{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:39Z","timestamp":1792789479288,"version":"4.5.0"},"reference-count":164,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Potosino de Ciencia y Tecnolog\u00eda","award":["23871"],"award-info":[{"award-number":["23871"]}]},{"name":"Consejo Potosino de Ciencia y Tecnolog\u00eda","award":["CBF2023-2024-655"],"award-info":[{"award-number":["CBF2023-2024-655"]}]},{"name":"SECIHTY, Mexico","award":["23871"],"award-info":[{"award-number":["23871"]}]},{"name":"SECIHTY, Mexico","award":["CBF2023-2024-655"],"award-info":[{"award-number":["CBF2023-2024-655"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The Candida species cell wall plays a pivotal role as a structural and functional barrier against external aggressors and as an intermediary in host\u2013pathogen interactions. Candida species exhibit unique adaptations in their cell wall composition, with varying proportions of chitin, mannans, and \u03b2-glucans influenced by the environmental conditions and the morphological states. These components not only maintain cellular viability under osmotic, thermal, and chemical stress, but also serve as the key targets for novel antifungal strategies. MAPK signaling pathways, like the cell wall integrity pathway and the high-osmolarity glycerol pathway, play a crucial role in responding to cell wall stressors. Due to the rise of antifungal resistance and its clinical challenges, there is a need to identify new antifungal targets. This review discusses the recent advances in understanding the mechanisms underlying cell wall integrity, their impact on antifungal resistance and virulence, and their potential as therapeutic targets of C. albicans, N. glabratus, and C. auris.<\/jats:p>","DOI":"10.3390\/jof11040271","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:08:40Z","timestamp":1743505720000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-2064","authenticated-orcid":false,"given":"Iv\u00e1n A.","family":"Banda-Flores","sequence":"first","affiliation":[{"name":"Facultad de Estudios Profesionales Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9874-1491","authenticated-orcid":false,"given":"David","family":"Torres-Tirado","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Profesionales Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-0595","authenticated-orcid":false,"given":"H\u00e9ctor M.","family":"Mora-Montes","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda, Divisi\u00f3n de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s\/n, Col. Noria Alta, Guanajuato 36050, Guanajuato, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7557","authenticated-orcid":false,"given":"Gabriela","family":"P\u00e9rez-Flores","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Profesionales Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5800-2987","authenticated-orcid":false,"given":"Luis A.","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Profesionales Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Romualdo del Campo 501, Fracc. 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Antibiotics, 11.","DOI":"10.3390\/antibiotics11060718"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chest.2021.08.081","article-title":"Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"161","author":"Schlattmann","year":"2022","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Stenkiewicz-Witeska, J.S., and Ene, I.V. (2023). Azole Potentiation in Candida Species. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011583"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mroczy\u0144ska, M., and Brillowska-D\u0105browska, A. (2020). Review on Current Status of Echinocandins Use. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050227"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s00134-020-06240-x","article-title":"Invasive Candidiasis in Critical Care: Challenges and Future Directions","volume":"46","author":"Logan","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fr\u00edas-De-Le\u00f3n, M.G., Hern\u00e1ndez-Castro, R., Vite-Gar\u00edn, T., Arenas, R., Bonifaz, A., Casta\u00f1\u00f3n-Olivares, L., Acosta-Altamirano, G., and Mart\u00ednez-Herrera, E. (2020). Antifungal Resistance in Candida Auris: Molecular Determinants. Antibiotics, 9.","DOI":"10.3390\/antibiotics9090568"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Czajka, K.M., Venkataraman, K., Brabant-Kirwan, D., Santi, S.A., Verschoor, C., Appanna, V.D., Singh, R., Saunders, D.P., and Tharmalingam, S. (2023). Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species. Cells, 12.","DOI":"10.3390\/cells12222655"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Paul, S., Shaw, D., Joshi, H., Singh, S., Chakrabarti, A., Rudramurthy, S.M., and Ghosh, A.K. (2022). Mechanisms of Azole Antifungal Resistance in Clinical Isolates of Candida tropicalis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0269721"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Milholland, K.L., AbdelKhalek, A., Baker, K.M., Hoda, S., DeMarco, A.G., Naughton, N.H., Koeberlein, A.N., Lorenz, G.R., Anandasothy, K., and Esperilla-Mu\u00f1oz, A. (2022). Reduced Cdc14 Phosphatase Activity Impairs Septation, Hyphal Differentiation and Pathogenesis and Causes Echinocandin Hypersensitivity in Candida albicans. bioRxiv.","DOI":"10.1101\/2022.09.29.510203"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100047","DOI":"10.1016\/j.tcsw.2020.100047","article-title":"Scalar Nanostructure of the Candida Albicans Cell Wall; a Molecular, Cellular and Ultrastructural Analysis and Interpretation","volume":"6","author":"Lenardon","year":"2020","journal-title":"Cell Surf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100063","DOI":"10.1016\/j.tcsw.2021.100063","article-title":"Prospects for Anti-Candida Therapy through Targeting the Cell Wall: A Mini-Review","volume":"7","author":"Ahmadipour","year":"2021","journal-title":"Cell Surf."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Garcia-Rubio, R., Hernandez, R.Y., Clear, A., Healey, K.R., Shor, E., and Perlin, D.S. (2021). Critical Assessment of Cell Wall Integrity Factors Contributing to in Vivo Echinocandin Tolerance and Resistance in Candida glabrata. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.702779"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tcsw.2018.10.001","article-title":"Fission Yeast Cell Wall Biosynthesis and Cell Integrity Signalling","volume":"4","author":"Cansado","year":"2018","journal-title":"Cell Surf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tim.2018.01.007","article-title":"Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion","volume":"26","author":"Hopke","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Stewart, G.G. (2017). The Structure and Function of the Yeast Cell Wall, Plasma Membrane and Periplasm. Brewing and Distilling Yeasts, Springer International Publishing.","DOI":"10.1007\/978-3-319-69126-8_5"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Garc\u00eda, L.A., Csonka, K., Flores-Carre\u00f3n, A., Estrada-Mata, E., Mellado-Mojica, E., N\u00e9meth, T., L\u00f3pez-Ram\u00edrez, L.A., Toth, R., L\u00f3pez, M.G., and Vizler, C. (2016). Role of Protein Glycosylation in Candida parapsilosis Cell Wall Integrity and Host Interaction. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00306"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ribeiro, R.A., Bourbon-Melo, N., and S\u00e1-Correia, I. (2022). The Cell Wall and the Response and Tolerance to Stresses of Biotechnological Relevance in Yeasts. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.953479"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bemena, L.D., Min, K., Konopka, J.B., and Neiman, A.M. (2021). A Conserved Machinery Underlies the Synthesis of a Chitosan Layer in the Candida Chlamydospore Cell Wall. mSphere, 6.","DOI":"10.1128\/mSphere.00080-21"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/EC.00210-10","article-title":"Proteolytic Cleavage of Covalently Linked Cell Wall Proteins by Candida Albicans Sap9 and Sap10","volume":"10","author":"Schild","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"ref_21","first-page":"83","article-title":"Chitin: A \u201cHidden Figure\u201d in the Fungal Cell Wall","volume":"425","author":"Brown","year":"2020","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Garcia-Rubio, R., de Oliveira, H.C., Rivera, J., and Trevijano-Contador, N. (2020). The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02993"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100061","DOI":"10.1016\/j.tcsw.2021.100061","article-title":"Glucan and Glycogen Exist as a Covalently Linked Macromolecular Complex in the Cell Wall of Candida Albicans and Other Candida Species","volume":"7","author":"Lowman","year":"2021","journal-title":"Cell Surf."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"de Assis, L.J., Bain, J.M., Liddle, C., Leaves, I., Hacker, C., da Silva, R.P., Yuecel, R., Bebes, A., Stead, D., and Childers, D.S. (2022). Nature of B-1,3-Glucan-Exposing Features on Candida Albicans Cell Wall and Their Modulation. mBio, 13.","DOI":"10.1128\/mbio.02605-22"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1038\/s41467-022-31201-x","article-title":"Innate Immune Responses against the Fungal Pathogen Candida Auris","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Widanage, M.C.D., Singh, K., Li, J., Yarava, J.R., Scott, F.J., Xu, Y., Gow, N.A.R., Mentink-Vigier, F., Wang, P., and Lamoth, F. (2024). Unveiling Cell Wall Structure and Echinocandin Response in Candida Auris and Candida Albicans via Solid-State NMR. bioRxiv.","DOI":"10.1101\/2024.12.02.626508"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/IDR.S197531","article-title":"Differential Recognition of Candida tropicalis, Candida Guilliermondii, Candida Krusei, and Candida Auris by Human Innate Immune Cells","volume":"12","author":"Franco","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1111\/j.1742-4658.2012.08564.x","article-title":"Significant Differences in the Cell-Wall Mannans from Three Candida glabrata Strains Correlate with Antifungal Drug Sensitivity","volume":"279","author":"Takahashi","year":"2012","journal-title":"FEBS J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/1120009X.2016.1199507","article-title":"Cell Wall Composition and Biofilm Formation of Azoles-Susceptible and -Resistant Candida glabrata Strains","volume":"29","author":"Vitali","year":"2017","journal-title":"J. Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/cyto.a.22250","article-title":"Determination of Chitin Content in Fungal Cell Wall: An Alternative Flow Cytometric Method","volume":"83A","author":"Silva","year":"2013","journal-title":"Cytom. Part A"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.fgb.2008.08.003","article-title":"Functional Analysis of Candida Albicans GPI-Anchored Proteins: Roles in Cell Wall Integrity and Caspofungin Sensitivity","volume":"45","author":"Plaine","year":"2008","journal-title":"Fungal. Genet. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/femsyr\/foae039","article-title":"The Good, the Bad, and the Hazardous: Comparative Genomic Analysis Unveils Cell Wall Features in the Pathogen Candidozyma Auris Typical for Both Baker\u2019s Yeast and Candida","volume":"24","author":"Alvarado","year":"2024","journal-title":"FEMS Yeast Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Duggan, S., and Usher, J. (2023). Candida glabrata: A Powerhouse of Resistance. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011651"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e0091024","DOI":"10.1128\/msphere.00910-24","article-title":"An Alteration in the Expression of Cell Wall Structural Proteins Increases Cell Surface Exposure of Adhesins to Promote Virulence in Candida glabrata","volume":"9","author":"Zhang","year":"2024","journal-title":"mSphere"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kim, J., Oh, S.H., Rodriguez-Bobadilla, R., Vuong, V.M., Hubka, V., Zhao, X., and Hoyer, L.L. (2022). Peering Into Candida Albicans Pir Protein Function and Comparative Genomics of the Pir Family. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.836632"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/EC.3.4.955-965.2004","article-title":"Proteomic Analysis of Candida Albicans Cell Walls Reveals Covalently Bound Carbohydrate-Active Enzymes and Adhesins","volume":"3","author":"Cunningham","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/jac\/dkab454","article-title":"Genotypic, Proteomic, and Phenotypic Approaches to Decipher the Response to Caspofungin and Calcineurin Inhibitors in Clinical Isolates of Echinocandin-Resistant Candida glabrata","volume":"77","author":"Monteoliva","year":"2022","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Satala, D., Karkowska-Kuleta, J., Zelazna, A., Rapala-Kozik, M., and Kozik, A. (2020). Moonlighting Proteins at the Candidal Cell Surface. Microorganisms, 8.","DOI":"10.3390\/microorganisms8071046"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e14001","DOI":"10.7717\/peerj.14001","article-title":"Moonlighting Proteins in Medically Relevant Fungi","volume":"10","year":"2022","journal-title":"PeerJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1365-2958.2005.04771.x","article-title":"The Moonlighting Protein Tsa1p Is Implicated in Oxidative Stress Response and in Cell Wall Biogenesis in Candida Albicans","volume":"57","author":"Urban","year":"2005","journal-title":"Mol. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Paudyal, A., and Vediyappan, G. (2021). Cell Surface Expression of Nrg1 Protein in Candida Auris. J. Fungi, 7.","DOI":"10.3390\/jof7040262"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Karkowska-Kuleta, J., Satala, D., Bochenska, O., Rapala-Kozik, M., and Kozik, A. (2019). Moonlighting Proteins Are Variably Exposed at the Cell Surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under Certain Growth Conditions. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1524-5"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gow, N.A.R., Latge, J.-P., and Munro, C.A. (2017). The Fungal Cell Wall: Structure, Biosynthesis, and Function. Microbiol. Spectr., 5.","DOI":"10.1128\/microbiolspec.FUNK-0035-2016"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liu, N.N., Acosta-Zald\u00edvar, M., Qi, W., Diray-Arce, J., Walker, L.A., Kottom, T.J., Kelly, R., Yuan, M., Asara, J.M., and Lasky-Su, J.A. (2020). Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida Albicans Cell Wall Maintenance. mBio, 11.","DOI":"10.1128\/mBio.03225-19"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/21505594.2022.2026037","article-title":"From Environmental Adaptation to Host Survival: Attributes That Mediate Pathogenicity of Candida Auris","volume":"13","author":"Allert","year":"2022","journal-title":"Virulence"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"K\u00f6hler, J.R., Acosta-Zald\u00edvar, M., and Qi, W. (2020). Phosphate in Virulence of Candida Albicans and Candida glabrata. J. Fungi, 6.","DOI":"10.3390\/jof6020040"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ibe, C., and Munro, C.A. (2021). Fungal Cell Wall: An Underexploited Target for Antifungal Therapies. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009470"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Razmi, M., Kim, J., Chinnici, J., Busarajan, S., Vuppalapaty, H., Lankipalli, D., Li, R., and Maddi, A. (2024). Candida Albicans Mannosidases, Dfg5 and Dcw1, Are Required for Cell Wall Integrity and Pathogenesis. J. Fungi, 10.","DOI":"10.20944\/preprints202406.1097.v1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e00554-23","DOI":"10.1128\/msphere.00554-23","article-title":"Calcineurin-Dependent Contributions to Fitness in the Opportunistic Pathogen Candida glabrata","volume":"9","author":"Pavesic","year":"2024","journal-title":"mSphere"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1016\/j.csbj.2021.09.007","article-title":"Transcriptional and Translational Landscape of Candida Auris in Response to Caspofungin","volume":"19","author":"Amatuzzi","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.1074\/jbc.RA117.001225","article-title":"Ras Signaling Activates Glycosylphosphatidylinositol (GPI) Anchor Biosynthesis via the GPI\u2013N-Acetylglucosaminyltransferase (GPI\u2013GnT) in Candida Albicans","volume":"293","author":"Jain","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"de Oliveira, H.C., Rossi, S.A., Garc\u00eda-Barbaz\u00e1n, I., Zaragoza, \u00d3., and Trevijano-Contador, N. (2021). Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in Cryptococcus Neoformans. J. Fungi, 7.","DOI":"10.3390\/jof7100831"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10123-019-00092-2","article-title":"Not Just the Wall: The Other Ways to Turn the Yeast CWI Pathway On","volume":"23","author":"Molina","year":"2020","journal-title":"Int. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ibe, C., and Munro, C.A. (2021). Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat Stresses. J. Fungi, 7.","DOI":"10.3390\/jof7090739"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sanz, A.B., D\u00edez-Mu\u00f1iz, S., Moya, J., Petryk, Y., Nombela, C., Rodr\u00edguez-Pe\u00f1a, J.M., and Arroyo, J. (2022). Systematic Identification of Essential Genes Required for Yeast Cell Wall Integrity: Involvement of the RSC Remodelling Complex. J. Fungi, 8.","DOI":"10.3390\/jof8070718"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e03285-22","DOI":"10.1128\/spectrum.03285-22","article-title":"Associations of Rap1 with Cell Wall Integrity, Biofilm Formation, and Virulence in Candida Albicans","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jmii.2018.04.002","article-title":"Candida Albicans Aro1 Affects Cell Wall Integrity, Biofilm Formation and Virulence","volume":"53","author":"Yeh","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Shivarathri, R., Jenull, S., Stoiber, A., Chauhan, M., Mazumdar, R., Singh, A., Nogueira, F., Kuchler, K., Chowdhary, A., and Chauhan, N. (2020). The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida Auris. mSphere, 5.","DOI":"10.1128\/mSphere.00973-20"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Heredia, M.Y., Ikeh, M.A.C., Gunasekaran, D., Conrad, K.A., Filimonava, S., Marotta, D.H., Nobile, C.J., and Rauceo, J.M. (2020). An Expanded Cell Wall Damage Signaling Network Is Comprised of the Transcription Factors Rlm1 and Sko1 in Candida Albicans. PLoS Genet., 16.","DOI":"10.1371\/journal.pgen.1008908"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kim, J.-S., Lee, K.-T., Lee, M.H., Cheong, E., and Bahn, Y.-S. (2021). Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida Auris. mBio, 12.","DOI":"10.1128\/mBio.02729-21"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Rubio, G., Sastre-Vergara, L., Molina, M., Mart\u00edn, H., and Fern\u00e1ndez-Acero, T. (2022). Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity. J. Fungi, 8.","DOI":"10.3390\/jof8040368"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sanz, A.B., Garc\u00eda, R., Rodr\u00edguez-Pe\u00f1a, J.M., and Arroyo, J. (2018). The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast. J. Fungi, 4.","DOI":"10.3390\/jof4010001"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Balachandra, V.K., Verma, J., Shankar, M., Tucey, T.M., Traven, A., Schittenhelm, R.B., and Ghosh, S.K. (2020). The RSC (Remodels the Structure of Chromatin) Complex of Candida Albicans Shows Compositional Divergence with Distinct Roles in Regulating Pathogenic Traits. PLoS Genet., 16.","DOI":"10.1371\/journal.pgen.1009071"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sanz, A.B., Garc\u00eda, R., Pav\u00f3n-Verg\u00e9s, M., Rodr\u00edguez-Pe\u00f1a, J.M., and Arroyo, J. (2022). Control of Gene Expression via the Yeast CWI Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031791"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Wang, L., Chen, R., Weng, Q., Lin, S., Wang, H., Li, L., Fuchs, B.B., Tan, X., and Mylonakis, E. (2020). SPT20 Regulates the Hog1-MAPK Pathway and Is Involved in Candida Albicans Response to Hyperosmotic Stress. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00213"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Dong, Y., Du, J., Deng, Y., Cheng, M., Shi, Z., Zhu, H., Sun, H., Yu, Q., and Li, M. (2024). Reduction of Histone Proteins Dosages Increases CFW Sensitivity and Attenuates Virulence of Candida Albicans. Microbiol. Res., 279.","DOI":"10.1016\/j.micres.2023.127552"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/1567-1364.12022","article-title":"The Transcriptional Control Machinery as Well as the Cell Wall Integrity and Its Regulation Are Involved in the Detoxification of the Organic Solvent Dimethyl Sulfoxide in Saccharomyces Cerevisiae","volume":"13","author":"Zhang","year":"2013","journal-title":"FEMS Yeast Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1093\/nar\/gkaa081","article-title":"A Genetic Analysis Reveals Novel Histone Residues Required for Transcriptional Reprogramming upon Stress","volume":"48","author":"Potel","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chen, C., Zhang, Y., Zeng, L., HUANG, X., Wang, Y., Chen, G., Moses, M., Zou, Y., Xiong, S., and Xue, W. (2024). Targeting Epigenetic Regulators to Overcome Drug Resistance in the Emerging Human Fungal Pathogen Candida Auris. preprint.","DOI":"10.21203\/rs.3.rs-5359114\/v1"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"109607","DOI":"10.1016\/j.isci.2024.109607","article-title":"SWI\/SNF Complex-Mediated Chromatin Remodeling in Candida glabrata Promotes Immune Evasion","volume":"27","author":"Kumar","year":"2024","journal-title":"iScience"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Filler, E.E., Liu, Y., Solis, N.V., Wang, L., Diaz, L.F., Edwards, J.E., Filler, S.G., and Yeaman, M.R. (2021). Identification of Candida glabrata Transcriptional Regulators That Govern Stress Resistance and Virulence. Infect. Immun., 89.","DOI":"10.1128\/IAI.00146-20"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2217\/fmb-2019-0343","article-title":"Histone Acetylation\/Deacetylation in Candida Albicans and Their Potential as Antifungal Targets","volume":"15","author":"Su","year":"2020","journal-title":"Future Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"112184","DOI":"10.1016\/j.celrep.2023.112184","article-title":"A Posttranscriptional Pathway Regulates Cell Wall MRNA Expression in Budding Yeast","volume":"42","author":"Bresson","year":"2023","journal-title":"Cell Rep."},{"key":"ref_74","unstructured":"Jnied, M.M. (2024). Post-Transcriptional Regulation of Fungal Cell Walls by RNA-Binding Proteins and Untranslated Regions. [Ph.D. Thesis, Institute of Cell and Molecular Biology, School of Biological Sciences, University of Edinburgh]."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Healey, K.R., Paderu, P., Hou, X., Jimenez Ortigosa, C., Bagley, N., Patel, B., Zhao, Y., and Perlin, D.S. (2020). Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1. J. Fungi, 6.","DOI":"10.3390\/jof6030143"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100074","DOI":"10.1016\/j.tcsw.2022.100074","article-title":"Post-Transcriptional Control of Fungal Cell Wall Synthesis","volume":"8","author":"Hall","year":"2022","journal-title":"Cell Surf."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ca\u00f1onero, L., Pautasso, C., Galello, F., Sigaut, L., Pietrasanta, L., Arroyo, J., Berm\u00fadez-Moretti, M., Portela, P., and Rossi, S. (2022). Heat Stress Regulates the Expression of TPK1 Gene at Transcriptional and Post-Transcriptional Levels in Saccharomyces Cerevisiae. Biochim. et Biophys. Acta (BBA)-Mol. Cell Res., 1869.","DOI":"10.1016\/j.bbamcr.2021.119209"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhang, W., Long, S., and Zhao, C. (2021). Maintenance of Cell Wall Integrity under High Salinity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063260"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1021\/acs.jmedchem.0c00748","article-title":"Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall","volume":"63","author":"Liu","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"103953","DOI":"10.1016\/j.isci.2022.103953","article-title":"The Role of Candida Albicans Stress Response Pathways in Antifungal Tolerance and Resistance","volume":"25","author":"Iyer","year":"2022","journal-title":"iScience"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2958.2005.04843.x","article-title":"Cell Wall Integrity Is Dependent on the PKC1 Signal Transduction Pathway in Cryptococcus Neoformans","volume":"58","author":"Gerik","year":"2005","journal-title":"Mol. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Alonso-Monge, R., Guirao-Abad, J.P., S\u00e1nchez-Fresneda, R., Pla, J., Yag\u00fce, G., and Arg\u00fcelles, J.C. (2020). The Fungicidal Action of Micafungin Is Independent on Both Oxidative Stress Generation and HOG Pathway Signaling in Candida Albicans. Microorganisms, 8.","DOI":"10.3390\/microorganisms8121867"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e21778","DOI":"10.1096\/fj.202100278R","article-title":"Poacic Acid, a \u03b2-1,3-Glucan\u2013Binding Antifungal Agent, Inhibits Cell-Wall Remodeling and Activates Transcriptional Responses Regulated by the Cell-Wall Integrity and High-Osmolarity Glycerol Pathways in Yeast","volume":"35","author":"Chen","year":"2021","journal-title":"FASEB J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"foac035","DOI":"10.1093\/femsyr\/foac035","article-title":"Yeast Osmoregulation\u2013Glycerol Still in Pole Position","volume":"22","author":"Blomberg","year":"2022","journal-title":"FEMS Yeast Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"foac013","DOI":"10.1093\/femsyr\/foac013","article-title":"The HOG Pathway and the Regulation of Osmoadaptive Responses in Yeast","volume":"22","author":"Posas","year":"2022","journal-title":"FEMS Yeast Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"RP88750","DOI":"10.7554\/eLife.88750","article-title":"Yeast Cell Responses and Survival during Periodic Osmotic Stress Are Controlled by Glucose Availability","volume":"12","author":"Duveau","year":"2024","journal-title":"Elife"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s42770-021-00427-0","article-title":"Rapid and Reversible Cell Volume Changes in Response to Osmotic Stress in Yeast","volume":"52","author":"Villava","year":"2021","journal-title":"Braz. J. Microbiol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Herrero-de-Dios, C., Rom\u00e1n, E., Pla, J., and Alonso-Monge, R. (2020). Hog1 Controls Lipids Homeostasis Upon Osmotic Stress in Candida Albicans. J. Fungi, 6.","DOI":"10.3390\/jof6040355"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3892\/etm.2021.9907","article-title":"HOG1 Has an Essential Role in the Stress Response, Virulence and Pathogenicity of EmCryptococcus Gattii\/Em","volume":"21","author":"Huang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Guirao-Abad, J.P., S\u00e1nchez-Fresneda, R., Rom\u00e1n, E., Pla, J., Arg\u00fcelles, J.C., and Alonso-Monge, R. (2020). The MAPK Hog1 Mediates the Response to Amphotericin B in Candida Albicans. Fungal Genet. Biol., 136.","DOI":"10.1016\/j.fgb.2019.103302"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Sahu, M.S., Purushotham, R., and Kaur, R. (2024). The Hog1 MAPK Substrate Governs Candida glabrata-Epithelial Cell Adhesion via the Histone H2A Variant. PLoS Genet., 20.","DOI":"10.1371\/journal.pgen.1011281"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e00016-20","DOI":"10.1128\/mSphere.00016-20","article-title":"Inhibition of Respiration of Candida Albicans by Small Molecules Increases Phagocytosis Efficacy by Macrophages","volume":"5","author":"Cui","year":"2020","journal-title":"mSphere"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/iub.2476","article-title":"Naringin-Generated ROS Promotes Mitochondria-Mediated Apoptosis in Candida albicans","volume":"73","author":"Kim","year":"2021","journal-title":"IUBMB Life"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1128\/AAC.01271-10","article-title":"Loss of Mitochondrial Functions Associated with Azole Resistance in Candida glabrata Results in Enhanced Virulence in Mice","volume":"55","author":"Ferrari","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Simm, C., Weerasinghe, H., Thomas, D.R., Harrison, P.F., Newton, H.J., Beilharz, T.H., and Traven, A. (2022). Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida Auris. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.00100-22"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/21505594.2020.1748930","article-title":"The Regulation of Hyphae Growth in Candida Albicans","volume":"11","author":"Chen","year":"2020","journal-title":"Virulence"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.devcel.2021.09.024","article-title":"Detection of Surface Forces by the Cell-Wall Mechanosensor Wsc1 in Yeast","volume":"56","author":"Diaz","year":"2021","journal-title":"Dev. Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/genetics\/152.4.1487","article-title":"Characterization of the Wsc1 Protein, a Putative Receptor in the Stress Response of Saccharomyces Cerevisiae","volume":"152","author":"Lodder","year":"1999","journal-title":"Genetics"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Puerner, C., Kukhaleishvili, N., Thomson, D., Schaub, S., Noblin, X., Seminara, A., Bassilana, M., and Arkowitz, R.A. (2020). Mechanical Force-Induced Morphology Changes in a Human Fungal Pathogen. BMC Biol., 18.","DOI":"10.1186\/s12915-020-00833-0"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-0716-2417-3_15","article-title":"High-Pressure Freezing and Transmission Electron Microscopy to Visualize the Ultrastructure of the C. Auris Cell Wall","volume":"2517","author":"Milne","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.3103\/S0096392523700220","article-title":"Structural Study of the Candida Auris Ribosome","volume":"78","author":"Atamas","year":"2023","journal-title":"Mosc. Univ. Biol. Sci. Bull."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jiang, J., Keniya, M.V., Puri, A., Zhan, X., Cheng, J., Wang, H., Lin, G., Lee, Y.-K., Jaber, N., and Hassoun, Y. (2024). Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata. bioRxiv.","DOI":"10.1101\/2024.05.29.596243"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Ortigosa, C., Jiang, J., Chen, M., Kuang, X., Healey, K.R., Castellano, P., Boparai, N., Ludtke, S.J., Perlin, D.S., and Dai, W. (2021). Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins. J. Fungi, 7.","DOI":"10.3390\/jof7020120"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1017\/S143192762200472X","article-title":"Elucidating the 3D Structure of \u03b2-(1,3)-Glucan Synthase from Candida glabrata by Subtomogram Averaging","volume":"28","author":"Jiang","year":"2022","journal-title":"Microsc. Microanal."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1002\/1873-3468.13948","article-title":"The Promise and the Challenges of Cryo-Electron Tomography","volume":"594","author":"Turk","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Petrokilidou, C., Pavlou, E., Velegraki, A., Simou, A., Marsellou, I., Filis, G., Bassukas, I.D., Gaitanis, G., and Kourkoumelis, N. (2024). Characterization and Differentiation of Candida Auris on Dixon\u2019s Agar Using Raman Spectroscopy. Pathogens, 13.","DOI":"10.3390\/pathogens13110978"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-genom-120219-073756","article-title":"RNA Conformation Capture by Proximity Ligation","volume":"21","author":"Kudla","year":"2020","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1038\/s41467-020-18035-1","article-title":"ATAC-Seq Footprinting Unravels Kinetics of Transcription Factor Binding during Zygotic Genome Activation","volume":"11","author":"Bentsen","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1080\/21505594.2021.1949883","article-title":"The Two-Component Signal Transduction System and Its Regulation in Candida Albicans","volume":"12","author":"Liao","year":"2021","journal-title":"Virulence"},{"key":"ref_110","first-page":"117863372110269","article-title":"Candida Bloodstream Infections: Changes in Epidemiology and Increase in Drug Resistance","volume":"14","author":"Kotey","year":"2021","journal-title":"Infect. Dis. Res. Treat."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Parslow, B.Y., and Thornton, C.R. (2022). Continuing Shifts in Epidemiology and Antifungal Susceptibility Highlight the Need for Improved Disease Management of Invasive Candidiasis. Microorganisms, 10.","DOI":"10.3390\/microorganisms10061208"},{"key":"ref_112","first-page":"255","article-title":"Cell Wall-Modifying Antifungal Drugs","volume":"425","author":"Perlin","year":"2020","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"C\u00e2ndido, E.d.S., Affonseca, F., Cardoso, M.H., and Franco, O.L. (2020). Echinocandins as Biotechnological Tools for Treating Candida Auris Infections. J. Fungi, 6.","DOI":"10.3390\/jof6030185"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2147\/IDR.S323583","article-title":"Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non-Albicans Candidemia: A Retrospective Observational Study","volume":"14","author":"Liu","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"foac019","DOI":"10.1093\/femsyr\/foac019","article-title":"The Effect of Antifungal Resistance Development on the Virulence of Candida Species","volume":"22","author":"Bohner","year":"2022","journal-title":"FEMS Yeast Res."},{"key":"ref_116","first-page":"279","article-title":"Resistance to Antifungal Drugs","volume":"35","author":"Kontoyiannis","year":"2021","journal-title":"Infect. Dis. Clin."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Sharma, C., and Kadosh, D. (2023). Perspective on the Origin, Resistance, and Spread of the Emerging Human Fungal Pathogen Candida Auris. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011190"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"19816","DOI":"10.1021\/acsomega.3c08134","article-title":"Effect of Conformational Variability on the Drug Resistance of Candida Auris ERG11p and FKS1","volume":"9","author":"Izumi","year":"2024","journal-title":"ACS Omega"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Fr\u00edas-De-le\u00f3n, M.G., Hern\u00e1ndez-Castro, R., Conde-Cuevas, E., Garc\u00eda-Coronel, I.H., V\u00e1zquez-Aceituno, V.A., Soriano-Urs\u00faa, M.A., Farf\u00e1n-Garc\u00eda, E.D., Ochar\u00e1n-Hern\u00e1ndez, E., Rodr\u00edguez-Cerdeira, C., and Arenas, R. (2021). Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13101529"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41467-023-41509-x","article-title":"Genotypic Diversity and Unrecognized Antifungal Resistance among Populations of Candida glabrata from Positive Blood Cultures","volume":"14","author":"Badrane","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44259-024-00043-6","article-title":"Genomic Epidemiology Describes Introduction and Outbreaks of Antifungal Drug-Resistant Candida Auris","volume":"2","author":"Kappel","year":"2024","journal-title":"Npj Antimicrob. Resist."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-med-061523-021233","article-title":"Candida auris: Epidemiology and Antifungal Strategy","volume":"76","author":"Eix","year":"2025","journal-title":"Annu. Rev. Med."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Borgeat, V., Brandalise, D., Grenouillet, F., and Sanglard, D. (2021). Participation of the Abc Transporter Cdr1 in Azole Resistance of Candida Lusitaniae. J. Fungi, 7.","DOI":"10.3390\/jof7090760"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Li, J., Coste, A.T., Liechti, M., Bachmann, D., Sanglard, D., and Lamoth, F. (2021). Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida Auris. Antimicrob. Agents Chemother., 65.","DOI":"10.1128\/AAC.02663-20"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"20220995","DOI":"10.1515\/biol-2022-0995","article-title":"Exploring the Effects of Culture Conditions on Yapsin (YPS) Gene Expression in Nakaseomyces Glabratus","volume":"19","author":"Bednarek","year":"2024","journal-title":"Open Life Sci."},{"key":"ref_126","first-page":"1128","article-title":"Contribution of the Slt2-Regulated Transcription Factors to Echinocandin Tolerance in Candida glabrata","volume":"14","author":"Nagayoshi","year":"2014","journal-title":"FEMS Yeast Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/EC.2.6.1200-1210.2003","article-title":"The Yeast Protein Kinase C Cell Integrity Pathway Mediates Tolerance to the Antifungal Drug Caspofungin through Activation of Slt2p Mitogen-Activated Protein Kinase Signaling","volume":"2","author":"Kuchler","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/mmi.14586","article-title":"Sphingolipids: Regulators of Azole Drug Resistance and Fungal Pathogenicity","volume":"114","author":"Song","year":"2020","journal-title":"Mol. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Chang, C.K., Yang, M.C., Chen, H.F., Liao, Y.L., and Lan, C.Y. (2022). The Role of Sfp1 in Candida Albicans Cell Wall Maintenance. J. Fungi, 8.","DOI":"10.3390\/jof8111196"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"foac045","DOI":"10.1093\/femsyr\/foac045","article-title":"Erg6p Is Essential for Antifungal Drug Resistance, Plasma Membrane Properties and Cell Wall Integrity in Candida glabrata","volume":"22","author":"Elias","year":"2022","journal-title":"FEMS Yeast Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1007\/s00253-021-11371-2","article-title":"O-Vanillin, a Promising Antifungal Agent, Inhibits Aspergillus Flavus by Disrupting the Integrity of Cell Walls and Cell Membranes","volume":"105","author":"Li","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0144-4565(90)90032-F","article-title":"Influence of Phenolics on Biomass Production by Candida Utilis and Candida Albicans","volume":"23","year":"1990","journal-title":"Biomass"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4103\/jomfp.jomfp_273_23","article-title":"Evaluation of Antifungal Activity of Vanilla Pods Silver Nanoparticles against Various Oral Candidal Species: An In-vitro Study","volume":"27","author":"Sri","year":"2023","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/jhet.4277","article-title":"Antimicrobial Effects of Vanillin-Based Pyridyl-Benzylidene-5-Fluoroindolins","volume":"58","author":"Alagumuthu","year":"2021","journal-title":"J. Heterocycl. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/jam.14740","article-title":"Screening the Antifungal Activities of Monoterpenes and Their Isomers against Candida Species","volume":"129","author":"Iraji","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Contreras Mart\u00ednez, O.I., Angulo Ort\u00edz, A., Santaf\u00e9 Pati\u00f1o, G., Pe\u00f1ata-Taborda, A., and Berrio Soto, R. (2023). Isoespintanol Antifungal Activity Involves Mitochondrial Dysfunction, Inhibition of Biofilm Formation, and Damage to Cell Wall Integrity in Candida tropicalis. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202305.1424.v1"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Fernandes, L., Ribeiro, R., Costa, R., Henriques, M., and Rodrigues, M.E. (2022). Essential Oils as a Good Weapon against Drug-Resistant Candida Auris. Antibiotics, 11.","DOI":"10.3390\/antibiotics11070977"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s12223-020-00787-4","article-title":"Phenolic \u2013OH Group Is Crucial for the Antifungal Activity of Terpenoids via Disruption of Cell Membrane Integrity","volume":"65","author":"Konuk","year":"2020","journal-title":"Folia Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Tripathi, S.K., Feng, Q., Liu, L., Levin, D.E., Roy, K.K., Doerksen, R.J., Baerson, S.R., Shi, X., Pan, X., and Xu, W.-H. (2020). Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway. mSphere, 5.","DOI":"10.1128\/mSphere.00818-19"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s11046-019-00370-7","article-title":"In Vitro Interaction of Geldanamycin with Triazoles and Echinocandins Against Common and Emerging Candida Species","volume":"184","author":"Mahmoudi","year":"2019","journal-title":"Mycopathologia"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"17946","DOI":"10.1021\/acs.jmedchem.4c01048","article-title":"Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry","volume":"67","author":"Kitson","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1271\/bbb.70502","article-title":"Inhibition of Ca2+-Signal-Dependent Growth Regulation by Radicicol in Budding Yeast","volume":"72","author":"Chanklan","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12210-022-01118-0","article-title":"Evaluation of the Efficacy of Heat Shock Protein Inhibitors and Antifungal Drug Combinations against Candida spp.","volume":"34","author":"Kiraz","year":"2023","journal-title":"Rend. Lincei"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Xu, L., Liu, Q., Zeng, Q., Wu, P., Yu, Q., Gu, K., Xue, J., and Wei, X. (2021). Radicicol, a Novel Lead Compound against the Migratory-Stage Schistosomula of Schistosoma Japonicum. Antimicrob. Agents Chemother., 65.","DOI":"10.1128\/AAC.01781-20"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.chembiol.2008.02.015","article-title":"Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin","volume":"15","author":"Andersen","year":"2008","journal-title":"Chem. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"711","DOI":"10.15414\/jmbfs.2018.8.1.711-716","article-title":"In-Silico Studies of Some Natural, Synthetic and Semi-Synthetic Antifungal Drugs for Their Multi-Targeting Nature","volume":"8","author":"Neelabh","year":"2018","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1021\/acs.jafc.2c00016","article-title":"Rational Design, Synthesis, and Biological Investigations of N-Methylcarbamoylguanidinyl Azamacrolides as a Novel Chitinase Inhibitor","volume":"70","author":"Zhao","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_148","unstructured":"Rai, M., and Mares, D. (2003). Plant-Derived Antimycotics: Current Trends and Future Prospects, CRC Press."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"155569","DOI":"10.1016\/j.phymed.2024.155569","article-title":"Phytolacca Tetramera Berries Extracts and Its Main Constituents as Potentiators of Antifungal Drugs against Candida spp.","volume":"130","author":"Butassi","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"113961","DOI":"10.1016\/j.ejmech.2021.113961","article-title":"Heat Shock Protein 90 (Hsp90)\/Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Azoles-Resistant Candida Albicans","volume":"227","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1021\/acs.jmedchem.3c00165","article-title":"Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida Albicans","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100076","DOI":"10.1016\/j.tcsw.2022.100076","article-title":"Fluconazole Resistant Candida Auris Clinical Isolates Have Increased Levels of Cell Wall Chitin and Increased Susceptibility to a Glucosamine-6-Phosphate Synthase Inhibitor","volume":"8","author":"Shahi","year":"2022","journal-title":"Cell Surf."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1128\/AAC.01648-07","article-title":"Enhanced Susceptibility to Antifungal Oligopeptides in Yeast Strains Overexpressing ABC Multidrug Efflux Pumps","volume":"52","author":"Gabriel","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1128\/AAC.45.1.223-228.2001","article-title":"Unusual Susceptibility of a Multidrug-Resistant Yeast Strain to Peptidic Antifungals","volume":"45","author":"Milewski","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e0095523","DOI":"10.1128\/aac.00955-23","article-title":"Liposomal Formulation of a New Antifungal Hybrid Compound Provides Protection against Candida Auris in the Ex Vivo Skin Colonization Model","volume":"68","author":"Jaromin","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Espinel-Ingroff, A., and Wiederhold, N.P. (2024). A Mini-Review of In Vitro Data for Candida Species, Including C. Auris, Isolated during Clinical Trials of Three New Antifungals: Fosmanogepix, Ibrexafungerp, and Rezafungin. J. Fungi, 10.","DOI":"10.3390\/jof10050362"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Ghannoum, M., Arendrup, M.C., Chaturvedi, V.P., Lockhart, S.R., McCormick, T.S., Chaturvedi, S., Berkow, E.L., Juneja, D., Tarai, B., and Azie, N. (2020). Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida Auris Infections. Antibiotics, 9.","DOI":"10.3390\/antibiotics9090539"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Nunnally, N.S., Etienne, K.A., Angulo, D., Lockhart, S.R., and Berkow, E.L. (2019). In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations. Antimicrob. Agents Chemother., 63.","DOI":"10.1128\/AAC.01692-19"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Wiederhold, N.P., Najvar, L.K., Olivo, M., Morris, K.N., Patterson, H.P., Catano, G., and Patterson, T.F. (2021). Ibrexafungerp Demonstrates in Vitro Activity against Fluconazole-Resistant Candida Auris and in Vivo Efficacy with Delayed Initiation of Therapy in an Experimental Model of Invasive Candidiasis. Antimicrob. Agents Chemother., 65.","DOI":"10.1128\/AAC.02694-20"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/DDDT.S339349","article-title":"Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis: Design, Development and Place in Therapy","volume":"17","author":"Phillips","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0140-6736(22)02324-8","article-title":"Rezafungin versus Caspofungin for Treatment of Candidaemia and Invasive Candidiasis (ReSTORE): A Multicentre, Double-Blind, Double-Dummy, Randomised Phase 3 Trial","volume":"401","author":"Thompson","year":"2023","journal-title":"Lancet"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1093\/jac\/dkad256","article-title":"Clinical Safety and Efficacy of Novel Antifungal, Fosmanogepix, for the Treatment of Candidaemia: Results from a Phase 2 Trial","volume":"78","author":"Pappas","year":"2023","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S1389-1723(99)80214-X","article-title":"Antifungal Activity of Radicicol against Mucor Flavus IFO 9560","volume":"88","author":"Fujita","year":"1999","journal-title":"J. Biosci. Bioeng."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/np070660i","article-title":"Evidence for the Mechanism of Action of the Antifungal Phytolaccoside B Isolated from Phytolacca Tetramera Hauman","volume":"71","author":"Escalante","year":"2008","journal-title":"J. Nat. Prod."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/4\/271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:07:26Z","timestamp":1760029646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/4\/271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":164,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jof11040271"],"URL":"https:\/\/doi.org\/10.3390\/jof11040271","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}