{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:22:17Z","timestamp":1760059337411,"version":"build-2065373602"},"reference-count":74,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Writing with the perspective of a mentor, friend, and colleague, I am elated to contribute to this commemorative issue of the Journal of Fungi, which is dedicated to the landmark contributions of Dr. Dimitrios P. Kontoyiannis, who has greatly advanced our understanding of the epidemiology, pathogenesis, diagnosis, and treatment of mucormycosis. Through his efforts and leadership, the four pillars in the management of mucormycosis have been made much stronger: early diagnosis, the rapid initiation of antifungal therapy, augmentation of the host\u2019s defenses, and surgical intervention.<\/jats:p>","DOI":"10.3390\/jof11060435","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:08:31Z","timestamp":1749208111000},"page":"435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Commemorating the Landmark Advances in Our Understanding of Mucormycosis by Dimitrios P. Kontoyiannis"],"prefix":"10.3390","volume":"11","author":[{"given":"Thomas J.","family":"Walsh","sequence":"first","affiliation":[{"name":"Center for Innovative Therapeutics and Diagnostics, Richmond, VA 23220, USA"},{"name":"Departments of Medicine and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/cid\/cir866","article-title":"Epidemiology and clinical manifestations of mucormycosis","volume":"54","author":"Petrikkos","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1086\/313803","article-title":"Zygomycosis in the 1990s in a tertiary-care cancer center","volume":"30","author":"Kontoyiannis","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1086\/430710","article-title":"Cancer","volume":"41","author":"Chamilos","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/myc.12101","article-title":"Risk factors for early mortality in haematological malignancy patients with pulmonary mucormycosis","volume":"57","author":"Lewis","year":"2014","journal-title":"Mycoses"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3201\/eid1710.110087","article-title":"Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001\u20132006","volume":"17","author":"Park","year":"2011","journal-title":"Emerg. Infect Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kontoyiannis, D.P., Yang, H., Song, J., Kelkar, S.S., Yang, X., Azie, N., Harrington, R., Fan, A., Lee, E., and Spalding, J.R. (2016). Prevalence, clinical and economic burden of mucormycosis-related hospitalizations in the United States: A retrospective study. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-2023-z"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/CMR.00056-10","article-title":"Mucormycosis caused by unusual Mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species","volume":"24","author":"Gomes","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Gamaletsou, M.N., Rammaert, B., Brause, B., Bueno, M.A., Dadwal, S.S., Henry, M.W., Katragkou, A., Kontoyiannis, D.P., McCarthy, M.W., and Miller, A.O. (2022). Osteoarticular Mycoses. Clin. Microbiol. Rev., 35.","DOI":"10.1128\/cmr.00086-19"},{"key":"ref_9","first-page":"691","article-title":"Bone and joint infections caused by mucormycetes: A challenging osteoarticular mycosis of the twenty-first century","volume":"55","author":"Gamaletsou","year":"2017","journal-title":"Med. Mycol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"John, T.M., Jacob, C.N., and Kontoyiannis, D.P. (2021). When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis. J. Fungi, 7.","DOI":"10.3390\/jof7040298"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/myc.13578","article-title":"Multimodal analysis of the COVID-19-associated mucormycosis outbreak in Delhi, India indicates the convergence of clinical and environmental risk factors","volume":"66","author":"Chowdhary","year":"2023","journal-title":"Mycoses"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Skaria, J., John, T.M., Varkey, S., and Kontoyiannis, D.P. (2022). Are Unique Regional Factors the Missing Link in India\u2019s COVID-19-Associated Mucormycosis Crisis?. mBio, 13.","DOI":"10.1128\/mbio.00473-22"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1128\/AAC.00994-09","article-title":"Culture medium composition affects the lethality of Cunninghamella bertholletiae in a fly model of mucormycosis","volume":"53","author":"Pongas","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jinf.2009.06.002","article-title":"A clinicopathological study of pulmonary mucormycosis in cancer patients: Extensive angioinvasion but limited inflammatory response","volume":"59","author":"Luna","year":"2009","journal-title":"J. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/cid\/cir865","article-title":"Pathogenesis of mucormycosis","volume":"54","author":"Ibrahim","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1093\/cid\/cir869","article-title":"Host defenses against zygomycetes","volume":"54","author":"Roilides","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/13693786.2012.690107","article-title":"Increased virulence of Cunninghamella bertholletiae in experimental pulmonary mucormycosis: Correlation with circulating molecular biomarkers, sporangiospore germination and hyphal metabolism","volume":"51","author":"Petraitis","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1073\/pnas.0709578105","article-title":"Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis","volume":"105","author":"Chamilos","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1128\/AAC.01583-15","article-title":"Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae","volume":"59","author":"Bellanger","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/21505594.2015.1039762","article-title":"Glucocorticosteroids do not impact directly growth rate and biomass of Rhizopus arrhizus (syn. R. oryzae) in vitro","volume":"6","author":"Bellanger","year":"2015","journal-title":"Virulence"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/21505594.2015.1009732","article-title":"Iron starvation induces apoptosis in Rhizopus oryzae in vitro","volume":"6","author":"Shirazi","year":"2015","journal-title":"Virulence"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1172\/JCI82744","article-title":"Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis","volume":"126","author":"Gebremariam","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e00698-18","DOI":"10.1128\/AAC.00698-18","article-title":"Immunosuppressed Adult Zebrafish Model of Mucormycosis","volume":"62","author":"Tatara","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1038\/s41467-018-05820-2","article-title":"Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species","volume":"9","author":"Andrianaki","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1473-3099(06)70686-7","article-title":"Role of mini-host models in the study of medically important fungi","volume":"7","author":"Chamilos","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e01414-20","DOI":"10.1128\/mBio.01414-20","article-title":"Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds","volume":"11","author":"Wurster","year":"2020","journal-title":"mBio."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Walsh, T.J., Hospenthal, D.R., Petraitis, V., and Kontoyiannis, D.P. (2019). Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma. J. Fungi, 5.","DOI":"10.3390\/jof5030057"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/myc.13638","article-title":"Invasive mucorales sinusitis in a young patient with Emberger syndrome and newly diagnosed AML: A case report and literature review of invasive fungal infections in GATA2 deficiency","volume":"66","author":"Chiu","year":"2023","journal-title":"Mycoses"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Alqarihi, A., Kontoyiannis, D.P., and Ibrahim, A.S. (2023). Mucormycosis in 2023: An update on pathogenesis and management. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1254919"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/590004","article-title":"Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis","volume":"47","author":"Chamilos","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/13693780701639546","article-title":"The use of 18F-fluorodeoxyglucose positron emission tomography for the diagnosis and management of invasive mould infections","volume":"46","author":"Chamilos","year":"2008","journal-title":"Med. Mycol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1086\/587991","article-title":"Reversed halo sign in invasive pulmonary fungal infections","volume":"46","author":"Wahba","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/cid\/cir122","article-title":"The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts","volume":"52","author":"Georgiadou","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wurster, S., Cho, S.Y., Allos, H., Franklin, A., Axell-House, D.B., Jiang, Y., and Kontoyiannis, D.P. (2024). Concordance of Chest Radiography and Chest Computed Tomography Findings in Patients with Hematologic Malignancy and Invasive Mucormycosis: What Are the Prognostic Implications?. J. Fungi, 10.","DOI":"10.3390\/jof10100703"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1093\/cid\/cir868","article-title":"Early clinical and laboratory diagnosis of invasive pulmonary, extrapulmonary, and disseminated mucormycosis (zygomycosis)","volume":"54","author":"Walsh","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1128\/JCM.00917-08","article-title":"Detection of a molecular biomarker for zygomycetes by quantitative PCR assays of plasma, bronchoalveolar lavage, and lung tissue in a rabbit model of experimental pulmonary zygomycosis","volume":"46","author":"Kasai","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/14737159.2018.1522250","article-title":"Recent advances in the molecular diagnosis of mucormycosis","volume":"18","author":"Dadwal","year":"2018","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/myc.12249","article-title":"Development of new strategies for early diagnosis of mucormycosis from bench to bedside","volume":"57","author":"Walsh","year":"2014","journal-title":"Mycoses"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Stafylaki, D., Maraki, S., Vaporidi, K., Georgopoulos, D., Kontoyiannis, D.P., Kofteridis, D.P., and Chamilos, G. (2022). Impact of Molecular Syndromic Diagnosis of Severe Pneumonia in the Management of Critically Ill Patients. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.01616-22"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1093\/cid\/ciaa1836","article-title":"Molecular Techniques for Genus and Species Determination of Fungi from Fresh and Paraffin-Embedded Formalin-Fixed Tissue in the Revised EORTC\/MSGERC Definitions of Invasive Fungal Infection","volume":"72","author":"Lockhart","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1086\/590566","article-title":"Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria","volume":"47","author":"Segal","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1182\/blood-2011-03-316430","article-title":"How I treat mucormycosis","volume":"118","author":"Kontoyiannis","year":"2011","journal-title":"Blood"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1086\/599105","article-title":"Recent advances in the management of mucormycosis: From bench to bedside","volume":"48","author":"Goldstein","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/cid\/cir862","article-title":"Meeting the challenges of an emerging pathogen: The Henry Schueler 41&9 Foundation International Forum on Mucormycosis","volume":"54","author":"Walsh","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1093\/cid\/cir884","article-title":"How does antifungal pharmacology differ for mucormycosis versus aspergillosis?","volume":"54","author":"Lewis","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/AAC.01222-09","article-title":"Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of pulmonary mucormycosis","volume":"54","author":"Lewis","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/AAC.01812-10","article-title":"Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis","volume":"55","author":"Lewis","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1128\/AAC.50.2.658-666.2006","article-title":"Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis","volume":"50","author":"Ullmann","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lewis, R.E., Wurster, S., Beyda, N.D., Albert, N.D., and Kontoyiannis, D.P. (2019). Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis. Diagn. Microbiol. Infect. Dis., 95.","DOI":"10.1016\/j.diagmicrobio.2019.06.013"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1128\/AAC.03569-14","article-title":"Comparative pharmacodynamics of posaconazole in neutropenic murine models of invasive pulmonary aspergillosis and mucormycosis","volume":"58","author":"Lewis","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/infdis\/jis767","article-title":"Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis","volume":"207","author":"Lewis","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1128\/AAC.00571-13","article-title":"Hyperthermia sensitizes Rhizopus oryzae to posaconazole and itraconazole action through apoptosis","volume":"57","author":"Shirazi","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Shirazi, F., and Kontoyiannis, D.P. (2013). Mitochondrial respiratory pathways inhibition in Rhizopus oryzae potentiates activity of posaconazole and itraconazole via apoptosis. PLoS ONE., 8.","DOI":"10.1371\/journal.pone.0063393"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/AAC.00792-10","article-title":"Activity of deferasirox in Mucorales: Influences of species and exogenous iron","volume":"55","author":"Lewis","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Barbu, E.M., Shirazi, F., McGrath, D.M., Albert, N., Sidman, R.L., Pasqualini, R., Arap, W., and Kontoyiannis, D.P. (2013). An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076981"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/infdis\/jiw090","article-title":"Statin Concentrations Below the Minimum Inhibitory Concentration Attenuate the Virulence of Rhizopus oryzae","volume":"214","author":"Bellanger","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1469-0691.2005.01170.x","article-title":"Hyperbaric oxygen as an adjunctive treatment for zygomycosis","volume":"11","author":"John","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/AAC.00956-09","article-title":"Antifungal activity of colistin against mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection","volume":"54","author":"Lewis","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1469-0691.2009.02988.x","article-title":"Voriconazole-associated zygomycosis: A significant consequence of evolving antifungal prophylaxis and immunosuppression practices?","volume":"15","author":"Pongas","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4161\/viru.2.4.17074","article-title":"Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection","volume":"2","author":"Lewis","year":"2011","journal-title":"Virulence"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.bmt.1705614","article-title":"Breakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapy","volume":"39","author":"Trifilio","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/cid\/ciy406","article-title":"Breakthrough Fungal Infections in Patients with Leukemia Receiving Isavuconazole","volume":"67","author":"Rausch","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Axell-House, D.B., Wurster, S., Jiang, Y., Kyvernitakis, A., Lewis, R.E., Tarrand, J.J., Raad, I.I., and Kontoyiannis, D.P. (2021). Breakthrough Mucormycosis Developing on Mucorales-Active Antifungals Portrays a Poor Prognosis in Patients with Hematologic Cancer. J. Fungi, 7.","DOI":"10.3390\/jof7030217"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1093\/cid\/cir885","article-title":"Combination therapy for mucormycosis: Why, what, and how?","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"811.e1","DOI":"10.1016\/j.cmi.2016.03.029","article-title":"Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: A propensity score analysis","volume":"22","author":"Kyvernitakis","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jtct.2025.01.892","article-title":"American Society of Transplantation and Cellular Therapy Series: #8-Management and Prevention of Non-Aspergillus Molds in Hematopoietic Cell Transplantation Recipients","volume":"31","author":"Douglas","year":"2025","journal-title":"Transplant. Cell Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1093\/infdis\/jiaa394","article-title":"Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium","volume":"222","author":"Johnson","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/cid\/ciz1195","article-title":"How Long Do We Need to Treat an Invasive Mold Disease in Hematology Patients? Factors Influencing Duration of Therapy and Future Questions","volume":"71","author":"Lewis","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S474","DOI":"10.1093\/infdis\/jix130","article-title":"Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi","volume":"216","author":"McCarthy","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Wurster, S., Albert, N.D., Bharadwaj, U., Kasembeli, M.M., Tarrand, J.J., Daver, N., and Kontoyiannis, D.P. (2022). Blockade of the PD-1\/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.838344"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wurster, S., Watowich, S.S., and Kontoyiannis, D.P. (2022). Checkpoint inhibitors as immunotherapy for fungal infections: Promises, challenges, and unanswered questions. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1018202"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.omtm.2018.03.003","article-title":"A New Method for Reactivating and Expanding T Cells Specific for Rhizopus oryzae","volume":"9","author":"Castillo","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2666-5247(24)00039-9","article-title":"Impact of climate change and natural disasters on fungal infections","volume":"5","author":"Seidel","year":"2024","journal-title":"Lancet Microbe"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/6\/435\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:47:57Z","timestamp":1760032077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/11\/6\/435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":74,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jof11060435"],"URL":"https:\/\/doi.org\/10.3390\/jof11060435","relation":{},"ISSN":["2309-608X"],"issn-type":[{"type":"electronic","value":"2309-608X"}],"subject":[],"published":{"date-parts":[[2025,6,6]]}}}