{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:40:53Z","timestamp":1788813653490,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian National Research, Development and Innovation Office","award":["NKFIH FK138462"],"award-info":[{"award-number":["NKFIH FK138462"]}]},{"name":"Hungarian National Research, Development and Innovation Office","award":["150834"],"award-info":[{"award-number":["150834"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Trichophyton indotineae is associated with difficult-to-treat, often extensive dermatophytosis and resistance to the commonly used antifungal agents. Successful therapy often necessitates higher than usual doses of systemic therapy for prolonged periods. The spread of this species has gained much attention lately, as several European and other Western hemisphere countries have recently reported their first respective cases or increasing numbers of them. Until recently, this species was not described in Hungary. Here, we report a case caused by this species in a patient with a travel history to an endemic region. The isolate was identified preliminarily by MALDI-TOF mass spectrometry and confirmed by DNA sequencing; furthermore, it was subject to phenotypic antifungal susceptibility testing by broth microdilution to fluconazole, voriconazole, posaconazole, itraconazole, and terbinafine. According to the susceptibility results, the isolate was wild type to all tested agents, including terbinafine which was in line with the sequencing data, and with the uncommon excellent therapeutic response to topical allylamine treatment. This case also further confirms the applicability of the MSI-2 database for the rapid identification of T. indotineae in routine clinical microbiology laboratories as a cost-effective and simple method.<\/jats:p>","DOI":"10.3390\/jof11040248","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:45:08Z","timestamp":1742899508000},"page":"248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["First Report of Trichophyton indotineae Infection in Hungary"],"prefix":"10.3390","volume":"11","author":[{"given":"Zolt\u00e1n","family":"T\u00f3th","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"V\u00e1nyai","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Dermatology Clinic, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-2424","authenticated-orcid":false,"given":"Ren\u00e1t\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-0656","authenticated-orcid":false,"given":"\u00c1gnes","family":"Jakab","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-9014","authenticated-orcid":false,"given":"Andrea","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Dermatology Clinic, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Majoros","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11046-020-00455-8","article-title":"Trichophyton indotineae sp. nov.: A New Highly Terbinafine-Resistant Anthropophilic Dermatophyte Species","volume":"185","author":"Kano","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101383","DOI":"10.1016\/j.mycmed.2023.101383","article-title":"Trichophyton indotineae, from epidemiology to therapeutic","volume":"33","author":"Jabet","year":"2023","journal-title":"J. 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