{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:02:24Z","timestamp":1788282144862,"version":"build-2803163510"},"reference-count":11,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico-CNPq"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-CAPES"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Cryptococcosis is a serious fungal infection mainly caused by two Cryptococcus species, Cryptococcus gattii and Cryptococcus neoformans species complexes. Even though it is considered a dangerous disease, this infection is also neglected worldwide and its research is not adequately funded. The molecular understanding of the infection, which could help in the development of specific treatments and appropriate management, is hampered, as molecular data are not of easy access. With that purpose, our group developed a Cryptococcus molecular database, grouping published molecular data on gene and protein differential expression that occurred due to the infection. CRYPTOMICSDB presents a user-friendly interface, and users can search for both pathogen or host information and visualize data on experimental approaches, animal models or cell culture, Cryptococcus species and strain, genes and proteins. The database features 19,462 and 986,507 total genes related to the pathogen and host views, respectively. CRYPTOMICSDB is a powerful tool that can help health workers and microbiology researchers to better understand the molecular impact caused by cryptococcosis infection process.<\/jats:p>","DOI":"10.3390\/jof11060425","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T10:21:49Z","timestamp":1748859709000},"page":"425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CRYPTOMICSDB: Revealing the Molecular Landscape of Cryptococcosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-5786","authenticated-orcid":false,"given":"Yohana Porto","family":"Calegari-Alves","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-4888","authenticated-orcid":false,"given":"Camila","family":"Innocente-Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Pereira","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-8580","authenticated-orcid":false,"given":"Aline Martins","family":"Faustino","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn Scheffler Schirma","family":"Farias","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-5241","authenticated-orcid":false,"given":"Mateus","family":"Boiani","sequence":"additional","affiliation":[{"name":"Institute of Informatics, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0865-3266","authenticated-orcid":false,"given":"Bruno Samuel Ardenghi","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Informatics, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-3480","authenticated-orcid":false,"given":"Marcio","family":"Dorn","sequence":"additional","affiliation":[{"name":"Institute of Informatics, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"},{"name":"Center of Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-7839","authenticated-orcid":false,"given":"Walter Orlando","family":"Beys-da-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"},{"name":"Center of Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-7006","authenticated-orcid":false,"given":"Luc\u00e9lia","family":"Santi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil"},{"name":"Center of Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/21501203.2023.2295409","article-title":"The Pathways and the Mechanisms by Which Cryptococcus Enters the Brain","volume":"15","author":"Zhou","year":"2024","journal-title":"Mycology"},{"key":"ref_2","unstructured":"Jani, A., Reigler, A.N., Leal, S.M., and McCarty, T.P. 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