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Equol, a metabolite of soy isoflavone glycosides, exhibits antifungal activities. In this study, Equol had good inhibitory activity against Candida species. The lowest inhibitory concentration of 125\u2013500 \u03bcg\/mL was confirmed by the gradient dilution method. In addition, transmission electron microscopy and the relative content assay showed that Equol altered the cell wall and membrane of Candida albicans. Further studies found that Equol treatment increased the intracellular levels of reactive oxygen species and Ca2+. Subsequent experiments suggested that Equol treatment depolarized the membrane potential of C. albicans and up-regulated the expression of the apoptosis-inducing factor gene. These results confirmed that Equol damaged the cell wall and membrane, dysregulated the intracellular components, induced oxidative stress and Ca2+ accumulation, and ultimately resulted in mitochondrial dysfunction. Collectively, these findings demonstrated that Equol is a potential antifungal agent.<\/jats:p>","DOI":"10.3390\/jof11050339","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:39:47Z","timestamp":1745833187000},"page":"339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Antifungal Effects of Equol Against Candida albicans Involve Mitochondrial Dysfunction"],"prefix":"10.3390","volume":"11","author":[{"given":"Anni","family":"Ge","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Xin","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-485X","authenticated-orcid":false,"given":"Zhangyong","family":"Song","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"},{"name":"The Public Platform of Molecular Biotechnology, Public Center of Experimental Technology, Southwest Medical University, Luzhou 646000, China"},{"name":"Hemodynamics and Medical Engineering Combination Key Laboratory of Luzhou, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Katsipoulaki, M., Stappers, M.H.T., Malavia-Jones, D., Brunke, S., Hube, B., and Gow, N.A.R. 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