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/EC.00242-12","article-title":"Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases","volume":"11","author":"Lee","year":"2012","journal-title":"Eukaryot. Cell"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mib.2015.06.003","article-title":"The morphotype heterogeneity in Cryptococcus neoformans","volume":"26","author":"Wang","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Wang, L., Zhai, B., and Lin, X. (2012). The Link between Morphotype Transition and Virulence in Cryptococcus neoformans. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002765"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"11571","DOI":"10.1073\/pnas.1308173110","article-title":"Fungal adhesion protein guides community behaviors and autoinduction in a paracrine manner","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","unstructured":"Mittelman, M.W. (1996). Adhesion to Biomaterials. Bacterial Adhesion: Molecular and Ecological Diversity, Wiley-Liss."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1128\/AEM.02506-06","article-title":"Cryptococcus neoformans biofilm formation depends on surface support and carbon source and reduces fungal cell susceptibility to heat, cold, and UV light","volume":"73","author":"Martinez","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.biomaterials.2009.09.087","article-title":"The use of chitosan to damage Cryptococcus neoformans biofilms","volume":"31","author":"Martinez","year":"2010","journal-title":"Biomaterials"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e00986-13","DOI":"10.1128\/mBio.00986-13","article-title":"Quorum Sensing-Mediated, Cell Density-Dependent Regulation of Growth and Virulence in Cryptococcus neoformans","volume":"5","author":"Albuquerque","year":"2014","journal-title":"mBio"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1128\/EC.00111-14","article-title":"Interaction of Cryptococcus neoformans Extracellular Vesicles with the Cell Wall","volume":"13","author":"Wolf","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/femsre\/fuy022","article-title":"Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis","volume":"42","author":"Barriuso","year":"2018","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.coph.2013.07.003","article-title":"Quo vadis quorum quenching?","volume":"13","author":"Zhu","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Weiland-Br\u00e4uer, N., Malek, I., and Schmitz, R.A. (2019). Metagenomic quorum quenching enzymes affect biofilm formation of Candida albicans and Staphylococcus epidermidis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211366"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Park, J., Park, H., Jang, J.-U., Kim, H., Park, H., Iqbal, T., Oh, H.-S., Choo, K.-H., and Lee, K. (2024). Benefits of fungal-to-bacterial quorum quenching as anti-biofouling strategy in membrane bioreactors for wastewater treatment and water reuse. Bioresour. Technol., 403.","DOI":"10.1016\/j.biortech.2024.130848"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e01751-17","DOI":"10.1128\/AAC.01751-17","article-title":"Roles of Three Cryptococcus neoformans and Cryptococcus gattii Efflux Pump-Coding Genes in Response to Drug Treatment","volume":"62","author":"Chang","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02010441","article-title":"Microbial film development in a trickling filter","volume":"2","author":"Mack","year":"1975","journal-title":"Microb. Ecol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12934-016-0569-5","article-title":"Living together in biofilms: The microbial cell factory and its biotechnological implications","volume":"15","author":"Berlanga","year":"2016","journal-title":"Microb. Cell Factories"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2019.04.001","article-title":"Candida albicans biofilm growth and dispersal: Contributions to pathogenesis","volume":"52","author":"Wall","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/21655979.2021.1996747","article-title":"Regulatory network controls microbial biofilm development, with Candida albicans as a representative: From adhesion to dispersal","volume":"13","author":"Xu","year":"2022","journal-title":"Bioengineered"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.chom.2023.12.012","article-title":"Fungicide-tolerant persister formation during cryptococcal pulmonary infection","volume":"32","author":"Ke","year":"2024","journal-title":"Cell Host Microbe"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1128\/AAC.00684-06","article-title":"Candida albicans biofilms produce antifungal-tolerant persister cells","volume":"50","author":"LaFleur","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","article-title":"Riddle of Biofilm Resistance","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijantimicag.2013.10.023","article-title":"Strength in numbers: Antifungal strategies against fungal biofilms","volume":"43","author":"Ramage","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"a019679","DOI":"10.1101\/cshperspect.a019679","article-title":"Fungal Morphogenesis","volume":"5","author":"Lin","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1080\/21505594.2015.1066962","article-title":"Fungal serotype-specific differences in bacterial-yeast interactions","volume":"6","author":"Abdulkareem","year":"2015","journal-title":"Virulence"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mmcr.2014.08.003","article-title":"Central nervous system cryptococcoma in a Ugandan patient with Human Immunodeficiency Virus","volume":"6","author":"Velamakanni","year":"2014","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"bcr2016218824","DOI":"10.1136\/bcr-2016-218824","article-title":"Cerebral cryptococcoma mimicking glioblastoma","volume":"2017","author":"Ulett","year":"2017","journal-title":"BMJ Case Rep."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Chastain, D.B., Rao, A., Yaseyyedi, A., Henao-Mart\u00ednez, A.F., Borges, T., and Franco-Paredes, C. (2022). Cerebral Cryptococcomas: A Systematic Scoping Review of Available Evidence to Facilitate Diagnosis and Treatment. Pathogens, 11.","DOI":"10.3390\/pathogens11020205"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1130-1406(08)70051-2","article-title":"Hallazgos en las im\u00e1genes por resonancia magn\u00e9tica en pacientes con sida y neurocriptococosis","volume":"25","author":"Corti","year":"2008","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ceb.2016.05.005","article-title":"Dynamic cell-matrix interactions modulate microbial biofilm and tissue 3D microenvironments","volume":"42","author":"Koo","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"McClelland, E.E. (2024). Measuring Laccase Activity and Melanin Production in Cryptococcus neoformans. Cryptococcus neoformans: Methods and Protocols, Springer US.","DOI":"10.1007\/978-1-0716-3722-7"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrmicro2522","article-title":"Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box","volume":"9","author":"Kronstad","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Hamed, M.F., Ara\u00fajo, G.R.d.S., Munzen, M.E., Reguera-Gomez, M., Epstein, C., Lee, H.H., Frases, S., and Martinez, L.R. (2023). Phospholipase B Is Critical for Cryptococcus neoformans Survival in the Central Nervous System. mBio, 14.","DOI":"10.1128\/mbio.02640-22"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Kietrungruang, K., Sookkree, S., Sangboonruang, S., Semakul, N., Poomanee, W., Kitidee, K., Tragoolpua, Y., and Tragoolpua, K. (2023). Ethanolic Extract Propolis-Loaded Niosomes Diminish Phospholipase B1, Biofilm Formation, and Intracellular Replication of Cryptococcus neoformans in Macrophages. Molecules, 28.","DOI":"10.3390\/molecules28176224"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/EC.00287-12","article-title":"Extracellular DNA Release Acts as an Antifungal Resistance Mechanism in Mature Aspergillus fumigatus Biofilms","volume":"12","author":"Rajendran","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"ref_203","first-page":"21","article-title":"The Extracellular Matrix of Fungal Biofilms","volume":"Volume 3","author":"Imbert","year":"2016","journal-title":"Fungal Biofilms and Related Infections: Advances in Microbiology, Infectious Diseases and Public Health"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.295.5559.1487","article-title":"Extracellular DNA required for bacterial biofilm formation","volume":"295","author":"Whitchurch","year":"2002","journal-title":"Science"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/bit.27760","article-title":"The role of extracellular DNA in the formation, architecture, stability, and treatment of bacterial biofilms","volume":"118","author":"Panlilio","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Campoccia, D., Montanaro, L., and Arciola, C.R. (2021). Extracellular DNA (eDNA). A Major Ubiquitous Element of the Bacterial Biofilm Architecture. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22169100"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Ib\u00e1\u00f1ez de Aldecoa, A.L., Zafra, O., and Gonz\u00e1lez-Pastor, J.E. (2017). Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01390"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans","volume":"77","author":"Charlier","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Decote-Ricardo, D., LaRocque-de-Freitas, I.F., Rocha, J.D.B., Nascimento, D.O., Nunes, M.P., Morrot, A., Freire-de-Lima, L., Previato, J.O., Mendon\u00e7a-Previato, L., and Freire-de-Lima, C.G. (2019). Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans. Front. Med., 6.","DOI":"10.3389\/fmed.2019.00129"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/j.1462-5822.2008.01152.x","article-title":"Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation","volume":"10","author":"Alvarez","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_211","first-page":"64","article-title":"MRI findings of intramedullary spinal cryptococcoma","volume":"13","author":"Ercan","year":"2007","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Trevijano-Contador, N., de Oliveira, H.C., Garc\u00eda-Rodas, R., Rossi, S.A., Llorente, I., Zaballos, \u00c1., Janbon, G., Ari\u00f1o, J., and Zaragoza, \u00d3. (2018). Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007007"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Dambuza, I.M., Drake, T., Chapuis, A., Zhou, X., Correia, J., Taylor-Smith, L., LeGrave, N., Rasmussen, T., Fisher, M.C., and Bicanic, T. (2018). The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006978"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e02549-23","DOI":"10.1128\/mbio.02549-23","article-title":"Accumulation of endogenous free radicals is required to induce titan-like cell formation in Cryptococcus neoformans","volume":"15","author":"Sachse","year":"2024","journal-title":"mBio"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Caza, M., and Kronstad, J.W. (2019). The cAMP\/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans. Front. Cell. Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00212"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e01537-17","DOI":"10.1128\/mBio.01537-17","article-title":"Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans","volume":"8","author":"Mayer","year":"2017","journal-title":"mBio"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1128\/MMBR.00045-10","article-title":"Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease","volume":"75","author":"Shapiro","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Yang, C., Huang, Y., Zhou, Y., Zang, X., Deng, H., Liu, Y., Shen, D., and Xue, X. (2022). Cryptococcus escapes host immunity: What do we know?. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1041036"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/AEM.02846-08","article-title":"Antibody-mediated immobilization of Cryptococcus neoformans promotes biofilm formation","volume":"75","author":"Robertson","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Nett, J.E., and Andes, D. (2015). Fungal Biofilms: In vivo models for discovery of anti-biofilm drugs. Microbiol. Spectr., 3.","DOI":"10.1128\/microbiolspec.MB-0008-2014"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Garvey, M., and Rowan, N.J. (2023). Pathogenic Drug Resistant Fungi: A Review of Mitigation Strategies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021584"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/CMR.17.2.255-267.2004","article-title":"Candida infections of medical devices","volume":"17","author":"Kojic","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/cid\/cis021","article-title":"Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: A patient-level quantitative review of randomized trials","volume":"54","author":"Andes","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1128\/IAI.72.9.4985-4995.2004","article-title":"Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier","volume":"72","author":"Chang","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/infdis\/jit117","article-title":"Methamphetamine alters blood brain barrier protein expression in mice, facilitating central nervous system infection by neurotropic Cryptococcus neoformans","volume":"208","author":"Eugenin","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5507\/bp.2009.031","article-title":"Hypoxia sensing in Cryptococcus neoformans: Biofilm-like adaptation for dormancy?","volume":"153","author":"Moranova","year":"2009","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech Repub."},{"key":"ref_227","first-page":"211","article-title":"Fungi pathogenic to humans: Molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus","volume":"56","author":"Kozik","year":"2009","journal-title":"Acta Biochim. Pol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Qian, W., Li, X., Liu, Q., Lu, J., Wang, T., and Zhang, Q. (2022). Antifungal and Antibiofilm Efficacy of Paeonol Treatment Against Biofilms Comprising Candida albicans and\/or Cryptococcus neoformans. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.884793"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15698\/mic2018.11.656","article-title":"A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans","volume":"5","author":"Mayer","year":"2018","journal-title":"Microb. Cell"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.mib.2011.06.001","article-title":"Mucosal biofilms of Candida albicans","volume":"14","author":"Ganguly","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","article-title":"Candida biofilms and their role in infection","volume":"11","author":"Douglas","year":"2003","journal-title":"Trends Microbiol."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Talapko, J., Juzba\u0161i\u0107, M., Matijevi\u0107, T., Pustijanac, E., Beki\u0107, S., Kotris, I., and \u0160krlec, I. (2021). Candida albicans-The Virulence Factors and Clinical Manifestations of Infection. J. Fungi, 7.","DOI":"10.3390\/jof7020079"},{"key":"ref_233","unstructured":"R, A.N., and Rafiq, N.B. (2025). Candidiasis. StatPearls, StatPearls Publishing."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.21608\/nrmj.2024.334881.1785","article-title":"A comprehensive literature review on the oral microbiota: Key concepts and implications for dental and systemic health","volume":"8","author":"Benabderrahmane","year":"2024","journal-title":"Nov. Res. Microbiol. J."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","article-title":"Candida albicans Biofilms and Human Disease","volume":"69","author":"Nobile","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/archinte.1988.00380120094019","article-title":"Hospital-acquired candidemia. The attributable mortality and excess length of stay","volume":"148","author":"Wey","year":"1988","journal-title":"Arch. Intern. Med."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1073\/pnas.1318690111","article-title":"Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Latg\u00e9, J.-P., and Steinbach, W.J. (2014). A Perspective on Aspergillus fumigatus Research for the Next Ten Years. Aspergillus fumigatus and Aspergillosis, ASM Press.","DOI":"10.1128\/9781555815523.ch41"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.1302235","article-title":"Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils","volume":"192","author":"Taylor","year":"2014","journal-title":"J. Immunol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/jop.2012.0155","article-title":"In vitro antifungal activity of silver nanoparticles against ocular pathogenic filamentous fungi","volume":"29","author":"Xu","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1364-3703.2007.00436.x","article-title":"Aspergillus flavus: The major producer of aflatoxin","volume":"8","author":"Klich","year":"2007","journal-title":"Mol. Plant Pathol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1128\/microbiolspec.MB-0017-2015","article-title":"Aspergillus Biofilm In Vitro and In Vivo","volume":"3","author":"Beauvais","year":"2015","journal-title":"Microbiol. Spectr."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Alkhalifah, D.H.M., Damra, E., Khalaf, S.M.H., and Hozzein, W.N. (2022). Biogeography of Black Mold Aspergillus niger: Global Situation and Future Perspective under Several Climate Change Scenarios Using MaxEnt Modeling. Diversity, 14.","DOI":"10.3390\/d14100845"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Lass-Fl\u00f6rl, C., Dietl, A.-M., Kontoyiannis, D.P., and Brock, M. (2021). Aspergillus terreus Species Complex. Clin. Microbiol. Rev., 34.","DOI":"10.1128\/CMR.00311-20"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1086\/344058","article-title":"Antifungal resistance in pathogenic fungi","volume":"35","author":"Perea","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"22473","DOI":"10.1073\/pnas.2003700117","article-title":"Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance","volume":"117","author":"Kowalski","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1128\/AAC.00234-08","article-title":"Aspergillus fumigatus forms biofilms with reduced antifungal drug susceptibility on bronchial epithelial cells","volume":"52","author":"Seidler","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1462-5822.2009.01409.x","article-title":"In vivo biofilm composition of Aspergillus fumigatus","volume":"12","author":"Loussert","year":"2010","journal-title":"Cell Microbiol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.3109\/13693786.2010.502190","article-title":"Aspergillus fumigatus biofilms in the clinical setting","volume":"49","author":"Seidler","year":"2011","journal-title":"Med. Mycol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1574-6968.2011.02381.x","article-title":"Aspergillus biofilms: Clinical and industrial significance","volume":"324","author":"Ramage","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/5584_2016_4","article-title":"Aspergillus Biofilms in Human Disease","volume":"Volume 931","author":"Imbert","year":"2016","journal-title":"Fungal Biofilms and Related Infections"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/mmy\/myx134","article-title":"Malassezia ecology, pathophysiology, and treatment","volume":"56","author":"Theelen","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/apm.13419","article-title":"In vitro determination of the susceptibility of Malassezia furfur biofilm to different commercially used antimicrobials","volume":"132","author":"Cassola","year":"2024","journal-title":"APMIS"},{"key":"ref_254","first-page":"14","article-title":"Seborrheic Dermatitis and Malassezia species: How Are They Related?","volume":"2","author":"Kim","year":"2009","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_255","first-page":"431","article-title":"Association of Malassezia species with dandruff","volume":"139","author":"Rudramurthy","year":"2014","journal-title":"Indian. J. Med. Res."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Velegraki, A., Cafarchia, C., Gaitanis, G., Iatta, R., and Boekhout, T. (2015). Malassezia infections in humans and animals: Pathophysiology, detection, and treatment. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004523"},{"key":"ref_257","first-page":"e62223","article-title":"Evaluation of the Ability of Malassezia Species in Biofilm Formation","volume":"13","author":"Zareei","year":"2017","journal-title":"Arch. Clin. Infect. Dis."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/mmy\/myx014","article-title":"Biofilm, adherence, and hydrophobicity as virulence factors in Malassezia furfur","volume":"56","author":"Angiolella","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"\u010conkov\u00e1, E., Pro\u0161kovcov\u00e1, M., V\u00e1czi, P., and Malinovsk\u00e1, Z. (2022). In Vitro Biofilm Formation by Malassezia pachydermatis Isolates and Its Susceptibility to Azole Antifungals. J. Fungi, 8.","DOI":"10.3390\/jof8111209"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1469-0691.2001.tb00005.x","article-title":"Uncommon opportunistic fungi: New nosocomial threats","volume":"7","author":"Groll","year":"2001","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1470-9465.2004.00839.x","article-title":"Infections due to emerging and uncommon medically important fungal pathogens","volume":"10","author":"Walsh","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_262","first-page":"21","article-title":"Nosocomial urinary infection due to Trichosporon asahii. First two cases in Chile","volume":"20","author":"Silva","year":"2003","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1439-0507.2001.00614.x","article-title":"Transmission of Trichosporon asahii oesophagitis by a contaminated endoscope","volume":"44","author":"Pernice","year":"2001","journal-title":"Mycoses"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5414\/CNP62066","article-title":"Trichosporon asahii infection of a dialysis PTFE arteriovenous graft","volume":"62","author":"Krzossok","year":"2004","journal-title":"Clin. Nephrol."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Matsumoto, Y., Nakayama, M., Shimizu, Y., Koganesawa, S., Kanai, H., Sugiyama, Y., Kurakado, S., and Sugita, T. (2024). Role of Hog1-mediated stress tolerance in biofilm formation by the pathogenic fungus Trichosporon asahii. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-80200-z"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1099\/jmm.0.000159","article-title":"Trichosporon inkin biofilms produce extracellular proteases and exhibit resistance to antifungals","volume":"64","author":"Serpa","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Cordeiro, R.D.A., Aguiar, A.L.R., da Silva, B.N., Pereira, L.M.G., Portela, F.V.M., de Camargo, Z.P., de Lima-Neto, R.G., de Castelo-Branco, D.S.C.M., Rocha, M.F.G., and Sidrim, J.J.C. (2021). Trichosporon asahii and Trichosporon inkin Biofilms Produce Antifungal-Tolerant Persister Cells. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.645812"},{"key":"ref_268","unstructured":"(2025, January 15). Persister Cell\u2014An Overview|ScienceDirect Topics. Available online: https:\/\/www.sciencedirect.com\/topics\/neuroscience\/persister-cell."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/JCM.00120-06","article-title":"Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment","volume":"44","author":"Zhang","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/mpp.12289","article-title":"The Fusarium solani species complex: Ubiquitous pathogens of agricultural importance","volume":"17","author":"Coleman","year":"2016","journal-title":"Mol. Plant Pathol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0195-6701(97)90197-3","article-title":"Fungaemia due to Fusarium spp. in cancer patients","volume":"36","author":"Krcmery","year":"1997","journal-title":"J. Hosp. Infect."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/CMR.00014-07","article-title":"Fusarium infections in immunocompromised patients","volume":"20","author":"Nucci","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijantimicag.2017.06.017","article-title":"Current antifungal treatment of fusariosis","volume":"51","author":"Bonifaz","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1167\/iovs.09-4237","article-title":"A murine model of contact lens-associated fusarium keratitis","volume":"51","author":"Sun","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.watres.2015.02.036","article-title":"Adaptation of Fusarium oxysporum and Fusarium dimerum to the specific aquatic environment provided by the water systems of hospitals","volume":"76","author":"Steinberg","year":"2015","journal-title":"Water Res."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/ijd.15747","article-title":"Characterization of a biofilm formed by Fusarium oxysporum on the human nails","volume":"61","author":"Veiga","year":"2022","journal-title":"Int. J. Dermatol."},{"key":"ref_277","unstructured":"World Health Organization (2024, December 16). Outbreak of Suspected Fungal Meningitis Associated with Surgical Procedures Performed Under Spinal Anaesthesia\u2014The United States of America and Mexico. Available online: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2023-DON470."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11046-023-00790-6","article-title":"Treatment of Fusarium Infection of the Central Nervous System: A Review of Past Cases to Guide Therapy for the Ongoing 2023 Outbreak in the United States and Mexico","volume":"188","author":"Hoenigl","year":"2023","journal-title":"Mycopathologia"},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Jani\u0107 Hajnal, E., Kos, J., Radi\u0107, B., Ani\u0107, M., Radovi\u0107, R., Kudumija, N., Vuli\u0107, A., \u0110eki\u0107, S., and Pleadin, J. (2023). Impact of Climate Changes on the Natural Prevalence of Fusarium Mycotoxins in Maize Harvested in Serbia and Croatia. Foods, 12.","DOI":"10.3390\/foods12051002"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jgar.2020.12.016","article-title":"Advances in Fusarium drug resistance research","volume":"24","author":"Zhao","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Tejeda-Garibay, S., and Hoyer, K.K. (2023). Coccidioidomycosis and Host Microbiome Interactions: What We Know and What We Can Infer from Other Respiratory Infections. J. Fungi, 9.","DOI":"10.3390\/jof9050586"},{"key":"ref_282","first-page":"e50260","article-title":"Valley Fever: Pathogenesis and Evolving Treatment Options","volume":"15","author":"Zaheri","year":"2023","journal-title":"Cureus"},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Kirkland, T.N., Stevens, D.A., Hung, C.-Y., Beyhan, S., Taylor, J.W., Shubitz, L.F., Duttke, S.H., Heidari, A., Johnson, R.H., and Deresinski, S.C. (2022). Coccidioides Species: A Review of Basic Research: 2022. J. Fungi, 8.","DOI":"10.3390\/jof8080859"},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Diep, A.L., and Hoyer, K.K. (2020). Host Response to Coccidioides Infection: Fungal Immunity. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.581101"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/JCM.01776-06","article-title":"Detection of Coccidioides species in clinical specimens by real-time PCR","volume":"45","author":"Binnicker","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.riam.2013.09.014","article-title":"Highlights in pathogenic fungal biofilms","volume":"31","author":"Sardi","year":"2014","journal-title":"Rev. Iberoam. de Micol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5694\/j.1326-5377.2007.tb01313.x","article-title":"Antifungal agents","volume":"187","author":"Chen","year":"2007","journal-title":"Med. J. Aust."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1073\/pnas.1117280109","article-title":"Amphotericin primarily kills yeast by simply binding ergosterol","volume":"109","author":"Gray","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Mesa-Arango, A.C., Scorzoni, L., and Zaragoza, O. (2012). It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00286"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"e01755-18","DOI":"10.1128\/mBio.01755-18","article-title":"The Multifunctional Fungal Ergosterol","volume":"9","author":"Rodrigues","year":"2018","journal-title":"mBio"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1681\/ASN.V62154","article-title":"Amphotericin B nephrotoxicity: The adverse consequences of altered membrane properties","volume":"6","author":"Sawaya","year":"1995","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2165\/00002018-199005020-00003","article-title":"Amphotericin B Nephrotoxicity","volume":"5","author":"Sabra","year":"1990","journal-title":"Drug Saf."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/1523-1747.ep12521036","article-title":"Mechanisms of action of the antimycotic imidazoles","volume":"76","author":"Sud","year":"1981","journal-title":"J. Investig. Dermatol."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Whaley, S.G., Berkow, E.L., Rybak, J.M., Nishimoto, A.T., Barker, K.S., and Rogers, P.D. (2016). Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.02173"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"e130336","DOI":"10.5812\/ijpr-130336","article-title":"Hepatotoxicity Induced by Azole Antifungal Agents: A Review Study","volume":"22","author":"Rakhshan","year":"2023","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(84)81032-7","article-title":"Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans","volume":"173","author":"Kerridge","year":"1984","journal-title":"FEBS Lett."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jac\/dkf045","article-title":"Echinocandins: A new class of antifungal","volume":"49","author":"Denning","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1128\/AAC.49.7.2851-2856.2005","article-title":"Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins","volume":"49","author":"Maligie","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"S662","DOI":"10.1093\/cid\/civ739","article-title":"Antifungal-Associated Drug-Induced Cardiac Disease","volume":"61","author":"Cleary","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"114874","DOI":"10.1016\/j.addr.2023.114874","article-title":"New antifungal strategies: Drug combination and co-delivery","volume":"198","author":"Zhu","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/ci100403b","article-title":"Detailed mechanism of squalene epoxidase inhibition by terbinafine","volume":"51","author":"Nowosielski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1126\/science.6547247","article-title":"Allylamine Derivatives: New Class of Synthetic Antifungal Agents Inhibiting Fungal Squalene Epoxidase","volume":"224","author":"Petranyi","year":"1984","journal-title":"Science"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11596-007-0228-5","article-title":"Comparison of the effects of three different anti-fungus drugs on Candida albicans of murine vaginal mucosa","volume":"27","author":"Chen","year":"2007","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/cmi.12590","article-title":"Cryptococcal therapies and drug targets: The old, the new and the promising","volume":"18","author":"Coelho","year":"2016","journal-title":"Cell Microbiol."},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Tits, J., Cammue, B.P.A., and Thevissen, K. (2020). Combination Therapy to Treat Fungal Biofilm-Based Infections. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228873"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1128\/AAC.46.6.1773-1780.2002","article-title":"Antifungal susceptibility of Candida biofilms: Unique efficacy of amphotericin B lipid formulations and echinocandins","volume":"46","author":"Kuhn","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_308","first-page":"197","article-title":"In search of the holy grail of antifungal therapy","volume":"119","author":"Chapman","year":"2008","journal-title":"Trans. Am. Clin. Clim. Assoc."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s40475-015-0046-y","article-title":"Cryptococcal Meningitis: Diagnosis and Management Update","volume":"2","author":"Abassi","year":"2015","journal-title":"Curr. Trop. Med. Rep."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Ramage, G., Rajendran, R., Sherry, L., and Williams, C. (2012). Fungal biofilm resistance. Int. J. Microbiol., 2012.","DOI":"10.1155\/2012\/528521"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"106673","DOI":"10.1016\/j.ijantimicag.2022.106673","article-title":"Candida albicans biofilms: Antifungal resistance, immune evasion, and emerging therapeutic strategies","volume":"60","author":"Fan","year":"2022","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_312","first-page":"37","article-title":"Update on the Fungal Biofilm Drug Resistance and Its Alternative Treatment","volume":"4","author":"Tseung","year":"2016","journal-title":"J. Biosci. Med."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/mmi.14565","article-title":"Combatting the evolution of antifungal resistance in Cryptococcus neoformans","volume":"114","author":"Bermas","year":"2020","journal-title":"Mol. Microbiol."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-0757.2009.00338.x","article-title":"Candida biofilms and oral candidosis: Treatment and prevention","volume":"55","author":"Williams","year":"2011","journal-title":"Periodontol. 2000"},{"key":"ref_315","doi-asserted-by":"crossref","unstructured":"Nett, J.E., and Pohl, C.H. (2021). Editorial: Fungal Biofilms in Infection and Disease. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.753650"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/microbiolspec.MB-0007-2014","article-title":"From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms","volume":"3","author":"Pierce","year":"2015","journal-title":"Microbiol. Spectr."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s100960050001","article-title":"Intravascular catheter-associated infections","volume":"19","author":"Crump","year":"2000","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01351-12","article-title":"Antifungal lock therapy","volume":"57","author":"Walraven","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1128\/AAC.50.5.1865-1868.2006","article-title":"Comparative in vitro efficacies of various catheter lock solutions","volume":"50","author":"Sherertz","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/08927014.2011.593261","article-title":"Mini-review: Antimicrobial central venous catheters\u2014Recent advances and strategies","volume":"27","author":"Sousa","year":"2011","journal-title":"Biofouling"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/lam.13653","article-title":"Antifungal lock therapy: An eternal promise or an effective alternative therapeutic approach?","volume":"74","author":"Majoros","year":"2022","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/AAC.48.5.1727-1732.2004","article-title":"Rabbit model of Candida albicans biofilm infection: Liposomal amphotericin B antifungal lock therapy","volume":"48","author":"Schinabeck","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"e00299-19","DOI":"10.1128\/AAC.00299-19","article-title":"Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm","volume":"63","author":"Reitzel","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"101290","DOI":"10.1016\/j.mam.2024.101290","article-title":"Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy","volume":"98","author":"Gupta","year":"2024","journal-title":"Mol. Asp. Med."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clay.2013.04.015","article-title":"Characterization, degradation and biocompatibility of PBAT based nanocomposites","volume":"80\u201381","author":"Fukushima","year":"2013","journal-title":"Appl. Clay Sci."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1094\/PDIS-93-10-1037","article-title":"Antifungal Activity of Silver Ions and Nanoparticles on Phytopathogenic Fungi","volume":"93","author":"Jo","year":"2009","journal-title":"Plant Dis."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Pal, K. (2021). Anti-Biofilm Activities of Nanocomposites: Current Scopes and Limitations. Bio-manufactured Nanomaterials, Springer International Publishing.","DOI":"10.1007\/978-3-030-67223-2"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"100042","DOI":"10.1016\/j.nxsust.2024.100042","article-title":"Novel nanocomposites with advanced materials and their role in waste water treatment","volume":"4","author":"Panigrahy","year":"2024","journal-title":"Next Sustain."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1039\/C6MD00124F","article-title":"Nanoparticles vs. biofilms: A battle against another paradigm of antibiotic resistance","volume":"7","author":"Qayyum","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1208\/s12248-012-9339-4","article-title":"Challenges in Development of Nanoparticle-Based Therapeutics","volume":"14","author":"Desai","year":"2012","journal-title":"AAPS J."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1162\/GLEP_a_00096","article-title":"Regulating Nanotechnologies: Risk, Uncertainty and the Global Governance Gap","volume":"12","author":"Falkner","year":"2012","journal-title":"Glob. Environ. Politics"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1567-1364.2006.00117.x","article-title":"Candida biofilms on implanted biomaterials: A clinically significant problem","volume":"6","author":"Ramage","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s40883-019-00116-3","article-title":"A Review on Surface Modifications and Coatings on Implants to Prevent Biofilm","volume":"6","author":"Narayana","year":"2020","journal-title":"Regen. Eng. Transl. Med."},{"key":"ref_334","doi-asserted-by":"crossref","unstructured":"Kanematsu, H., and Barry, D.M. (2015). Biofilm Formation on Medical Devices and Infection: Preventive Approaches. Biofilm and Materials Science, Springer International Publishing.","DOI":"10.1007\/978-3-319-14565-5"},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Singh, A.V., Vyas, V., Patil, R., Sharma, V., Scopelliti, P.E., Bongiorno, G., Podest\u00e0, A., Lenardi, C., Gade, W.N., and Milani, P. (2011). Quantitative characterization of the influence of the nanoscale morphology of nanostructured surfaces on bacterial adhesion and biofilm formation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025029"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.biotechadv.2013.10.015","article-title":"Biomaterials surfaces capable of resisting fungal attachment and biofilm formation","volume":"32","author":"Coad","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2015.11.010","article-title":"Polysaccharide-based antibiofilm surfaces","volume":"30","author":"Junter","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.3168\/jds.2014-7912","article-title":"Antioxidant and antibacterial activities of exopolysaccharides from Bifidobacterium bifidum WBIN03 and Lactobacillus plantarum R315","volume":"97","author":"Li","year":"2014","journal-title":"J. Dairy. Sci."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1462-2920.2012.02810.x","article-title":"Antibiofilm polysaccharides","volume":"15","author":"Rendueles","year":"2013","journal-title":"Environ. Microbiol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1128\/AAC.01274-13","article-title":"Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability","volume":"58","author":"Delattin","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_341","doi-asserted-by":"crossref","unstructured":"Gutierrez-Gongora, D., Woods, M., Prosser, R.S., and Geddes-McAlister, J. (2024). Natural compounds from freshwater mussels disrupt fungal virulence determinants and influence fluconazole susceptibility in the presence of macrophages in Cryptococcus neoformans. Microbiol. Spectr., 12.","DOI":"10.1128\/spectrum.02841-23"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1086\/651558","article-title":"Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model","volume":"201","author":"Martinez","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/cb400009f","article-title":"Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates","volume":"8","author":"You","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1615\/JLongTermEffMedImplants.v16.i1.90","article-title":"Implant-associated infections: An overview","volume":"16","author":"Hedrick","year":"2006","journal-title":"J. Long. Term. Eff. Med. Implant."},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Oliva, A., Miele, M.C., Al Ismail, D., Di Timoteo, F., De Angelis, M., Rosa, L., Cutone, A., Venditti, M., Mascellino, M.T., and Valenti, P. (2021). Challenges in the Microbiological Diagnosis of Implant-Associated Infections: A Summary of the Current Knowledge. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.750460"},{"key":"ref_346","doi-asserted-by":"crossref","unstructured":"Mikzi\u0144ski, P., Kraus, K., Widelski, J., and Paluch, E. (2024). Modern Microbiological Methods to Detect Biofilm Formation in Orthopedy and Suggestions for Antibiotic Therapy, with Particular Emphasis on Prosthetic Joint Infection (PJI). Microorganisms, 12.","DOI":"10.3390\/microorganisms12061198"},{"key":"ref_347","doi-asserted-by":"crossref","unstructured":"Cleaver, L., and Garnett, J.A. (2023). How to study biofilms: Technological advancements in clinical biofilm research. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1335389"},{"key":"ref_348","doi-asserted-by":"crossref","unstructured":"Tsikopoulos, A., Tsikopoulos, K., Sidiropoulos, K., Meroni, G., Triaridis, S., Drago, L., and Papaioannidou, P. (2024). Development and Prevention of Biofilm on Cochlear Implants: A Systematic Review. Medicina, 60.","DOI":"10.3390\/medicina60121959"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/JS9.0000000000000036","article-title":"Recent advances in the treatment of biofilms induced surgical site infections","volume":"109","author":"Chopra","year":"2023","journal-title":"Int. J. Surg."},{"key":"ref_350","unstructured":"World Health Organization (2022). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action, World Health Organization. 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