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Early and appropriate antifungal treatment, which is associated with better clinical outcomes, is negatively affected by the increased isolation of non-albicans Candida strains that are resistant to the commonly used azoles and echinocandins. Based on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of the different treatment options, liposomal amphotericin B, rezafungin or high doses of anidulafungin appear to be the most appropriate first-line options for complicated IAC in ICUs.<\/jats:p>","DOI":"10.3390\/jof11050362","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:08:56Z","timestamp":1746522536000},"page":"362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Marco Marotta","family":"Pais","sequence":"first","affiliation":[{"name":"Critical Care Department, Hospital Universitari de Tarragona Joan XXIII, Mallafr\u00e9 Guasch 4, 43007 Tarragona, Spain"},{"name":"Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Rovira & Virgili University, 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-5486","authenticated-orcid":false,"given":"Rafael","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Critical Care Department, Hospital Universitario Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-4063","authenticated-orcid":false,"given":"Ignacio","family":"Mart\u00edn-Loeches","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James\u2019 Hospital, D08 NHY1 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-2889","authenticated-orcid":false,"given":"Frederic F.","family":"G\u00f3mez-Bertomeu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Faculty of Medicine and Health Sciences, Rovira & Virgili University, 43005 Tarragona, Spain"},{"name":"Microbiology\/Clinical Analysis Laboratory, Hospital Universitari de Tarragona Joan XXIII, Mallafr\u00e9 Guasch 4, 43007 Tarragona, Spain"},{"name":"IISPV (Instituto de Investigaci\u00f3n Sanitaria Pere Virgili), 43005 Tarragona, Spain"},{"name":"Centre for Biomedical Research in Infectious Diseases Network (CIBERINFEC), 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-5984","authenticated-orcid":false,"given":"Alejandro","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Critical Care Department, Hospital Universitari de Tarragona Joan XXIII, Mallafr\u00e9 Guasch 4, 43007 Tarragona, Spain"},{"name":"IISPV (Instituto de Investigaci\u00f3n Sanitaria Pere Virgili), 43005 Tarragona, Spain"},{"name":"Centre for Biomedical Research Network Respiratory Diseases (CIBERES), 43005 Tarragona, Spain"},{"name":"Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Rovira & Virgili University, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s13054-023-04673-6","article-title":"Critical appraisal beyond clinical guidelines for intraabdominal candidiasis","volume":"27","author":"Maseda","year":"2023","journal-title":"Crit. 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