{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:04:43Z","timestamp":1790395483863,"version":"4.1.0"},"reference-count":276,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Intra-abdominal and gastrointestinal mucormycosis are less frequent than rhino-orbito-cerebral and pulmonary mucormycosis, but highly lethal. Their diagnosis remains challenging due to the non-specific clinical presentation. We collected English-language cases of intra-abdominal and gastrointestinal mucormycosis in non-haematological and non-neonatal patients published up to October 2024. This review analysed the epidemiological, clinical, and therapeutic charts of 290 cases. A proportion of 53.4% were reported from India and the USA. The main predisposing conditions were diabetes, solid organ transplant, ICU, and corticosteroid treatment. The most common site was the stomach (53.8%). Gastrointestinal perforation, skin breakdown, and abdominal wall infection were sources of intra-abdominal localisation. The most common symptoms were abdominal pain, vomiting, and gastrointestinal bleeding. The diagnosis relied on histology (93.8%), mycology with microscopy and culture (38.8%), and molecular methods (9.9%). Mortality (52.9%) was lower when treatment was intravenous amphotericin B, combined or not with surgery. Prompt treatment, essential for a favourable outcome, relies on early suspicion and diagnosis. Gastrointestinal and intra-abdominal mucormycosis should also be suspected in patients admitted in ICU with ventilation\/nasogastric tube and corticosteroids and those with abdominal trauma or surgery, presenting abdominal distension, pain, and GI bleeding. Mycological diagnosis including direct examination, culture and Mucorales qPCR on tissue should assist with rapid diagnosis and thus treatment.<\/jats:p>","DOI":"10.3390\/jof11040298","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:05:56Z","timestamp":1744200356000},"page":"298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gastrointestinal and Intra-Abdominal Mucormycosis in Non-Haematological Patients\u2014A Comprehensive Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Beno\u00eet","family":"Henry","sequence":"first","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, APHP, H\u00f4pital Universitaire de Bic\u00eatre, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-5334","authenticated-orcid":false,"given":"Alain","family":"Lefevre Utile","sequence":"additional","affiliation":[{"name":"Service of Paediatrics, Department Women-Mother-Child, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-5464","authenticated-orcid":false,"given":"Stephane","family":"Jaureguiberry","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, APHP, H\u00f4pital Universitaire de Bic\u00eatre, 94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), U1018, INSERM, 94807 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Angoulvant","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Paris Saclay, AP-HP, 94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1128\/JCM.06133-11","article-title":"Antifungal susceptibility and phylogeny of opportunistic members of the order mucorales","volume":"50","author":"Vitale","year":"2012","journal-title":"J. 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